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Human vascular endothelial growth factor receptor 2 (kdr) kinase domain

Analyse Human vascular endothelial growth factor receptor 2 (kdr) kinase domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1VR2
Type: protein
Length: 275 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.4
Source: Homo sapiens
Molecule: Protein (vascular endothelial growth factor receptor kinase)
EC: 2.7.1.112
UniProt: P35968
Pockets: 1 · best druggability 0.52

Structure

x-ray diffraction · resolution 2.4 · 1 distinct chain · 41% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein (vascular endothelial growth factor receptor kinase) (EC 2.7.1.112)	protein	275	41% helix, 17% strand	P35968

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	239	0.52	0.75	30	empty

Compared structures

1VR2 · Human vascular endothelial growth factor receptor 2 (kdr) kinase domain · the same entry in another collection · chain A against A, TM-score 1.00
P35968 · AlphaFold monomer V2.0 prediction for vascular endothelial growth factor receptor 2… · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P35968
Elsewhere: RCSB PDB 1VR2 · PDBe 1VR2 · UniProt P35968

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