Crystal structure of Human Complement Factor H, SCR domains 6-8 (H402 risk variant), in complex with ligand.

Structure

x-ray diffraction · resolution 2.35 · 1 distinct chain · 4% helix, 39% strand (DSSP).

Ligands and binding sites

• GU4 · 2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose · sugar · chains A
• YYJ · 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose · sugar · chains A
• SO4 · Sulfate ion · ion · 3 copies · chains A
• CL · Chloride ion · ion · 2 copies · chains A
• ACT · Acetate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

• 2UWN · Crystal structure of human complement factor H, scr domains 6-8 (H402 risk variant), in… · the same entry in another collection · chain A against A, TM-score 1.00
• P08603 · AlphaFold monomer V2.0 prediction for complement factor H (P08603) · a predicted model of the same protein · chain A against A, TM-score 0.50

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P08603
• Elsewhere: RCSB PDB 2UWN · PDBe 2UWN · UniProt P08603