UniProt P01112
GTPase HRAS (P01112)
GTPase HRAS (UniProt P01112), EC 3.6.5.2: 395 experimental structures on GenesisL1, 18 ligands bound, 261 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P01112
- Protein
- GTPase HRAS
- EC
- 3.6.5.2
- Experimental structures
- 395
- Predicted models
- 0
- Ligands
- 18
- Pockets
- 261 · 48 records with a druggable one
Structures
395 records of P01112 in the MolNFT archive: 395 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 121P | Struktur und guanosintriphosphat-hydrolysemechanismus des C-terminal verkuerzten menschlichen… | x-ray diffraction | A | — | — |
| 121P | Struktur und guanosintriphosphat-hydrolysemechanismus des C-terminal verkuerzten menschlichen… | x-ray diffraction | A | — | — |
| 1AA9 | Human C-ha-RAS(1-171)(DOT)GDP, NMR, minimized average structure | solution nmr | A | — | — |
| 1AA9 | Human C-ha-RAS(1-171)(DOT)GDP, NMR, minimized average structure | solution nmr | A | — | — |
| 1AGP | Three-dimensional structures and properties of a transforming and a nontransforming gly-12 mutant… | x-ray diffraction | A | — | — |
| 1AGP | Three-dimensional structures and properties of a transforming and a nontransforming gly-12 mutant… | x-ray diffraction | A | — | — |
| 1BKD | Complex of human H-RAS with human sos-1 | x-ray diffraction | R | — | — |
| 1BKD | Complex of human H-RAS with human sos-1 | x-ray diffraction | R | — | — |
| 1CLU | H-RAS complexed with diaminobenzophenone-BETA,GAMMA-imido-GTP | x-ray diffraction | A | — | — |
| 1CLU | H-RAS complexed with diaminobenzophenone-BETA,GAMMA-imido-GTP | x-ray diffraction | A | — | — |
| 1CRP | The solution structure and dynamics of RAS P21. GDP determined by heteronuclear three and four… | solution nmr | A | — | — |
| 1CRP | The solution structure and dynamics of RAS P21. GDP determined by heteronuclear three and four… | solution nmr | A | — | — |
| 1CRQ | The solution structure and dynamics of RAS P21. GDP determined by heteronuclear three and four… | solution nmr | A | — | — |
| 1CRQ | The solution structure and dynamics of RAS P21. GDP determined by heteronuclear three and four… | solution nmr | A | — | — |
| 1CRR | The solution structure and dynamics of RAS P21. GDP determined by heteronuclear three and four… | solution nmr | A | — | — |
| 1CRR | The solution structure and dynamics of RAS P21. GDP determined by heteronuclear three and four… | solution nmr | A | — | — |
| 1CTQ | Structure of P21RAS in complex with gppnhp at 100 K | x-ray diffraction | A | — | — |
| 1CTQ | Structure of P21RAS in complex with gppnhp at 100 K | x-ray diffraction | A | — | — |
| 1GNP | X-ray crystal structure analysis of the catalytic domain of the oncogene product P21H-RAS complexed… | x-ray diffraction | A | — | — |
| 1GNP | X-ray crystal structure analysis of the catalytic domain of the oncogene product P21H-RAS complexed… | x-ray diffraction | A | — | — |
| 1GNQ | X-ray crystal structure analysis of the catalytic domain of the oncogene product P21H-RAS complexed… | x-ray diffraction | A | — | — |
| 1GNQ | X-ray crystal structure analysis of the catalytic domain of the oncogene product P21H-RAS complexed… | x-ray diffraction | A | — | — |
| 1GNR | X-ray crystal structure analysis of the catalytic domain of the oncogene product P21H-RAS complexed… | x-ray diffraction | A | — | — |
| 1GNR | X-ray crystal structure analysis of the catalytic domain of the oncogene product P21H-RAS complexed… | x-ray diffraction | A | — | — |
| 1IAQ | C-H-RAS P21 protein mutant with thr 35 replaced by ser (T35S) complexed with… | x-ray diffraction | A, B, C | — | — |
| 1IAQ | C-H-RAS P21 protein mutant with thr 35 replaced by ser (T35S) complexed with… | x-ray diffraction | A, B, C | — | — |
| 1IOZ | Crystal Structure of the C-HA-RAS Protein Prepared by the Cell-Free Synthesis | x-ray diffraction | A | — | — |
| 1IOZ | Crystal structure of the C-ha-RAS protein prepared by the cell-free synthesis | x-ray diffraction | A | — | — |
| 1JAH | H-RAS P21 protein mutant G12P, complexed with guanosine-5'-[BETA,GAMMA-methylene] triphosphate and… | x-ray diffraction | A | — | — |
| 1JAH | H-RAS P21 protein mutant G12P, complexed with guanosine-5'-[beta, gamma-methylene] triphosphate and… | x-ray diffraction | A | — | — |
| 1JAI | H-RAS P21 protein mutant G12P, complexed with guanosine-5'-[BETA,GAMMA-methylene] triphosphate and… | x-ray diffraction | A | — | — |
