UniProt P35968
Vascular endothelial growth factor receptor 2 (P35968)
Vascular endothelial growth factor receptor 2 (UniProt P35968): 104 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 10 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P35968
- Protein
- Vascular endothelial growth factor receptor 2
- Experimental structures
- 104
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 10 · 1 record with a druggable one
Structures
105 records of P35968 in the MolNFT archive: 104 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1VR2 | Human vascular endothelial growth factor receptor 2 (kdr) kinase domain | x-ray diffraction | A | — | — |
| 1VR2 | Human vascular endothelial growth factor receptor 2 (kdr) kinase domain | x-ray diffraction | A | — | — |
| 1Y6A | Crystal structure of VEGFR2 in complex with a 2-anilino-5-aryl-oxazole inhibitor | x-ray diffraction | A | — | — |
| 1Y6A | Crystal structure of VEGFR2 in complex with a 2-anilino-5-aryl-oxazole inhibitor | x-ray diffraction | A | — | — |
| 1Y6B | Crystal structure of VEGFR2 in complex with a 2-anilino-5-aryl-oxazole inhibitor | x-ray diffraction | A | — | — |
| 1Y6B | Crystal structure of VEGFR2 in complex with a 2-anilino-5-aryl-oxazole inhibitor | x-ray diffraction | A | — | — |
| 1YWN | Vegfr2 in complex with a novel 4-amino-furo[2,3-d]pyrimidine | x-ray diffraction | A | — | — |
| 1YWN | VEGFR2 in complex with a novel 4-amino-FURO[2,3-D]PYRIMIDINE | x-ray diffraction | A | — | — |
| 2M59 | Spatial structure of dimeric VEGFR2 membrane domain in DPC micelles | solution nmr | A, B | — | — |
| 2M59 | Spatial structure of dimeric VEGFR2 membrane domain in dpc micelles | solution nmr | A, B | — | — |
| 2MET | NMR spatial structure of the trimeric mutant TM domain of VEGFR2 receptor. | solution nmr | A, B, C | — | — |
| 2MET | NMR spatial structure of the trimeric mutant tm domain of VEGFR2 receptor. | solution nmr | A, B, C | — | — |
| 2MEU | NMR spatial structure of mutant dimeric TM domain of VEGFR2 receptor | solution nmr | A, B | — | — |
| 2MEU | NMR spatial structure of mutant dimeric tm domain of VEGFR2 receptor | solution nmr | A, B | — | — |
| 2OH4 | Crystal structure of Vegfr2 with a benzimidazole-urea inhibitor | x-ray diffraction | A | — | — |
| 2OH4 | Crystal structure of VEGFR2 with a benzimidazole-urea inhibitor | x-ray diffraction | A | — | — |
| 2P2H | Crystal structure of the VEGFR2 kinase domain in complex with a pyridinyl-triazine inhibitor | x-ray diffraction | A | — | — |
| 2P2H | Crystal structure of the VEGFR2 kinase domain in complex with a pyridinyl-triazine inhibitor | x-ray diffraction | A | — | — |
| 2P2I | Crystal structure of the VEGFR2 kinase domain in complex with a nicotinamide inhibitor | x-ray diffraction | A, B | — | — |
| 2P2I | Crystal structure of the VEGFR2 kinase domain in complex with a nicotinamide inhibitor | x-ray diffraction | A, B | — | — |
| 2QU5 | Crystal structure of the VEGFR2 kinase domain in complex with a benzimidazole inhibitor | x-ray diffraction | A | — | — |
| 2QU5 | Crystal structure of the VEGFR2 kinase domain in complex with a benzimidazole inhibitor | x-ray diffraction | A | — | — |
| 2QU6 | Crystal structure of the VEGFR2 kinase domain in complex with a benzoxazole inhibitor | x-ray diffraction | A, B | — | — |
| 2QU6 | Crystal structure of the VEGFR2 kinase domain in complex with a benzoxazole inhibitor | x-ray diffraction | A, B | — | — |
| 2RL5 | Crystal structure of the VEGFR2 kinase domain in complex with a 2,3-dihydro-1,4-benzoxazine… | x-ray diffraction | A | — | — |
| 2RL5 | Crystal structure of the VEGFR2 kinase domain in complex with a 2,3- dihydro-1,4-benzoxazine… | x-ray diffraction | A | — | — |
| 2X1W | Crystal Structure of VEGF-C in Complex with Domains 2 and 3 of VEGFR2 | x-ray diffraction | L, M, N, O | — | — |
| 2X1W | Crystal structure of VEGF-C in complex with domains 2 and 3 of VEGFR2 | x-ray diffraction | L, M, N, O | — | — |
| 2X1X | Crystal structure of VEGF-C in complex with domains 2 and 3 of VEGFR2 in a tetragonal crystal form | x-ray diffraction | R | — | — |
| 2X1X | Crystal structure of VEGF-C in complex with domains 2 and 3 of VEGFR2 in a tetragonal crystal form | x-ray diffraction | R | — | — |
| 2XIR | Crystal structure of the VEGFR2 kinase domain in complex with PF- 00337210… | x-ray diffraction | A | — | — |
| 2XIR | Crystal structure of the VEGFR2 kinase domain in complex with pf- 00337210… | x-ray diffraction | A | — | — |
| 3B8Q | Crystal structure of the VEGFR2 kinase domain in complex with a naphthamide inhibitor | x-ray diffraction | A, B | — | — |
| 3B8Q | Crystal structure of the VEGFR2 kinase domain in complex with a naphthamide inhibitor | x-ray diffraction | A, B | — | — |
| 3B8R | Crystal structure of the VEGFR2 kinase domain in complex with a naphthamide inhibitor | x-ray diffraction | A, B | — | — |
