UniProt P51946
Cyclin-H (P51946)
Cyclin-H (UniProt P51946): 38 experimental structures and 1 predicted model on GenesisL1, 117 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P51946
- Protein
- Cyclin-H
- Experimental structures
- 38
- Predicted models
- 1
- Pockets
- 117 · 22 records with a druggable one
Structures
39 records of P51946 in the MolNFT archive: 38 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1JKW | Structure of cyclin MCS2 | x-ray diffraction | A | — | — |
| 1JKW | Structure of cyclin MCS2 | x-ray diffraction | A | — | — |
| 1KXU | Cyclin H, a positive regulatory subunit of cdk activating kinase | x-ray diffraction | A | — | — |
| 1KXU | Cyclin H, a positive regulatory subunit of cdk activating kinase | x-ray diffraction | A | — | — |
| 6O9L | Human holo-pic in the closed state | electron microscopy | 9 | — | — |
| 6XBZ | Structure of the human CDK-activating kinase | electron microscopy | I | — | 7 (best 0.76) |
| 6XBZ | Structure of the human cdk-activating kinase | electron microscopy | I | — | — |
| 6XD3 | Structure of the human CAK in complex with THZ1 | electron microscopy | I | — | — |
| 6XD3 | Structure of the human cak in complex with THZ1 | electron microscopy | I | — | — |
| 7B5O | Cryo-EM structure of the human cak bound to ICEC0942 at 2.5 ångströms resolution | electron microscopy | I | — | — |
| 7B5Q | Cryo-EM structure of the human CAK bound to ICEC0942 (PHENIX-OPLS3e) | electron microscopy | I | — | — |
| 7B5Q | Cryo-EM structure of the human cak bound to ICEC0942 (phenix-OPLS3E) | electron microscopy | I | — | — |
| 7EGB | TFIID-based holo PIC on SCP promoter | electron microscopy | 9 | — | 1 (best 0.77) |
| 7EGC | p53-bound TFIID-based holo PIC on HDM2 promoter | electron microscopy | 9 | — | — |
| 7ENA | TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED) | electron microscopy | 9 | — | — |
| 7ENC | TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED) | electron microscopy | 9 | — | — |
| 7NVR | Human Mediator with RNA Polymerase II Pre-initiation complex | electron microscopy | 9 | — | — |
| 7NVR | Human mediator with RNA polymerase II pre-initiation complex | electron microscopy | 9 | — | — |
| 8BVW | RNA polymerase II pre-initiation complex with the distal +1 nucleosome (PIC-Nuc18W) | electron microscopy | 9 | — | 1 (best 0.82) |
| 8BYQ | RNA polymerase II pre-initiation complex with the proximal +1 nucleosome (PIC-Nuc10W) | electron microscopy | 9 | — | 1 (best 0.78) |
| 8GXQ | PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state | electron microscopy | HJ | — | 1 (best 0.82) |
| 8ORM | Cryo-EM structure of CAK-THZ1 | electron microscopy | I | — | 7 (best 0.76) |
| 8P6V | Cryo-EM structure of CAK in complex with inhibitor ICEC0942 | electron microscopy | I | — | 4 (best 0.73) |
| 8P6W | Cryo-EM structure of CAK in complex with inhibitor BS-181 | electron microscopy | I | — | 5 (best 0.76) |
| 8P6X | Cryo-EM structure of CAK in complex with inhibitor BS-194 | electron microscopy | I | — | 7 (best 0.75) |
| 8P6Z | Cryo-EM structure of CAK in complex with inhibitor ICEC0510-R | electron microscopy | I | — | 6 (best 0.74) |
| 8P70 | Cryo-EM structure of CAK in complex with inhibitor ICEC0510-S | electron microscopy | I | — | 6 (best 0.77) |
| 8P71 | Cryo-EM structure of CAK in complex with inhibitor ICEC0574 | electron microscopy | I | — | 5 (best 0.76) |
| 8P72 | Cryo-EM structure of CAK in complex with inhibitor ICEC0768 | electron microscopy | I | — | 5 (best 0.74) |
| 8P73 | Cryo-EM structure of CAK in complex with inhibitor ICEC0829 | electron microscopy | I | — | 5 (best 0.77) |
| 8P74 | Cryo-EM structure of CAK in complex with inhibitor ICEC0880 (ring-up conformation) | electron microscopy | I | — | 5 (best 0.75) |
| 8P75 | Cryo-EM structure of CAK in complex with inhibitor ICEC0880 (ring-down conformation) | electron microscopy | I | — | 6 (best 0.76) |
| 8P77 | Cryo-EM structure of CAK in complex with inhibitor ICEC0943 | electron microscopy | I | — | 5 (best 0.74) |
| 8P78 | Cryo-EM structure of CAK in complex with inhibitor dinaciclib | electron microscopy | I | — | 6 (best 0.74) |
| 8PLZ | Cryo-EM structure of CAK in complex with inhibitor CT7030 | electron microscopy | I | — | 5 (best 0.74) |
| 8PYR | Crystal structure of the dual T-loop phosphorylated Cdk7/CycH/Mat1 complex | x-ray diffraction | B, F | — | 17 (best 0.78) |
| 8S0R | Cryo-EM structure of CAK modified by covalent inhibitor SY-1365 | electron microscopy | I | — | 7 (best 0.74) |
| 8S0T | Cryo-EM structure of CAK in complex with SY-5609 | electron microscopy | I | — | 5 (best 0.71) |
| P51946 | AlphaFold monomer V2.0 prediction for cyclin-H (P51946) | predicted | A | — | — |
Experiment against prediction
- 8P75 chain I against the predicted model P51946: TM-score 0.99, RMSD 0.61 Å
- 8ORM chain I against the predicted model P51946: TM-score 0.99, RMSD 0.63 Å
- 8P6X chain I against the predicted model P51946: TM-score 0.99, RMSD 0.64 Å
- 8P77 chain I against the predicted model P51946: TM-score 0.99, RMSD 0.65 Å
- 7B5Q chain I against the predicted model P51946: TM-score 0.99, RMSD 0.66 Å
- 7B5Q chain I against the predicted model P51946: TM-score 0.99, RMSD 0.66 Å
- 8P78 chain I against the predicted model P51946: TM-score 0.99, RMSD 0.67 Å
- 8P6Z chain I against the predicted model P51946: TM-score 0.99, RMSD 0.66 Å
- 7B5O chain I against the predicted model P51946: TM-score 0.99, RMSD 0.67 Å
- 8P74 chain I against the predicted model P51946: TM-score 0.99, RMSD 0.67 Å
Elsewhere
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