UniProt P08603
Complement factor H (P08603)
Complement factor H (UniProt P08603): 80 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 2 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P08603
- Protein
- Complement factor H
- Experimental structures
- 80
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 2 · 0 records with a druggable one
Structures
81 records of P08603 in the MolNFT archive: 80 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1HAQ | Four models of human factor H determined by solution scattering curve-fitting and homology modelling | solution scattering | A | — | — |
| 1HAQ | Four models of human factor H determined by solution scattering curve-fitting and homology modelling | solution scattering | A | — | — |
| 1HCC | Three-dimensional structure of a complement control protein module in solution | solution nmr | A | — | — |
| 1HCC | Three-dimensional structure of a complement control protein module in solution | solution nmr | A | — | — |
| 1HFH | Solution structure of a pair of complement modules by nuclear magnetic resonance | solution nmr | A | — | — |
| 1HFH | Solution structure of a pair of complement modules by nuclear magnetic resonance | solution nmr | A | — | — |
| 1HFI | Solution structure of a pair of complement modules by nuclear magnetic resonance | solution nmr | A | — | — |
| 1HFI | Solution structure of a pair of complement modules by nuclear magnetic resonance | solution nmr | A | — | — |
| 2BZM | Solution structure of the primary host recognition region of complement factor H | solution nmr | A | — | — |
| 2BZM | Solution structure of the primary host recognition region of complement factor H | solution nmr | A | — | — |
| 2G7I | Structure of Human Complement Factor H Carboxyl Terminal Domains 19-20: a Basis for Atypical… | x-ray diffraction | A | — | — |
| 2G7I | Structure of human complement factor H carboxyl terminal domains 19- 20: a basis for atypical… | x-ray diffraction | A | — | — |
| 2IC4 | Solution structure of the His402 allotype of the Factor H SCR6-SCR7-SCR8 fragment | solution scattering | A | — | — |
| 2IC4 | Solution structure of the HIS402 allotype of the factor H SCR6-SCR7- SCR8 fragment | solution scattering | A | — | — |
| 2JGW | Structure of CCP module 7 of complement factor H - The AMD at risk varient (402H) | solution nmr | A | — | — |
| 2JGW | Structure of ccp module 7 of complement factor H - the amd at risk varient (402H) | solution nmr | A | — | — |
| 2JGX | Structure of CCP module 7 of complement factor H - The AMD Not at risk varient (402Y) | solution nmr | A | — | — |
| 2JGX | Structure of ccp module 7 of complement factor H - the amd not at risk varient (402Y) | solution nmr | A | — | — |
| 2KMS | Combined high- and low-resolution techniques reveal compact structure in central portion of factor… | solution nmr | A | — | — |
| 2KMS | Combined high- and low-resolution techniques reveal compact structure in central portion of factor… | solution nmr | A | — | — |
| 2QFG | Solution Structure of the N-terminal SCR-1/5 fragment of Complement Factor H. | solution scattering | A | — | — |
| 2QFG | Solution structure of the N-terminal scr-1/5 fragment of complement factor H. | solution scattering | A | — | — |
| 2QFH | Solution Structure of the C-terminal SCR-16/20 fragment of Complement Factor H. | solution scattering | A | — | — |
| 2QFH | Solution structure of the C-terminal scr-16/20 fragment of complement factor H. | solution scattering | A | — | — |
| 2RLP | NMR structure of CCP modules 1-2 of complement factor H | solution nmr | A | — | — |
| 2RLP | NMR structure of ccp modules 1-2 of complement factor H | solution nmr | A | — | — |
| 2RLQ | NMR structure of CCP modules 2-3 of complement factor H | solution nmr | A | — | — |
| 2RLQ | NMR structure of ccp modules 2-3 of complement factor H | solution nmr | A | — | — |
| 2UWN | Crystal structure of Human Complement Factor H, SCR domains 6-8 (H402 risk variant), in complex… | x-ray diffraction | A | — | — |
| 2UWN | Crystal structure of human complement factor H, scr domains 6-8 (H402 risk variant), in complex… | x-ray diffraction | A | — | — |
| 2V8E | Crystal structure of Human Complement Factor H, SCR domains 6-8 (H402 risk variant), in complex… | x-ray diffraction | A | — | — |
