Research workbench
Approach for targeting RAS with small molecules that activate sos- mediated nucleotide exchange
Analyse Approach for targeting RAS with small molecules that activate sos- mediated… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4NYJ
- Type
- protein
- Length
- 800 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GTPase HRAS; Son of sevenless homolog 1
- UniProt
- P01112, Q07889
- Ligands
- GNP, 2PZ, MG
- Pockets
- 12 · best druggability 0.78
Structure
x-ray diffraction · 3 distinct chains · 48% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| Q | GTPase HRAS | protein | 166 | 36% helix, 27% strand | P01112 |
| R | GTPase HRAS | protein | 166 | 34% helix, 25% strand | P01112 |
| S | Son of sevenless homolog 1 | protein | 468 | 57% helix, 4% strand | Q07889 |
Ligands and binding sites
- GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · chains Q
- 2PZ · N-[1-(1H-indol-3-ylmethyl)piperidin-4-yl]glycinamide · ligand · chains S
- MG · Magnesium ion · metal · chains Q
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 987 | 0.78 | 0.80 | 90 | MG, GNP |
| 2 | 329 | 0.70 | 0.83 | 47 | empty |
| 3 | 60 | 0.65 | 0.94 | 16 | empty |
| 4 | 316 | 0.63 | 0.79 | 46 | empty |
| 5 | 276 | 0.54 | 0.76 | 36 | empty |
Interfaces
2 interfaces between chains.
- R–S · 1806 Ų buried · 24 hydrogen bonds · protein-protein
- Q–S · 1550 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 4NYJ · Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide… · the same entry in another collection · chain Q against Q, TM-score 1.00
- P01112 · AlphaFold monomer V2.0 prediction for GTPase HRAS (P01112) · a predicted model of the same protein · chain Q against A, TM-score 0.99
- Q07889 · AlphaFold monomer V2.0 prediction for son of sevenless homolog 1 (Q07889) · a predicted model of the same protein · chain S against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01112
- Every structure of UniProt Q07889
- Elsewhere: RCSB PDB 4NYJ · PDBe 4NYJ · UniProt P01112 · UniProt Q07889
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.