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Ligand · 0KF

0KF · N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide

0KF, N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (C22 H21 N7 O3, 431.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding…

Component
0KF
Formula
C22 H21 N7 O3
Class
ligand
Structures
2
PDB entries
1

Binding sites

0KF in 2 structures; the first of them:

  • 3VO3 · Crystal Structure of the Kinase domain of Human VEGFR2 with imidazo[1,2-b]pyridazine… · 0KF A2001 · binds LEU840, VAL848, ALA866, LYS868, GLU885, ILE888, LEU889, ILE892 and 15 more
  • 3VO3 · Crystal structure of the kinase domain of human VEGFR2 with IMIDAZO[1, 2-B]PYRIDAZINE… · 0KF A2001 · binds LEU840, VAL848, ALA866, LYS868, GLU885, ILE888, LEU889, ILE892 and 15 more

Residues it binds most

VAL 2, ILE 2, LEU 2, PHE 2, CYS 2, GLU 2, LYS 2, ALA 2, ASP 2, GLY 2 (residue and the binding sites it lines).

Found with

  • EDO · 1,2-ethanediol

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