| 3B8R | Crystal structure of the VEGFR2 kinase domain in complex with a naphthamide inhibitor | x-ray diffraction | A, B | — | — |
| 3BE2 | Crystal structure of the VEGFR2 kinase domain in complex with a benzamide inhibitor | x-ray diffraction | A | — | — |
| 3BE2 | Crystal structure of the VEGFR2 kinase domain in complex with a benzamide inhibitor | x-ray diffraction | A | — | — |
| 3C7Q | Structure of VEGFR2 kinase domain in complex with BIBF1120 | x-ray diffraction | A | — | — |
| 3C7Q | Structure of VEGFR2 kinase domain in complex with BIBF1120 | x-ray diffraction | A | — | — |
| 3CJF | Crystal structure of VEGFR2 in complex with a 3,4,5-trimethoxy aniline containing pyrimidine | x-ray diffraction | A | — | — |
| 3CJF | Crystal structure of VEGFR2 in complex with a 3,4,5-trimethoxy aniline containing pyrimidine | x-ray diffraction | A | — | — |
| 3CJG | Crystal structure of VEGFR2 in complex with a 3,4,5-trimethoxy aniline containing pyrimidine | x-ray diffraction | A | — | — |
| 3CJG | Crystal structure of VEGFR2 in complex with a 3,4,5-trimethoxy aniline containing pyrimidine | x-ray diffraction | A | — | — |
| 3CP9 | Crystal structure of the VEGFR2 kinase domain in complex with a pyridone inhibitor | x-ray diffraction | A, B | — | — |
| 3CP9 | Crystal structure of the VEGFR2 kinase domain in complex with a pyridone inhibitor | x-ray diffraction | A, B | — | — |
| 3CPB | Crystal structure of the VEGFR2 kinase domain in complex with a bisamide inhibitor | x-ray diffraction | A, B | — | — |
| 3CPB | Crystal structure of the VEGFR2 kinase domain in complex with a bisamide inhibitor | x-ray diffraction | A, B | — | — |
| 3CPC | Crystal structure of the VEGFR2 kinase domain in complex with a pyridone inhibitor | x-ray diffraction | A, B | — | — |
| 3CPC | Crystal structure of the VEGFR2 kinase domain in complex with a pyridone inhibitor | x-ray diffraction | A, B | — | — |
| 3DTW | Crystal structure of the VEGFR2 kinase domain in complex with a benzisoxazole inhibitor | x-ray diffraction | A, B | — | — |
| 3DTW | Crystal structure of the VEGFR2 kinase domain in complex with a benzisoxazole inhibitor | x-ray diffraction | A, B | — | — |
| 3EFL | Crystal structure of the VEGFR2 kinase domain in complex with motesanib | x-ray diffraction | A, B | — | — |
| 3EFL | Crystal structure of the VEGFR2 kinase domain in complex with motesanib | x-ray diffraction | A, B | — | — |
| 3EWH | Crystal structure of the VEGFR2 kinase domain in complex with a pyridyl-pyrimidine benzimidazole… | x-ray diffraction | A | — | — |
| 3EWH | Crystal structure of the VEGFR2 kinase domain in complex with a pyridyl-pyrimidine benzimidazole… | x-ray diffraction | A | — | — |
| 3KVQ | Crystal structure of VEGFR2 extracellular domain D7 | x-ray diffraction | A | — | — |
| 3KVQ | Crystal structure of VEGFR2 extracellular domain D7 | x-ray diffraction | A | — | — |
| 3S35 | Structural basis for the function of two anti-VEGF receptor antibodies | x-ray diffraction | X | — | — |
| 3S35 | Structural basis for the function of two anti-VEGF receptor antibodies | x-ray diffraction | X | — | — |
45 records more on the page itself.
Ligands
- F82 · 2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{N}-(1-propan-2-ylpyrazol-4-yl)ethanamide · in 2 records
- F88 · ~{N}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide · in 2 records
- 5T2 · 2-(pyridin-4-ylmethylamino)-~{N}-[3-(trifluoromethyl)phenyl]benzamide · in 1 record
- CA · Calcium ion · in 1 record
- F8B · ~{N}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide · in 1 record
- GLC · alpha-D-glucopyranose · in 1 record
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 1 record
- O35 · ~{N}-[3-[(dimethylamino)methyl]-5-methyl-phenyl]-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide · in 1 record
- O3E · ~{N}-(4,4-dimethyl-2-prop-1-ynyl-3,1-benzoxazin-6-yl)-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide · in 1 record
Experiment against prediction
- 2QU6 chain B against the predicted model P35968: TM-score 0.98, RMSD 0.98 Å
- 2QU6 chain B against the predicted model P35968: TM-score 0.98, RMSD 0.98 Å
- 3CPB chain B against the predicted model P35968: TM-score 0.98, RMSD 1.00 Å
- 3CPB chain B against the predicted model P35968: TM-score 0.98, RMSD 1.00 Å
- 3B8R chain B against the predicted model P35968: TM-score 0.98, RMSD 1.05 Å
- 3B8R chain B against the predicted model P35968: TM-score 0.98, RMSD 1.05 Å
- 3CPC chain B against the predicted model P35968: TM-score 0.97, RMSD 1.03 Å
- 3CPC chain B against the predicted model P35968: TM-score 0.97, RMSD 1.03 Å
- 5EW3 chain A against the predicted model P35968: TM-score 0.97, RMSD 1.08 Å
- 3EFL chain B against the predicted model P35968: TM-score 0.97, RMSD 1.03 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.