| 2V8E | Crystal structure of human complement factor H, scr domains 6-8 (H402 risk variant), in complex… | x-ray diffraction | A | — | — |
| 2W80 | Structure of a complex between Neisseria meningitidis factor H binding protein and CCPs 6-7 of… | x-ray diffraction | A, B, E, G | — | — |
| 2W80 | Structure of a complex between neisseria meningitidis factor H binding protein and ccps 6-7 of… | x-ray diffraction | A, B, E, G | — | — |
| 2W81 | Structure of a complex between Neisseria meningitidis factor H binding protein and CCPs 6-7 of… | x-ray diffraction | A, B, E | — | — |
| 2W81 | Structure of a complex between neisseria meningitidis factor H binding protein and ccps 6-7 of… | x-ray diffraction | A, B, E | — | — |
| 2WII | Complement C3b in complex with factor H domains 1-4 | x-ray diffraction | C | — | — |
| 2WII | Complement C3B in complex with factor H domains 1-4 | x-ray diffraction | C | — | — |
| 2XQW | Structure of Factor H domains 19-20 in complex with complement C3d | x-ray diffraction | C | — | — |
| 2XQW | Structure of factor H domains 19-20 in complex with complement C3D | x-ray diffraction | C | — | — |
| 3GAU | Solution structure of Human Complement Factor H in 50 mM NaCl buffer | solution scattering | A | — | — |
| 3GAU | Solution structure of human complement factor H in 50 mm nacl buffer | solution scattering | A | — | — |
| 3GAV | Solution structure of Human Complement Factor H in 137 mM NaCl buffer | solution scattering | A | — | — |
| 3GAV | Solution structure of human complement factor H in 137 mm nacl buffer | solution scattering | A | — | — |
| 3GAW | Solution structure of Human Complement Factor H in 250 mM NaCl buffer | solution scattering | A | — | — |
| 3GAW | Solution structure of human complement factor H in 250 mm nacl buffer | solution scattering | A | — | — |
| 3KXV | Structure of complement Factor H variant Q1139A | x-ray diffraction | A | — | — |
| 3KXV | Structure of complement factor H variant Q1139A | x-ray diffraction | A | — | — |
| 3KZJ | Structure of complement Factor H variant R1203A | x-ray diffraction | A | — | — |
| 3KZJ | Structure of complement factor H variant R1203A | x-ray diffraction | A | — | — |
| 3R62 | Structure of complement regulator Factor H mutant, T1184R. | x-ray diffraction | A, B | — | — |
| 3R62 | Structure of complement regulator factor H mutant, T1184R. | x-ray diffraction | A, B | — | — |
| 3SW0 | Structure of the C-terminal region (modules 18-20) of complement regulator Factor H | x-ray diffraction | X | — | — |
| 3SW0 | Structure of the C-terminal region (modules 18-20) of complement regulator factor H | x-ray diffraction | X | — | — |
| 4AYD | Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis… | x-ray diffraction | A, B, E | — | — |
| 4AYD | Structure of a complex between ccps 6 and 7 of human complement factor H and neisseria meningitidis… | x-ray diffraction | A, B, E | — | — |
| 4AYE | Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis… | x-ray diffraction | A, B, E | — | — |
| 4AYE | Structure of a complex between ccps 6 and 7 of human complement factor H and neisseria meningitidis… | x-ray diffraction | A, B, E | — | — |
| 4AYI | Structure of a complex between CCPs 6 and 7 of Human Complement Factor H and Neisseria meningitidis… | x-ray diffraction | A, E | — | — |
| 4AYI | Structure of a complex between ccps 6 and 7 of human complement factor H and neisseria meningitidis… | x-ray diffraction | A, E | — | — |
21 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 4ZH1 chain E against the predicted model P08603: TM-score 0.94, RMSD 1.11 Å
- 4ZH1 chain E against the predicted model P08603: TM-score 0.94, RMSD 1.11 Å
- 4J38 chain B against the predicted model P08603: TM-score 0.93, RMSD 1.35 Å
- 4J38 chain B against the predicted model P08603: TM-score 0.93, RMSD 1.35 Å
- 4ONT chain E against the predicted model P08603: TM-score 0.92, RMSD 1.41 Å
- 4ONT chain E against the predicted model P08603: TM-score 0.92, RMSD 1.41 Å
- 2G7I chain A against the predicted model P08603: TM-score 0.92, RMSD 1.33 Å
- 2G7I chain A against the predicted model P08603: TM-score 0.92, RMSD 1.33 Å
- 4ZH1 chain F against the predicted model P08603: TM-score 0.91, RMSD 1.46 Å
- 4ZH1 chain F against the predicted model P08603: TM-score 0.91, RMSD 1.46 Å
Elsewhere
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