| 1JAI | H-RAS P21 protein mutant G12P, complexed with guanosine-5'-[beta, gamma-methylene] triphosphate and… | x-ray diffraction | A | — | — |
| 1K8R | Crystal structure of Ras-Bry2RBD complex | x-ray diffraction | A | — | — |
| 1K8R | Crystal structure of RAS-BRY2RBD complex | x-ray diffraction | A | — | — |
| 1LF0 | Crystal Structure of RasA59G in the GTP-bound form | x-ray diffraction | A | — | — |
| 1LF0 | Crystal structure of RASA59G in the GTP-bound form | x-ray diffraction | A | — | — |
| 1LF5 | Crystal Structure of RasA59G in the GDP-bound Form | x-ray diffraction | A | — | — |
| 1LF5 | Crystal structure of RASA59G in the GDP-bound form | x-ray diffraction | A | — | — |
| 1LFD | Crystal structure of the active RAS protein complexed with the RAS-interacting domain of ralgds | x-ray diffraction | B, D | — | — |
| 1LFD | Crystal structure of the active RAS protein complexed with the RAS- interacting domain of ralgds | x-ray diffraction | B, D | — | — |
| 1NVU | Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange… | x-ray diffraction | Q, R | — | — |
| 1NVU | Structural evidence for feedback activation by rasgtp of the RAS- specific nucleotide exchange… | x-ray diffraction | Q, R | — | — |
| 1NVV | Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange… | x-ray diffraction | Q, R | — | — |
| 1NVV | Structural evidence for feedback activation by rasgtp of the RAS- specific nucleotide exchange… | x-ray diffraction | Q, R | — | — |
| 1NVW | Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange… | x-ray diffraction | Q, R | — | — |
| 1NVW | Structural evidence for feedback activation by rasgtp of the RAS-specific nucleotide exchange… | x-ray diffraction | Q, R | — | — |
| 1NVX | Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange… | x-ray diffraction | Q, R | — | — |
| 1NVX | Structural evidence for feedback activation by rasgtp of the RAS- specific nucleotide exchange… | x-ray diffraction | Q, R | — | — |
| 1P2S | H-Ras 166 in 50% 2,2,2 triflouroethanol | x-ray diffraction | A | — | — |
| 1P2S | H-RAS 166 in 50% 2,2,2 triflouroethanol | x-ray diffraction | A | — | — |
| 1P2T | H-Ras 166 in Aqueous mother liqour, RT | x-ray diffraction | A | — | — |
| 1P2T | H-RAS 166 in aqueous mother liqour, rt | x-ray diffraction | A | — | — |
| 1P2U | H-Ras in 50% isopropanol | x-ray diffraction | A | — | — |
| 1P2U | H-RAS in 50% isopropanol | x-ray diffraction | A | — | — |
| 1P2V | H-RAS 166 in 60 % 1,6 hexanediol | x-ray diffraction | A | — | — |
| 1P2V | H-RAS 166 in 60 % 1,6 hexanediol | x-ray diffraction | A | — | — |
| 1PLJ | Crystallographic studies on P21H-RAS using synchrotron laue method: improvement of crystal quality… | x-ray diffraction | A | — | — |
| 1PLJ | Crystallographic studies on P21H-RAS using synchrotron laue method: improvement of crystal quality… | x-ray diffraction | A | — | — |
| 1PLK | Crystallographic studies on P21H-RAS using synchrotron laue method: improvement of crystal quality… | x-ray diffraction | A | — | — |
| 1PLK | Crystallographic studies on P21H-RAS using synchrotron laue method: improvement of crystal quality… | x-ray diffraction | A | — | — |
335 records more on the page itself.
Ligands
- MG · Magnesium ion · in 131 records
- GNP · Phosphoaminophosphonic acid-guanylate ester · in 111 records
- NA · Sodium ion · in 43 records
- CA · Calcium ion · in 26 records
- GDP · Guanosine-5'-diphosphate · in 15 records
- 92V · 1-(4-methoxyphenyl)-N-(3-sulfanylpropyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide · in 4 records
- CL · Chloride ion · in 4 records
- GSP · 5'-guanosine-diphosphate-monothiophosphate · in 4 records
- EZZ · (3~{S})-3-[2-[(dimethylamino)methyl]-1~{H}-indol-3-yl]-5-oxidanyl-2,3-dihydroisoindol-1-one · in 3 records
- GCP · Phosphomethylphosphonic acid guanylate ester · in 3 records
- BEF · Beryllium trifluoride ion · in 2 records
- QTA · 3-(phenylsulfonyl)benzene-1-sulfonamide · in 2 records
- SO4 · Sulfate ion · in 2 records
- KBF · 3-oxidanyl-~{N}-[[(2~{R})-oxolan-2-yl]methyl]naphthalene-2-carboxamide · in 1 record
- MGF · Trifluoromagnesate · in 1 record
- YCN · 1,4,7,10-tetraazacyclododecane · in 1 record
- ZN · Zinc ion · in 1 record
- ZNI · (1R,5S,6r)-N-[(1P,7S,9S,13S,20M)-20-{5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl}-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide · in 1 record
Elsewhere
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