MolNFT v1 · #496216 · protein
AlphaFold monomer V2.0 prediction for vascular endothelial growth factor receptor 2 (P35968)
P35968: “AlphaFold monomer V2.0 prediction for vascular endothelial growth factor receptor 2 (P35968)”. 10 pockets (best druggability 0.78). MolNFT v1 #496216 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P35968
- Type
- protein
- Length
- 1,356 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x463Be372c11f96eeBDBC4baa0AB3805D50aD7Ccd
- Molecule
- Vascular endothelial growth factor receptor 2
- UniProt
- P35968
- Pockets
- 10 · best druggability 0.78
Structure
1 distinct chain · 15% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Vascular endothelial growth factor receptor 2 | protein | 1356 | 15% helix, 33% strand | P35968 |
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1163 | 0.78 | 0.80 | 97 | empty |
| 2 | 626 | 0.68 | 0.77 | 68 | empty |
| 3 | 353 | 0.56 | 0.75 | 31 | empty |
| 4 | 315 | 0.53 | 0.74 | 38 | empty |
| 5 | 189 | 0.51 | 0.77 | 23 | empty |
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
- 6GQO · Crystal structure of human KDR (VEGFR2) kinase domain in complex with AZD3229-analogue… · an experimental structure of the same protein · chain A against A, TM-score 0.22
- 3U6J · Crystal structure of the VEGFR2 kinase domain in complex with a pyrazolone inhibitor · an experimental structure of the same protein · chain A against A, TM-score 0.22
- 6GQQ · Crystal structure of human KDR (VEGFR2) kinase domain in complex with AZD3229-analogue… · an experimental structure of the same protein · chain A against A, TM-score 0.22
- 6XVJ · Crystal structure of the KDR (VEGFR2) kinase domain in complex with a type-II inhibitor · an experimental structure of the same protein · chain A against A, TM-score 0.22
- 4AGC · CRYSTAL STRUCTURE OF VEGFR2 (JUXTAMEMBRANE AND KINASE DOMAINS) IN COMPLEX WITH AXITINIB… · an experimental structure of the same protein · chain A against A, TM-score 0.22
- 4ASD · Crystal Structure of VEGFR2 (Juxtamembrane and Kinase Domains) in Complex with SORAFENIB… · an experimental structure of the same protein · chain A against A, TM-score 0.22
- 4ASE · Crystal structure of VEGFR2 (juxtamembrane and kinase domains) in complex with tivozanib… · an experimental structure of the same protein · chain A against A, TM-score 0.22
- 4AGD · CRYSTAL STRUCTURE OF VEGFR2 (JUXTAMEMBRANE AND KINASE DOMAINS) IN COMPLEX WITH SUNITINIB… · an experimental structure of the same protein · chain A against A, TM-score 0.22
- 3VO3 · Crystal Structure of the Kinase domain of Human VEGFR2 with imidazo[1,2-b]pyridazine… · an experimental structure of the same protein · chain A against A, TM-score 0.22
- 3VHE · Crystal structure of human VEGFR2 kinase domain with a novel pyrrolopyrimidine inhibitor. · an experimental structure of the same protein · chain A against A, TM-score 0.22
- 3VNT · Crystal Structure of the Kinase domain of Human VEGFR2 with a… · an experimental structure of the same protein · chain A against A, TM-score 0.22
- 6XVK · Crystal structure of the KDR (VEGFR2) kinase domain in complex with a type-II inhibitor… · an experimental structure of the same protein · chain A against A, TM-score 0.22
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35968
- Elsewhere: UniProt P35968 · AlphaFold DB P35968
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