Research workbench
Structure of the human CAK in complex with THZ1
Analyse Structure of the human CAK in complex with THZ1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6XD3
- Type
- protein
- Length
- 644 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.3
- Source
- Homo sapiens
- Molecule
- CDK-activating kinase assembly factor MAT1; Cyclin-H; Cyclin-dependent kinase 7
- EC
- 2.7.11.22, 2.7.11.23
- UniProt
- P51948, P51946, P50613
- Ligands
- V0G
- Pockets
- 7 · best druggability 0.73
Structure
electron microscopy · resolution 3.3 · 3 distinct chains · 49% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | CDK-activating kinase assembly factor MAT1 | protein | 65 | 31% helix, 0% strand | P51948 |
| I | Cyclin-H | protein | 281 | 69% helix, 0% strand | P51946 |
| J | Cyclin-dependent kinase 7 (EC 2.7.11.22, 2.7.11.23) | protein | 298 | 33% helix, 15% strand | P50613 |
Ligands and binding sites
- V0G · N-(3-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)-4-{[4-(dimethylamino) butanoyl]amino}benzamide · ligand · chains J
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 442 | 0.73 | 0.83 | 67 | empty |
| 2 | 482 | 0.68 | 0.79 | 44 | empty |
| 3 | 298 | 0.63 | 0.80 | 35 | V0G |
| 4 | 137 | 0.56 | 0.83 | 25 | empty |
| 5 | 60 | 0.32 | 0.76 | 10 | empty |
Interfaces
3 interfaces between chains.
- H–I · 1294 Ų buried · 6 hydrogen bonds · protein-protein
- H–J · 1226 Ų buried · 6 hydrogen bonds · protein-protein
- I–J · 1219 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 covalent, 1 modified (covalent ligand, phosphorylation).
Compared structures
- 6XD3 · Structure of the human cak in complex with THZ1 · the same entry in another collection · chain H against H, TM-score 1.00
- P51946 · AlphaFold monomer V2.0 prediction for cyclin-H (P51946) · a predicted model of the same protein · chain I against A, TM-score 0.99
- P50613 · AlphaFold monomer V2.0 prediction for cyclin-dependent kinase 7 (P50613) · a predicted model of the same protein · chain J against A, TM-score 0.92
- P51948 · AlphaFold monomer V2.0 prediction for cdk-activating kinase assembly factor MAT1 (P51948) · a predicted model of the same protein · chain H against A, TM-score 0.78
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P51948
- Every structure of UniProt P51946
- Every structure of UniProt P50613
- Elsewhere: RCSB PDB 6XD3 · PDBe 6XD3 · UniProt P51948 · UniProt P51946 · UniProt P50613
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.