UniProt P51948
CDK-activating kinase assembly factor MAT1 (P51948)
CDK-activating kinase assembly factor MAT1 (UniProt P51948): 43 experimental structures on GenesisL1, 1 ligand bound, 38 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P51948
- Protein
- CDK-activating kinase assembly factor MAT1
- Experimental structures
- 43
- Predicted models
- 0
- Ligands
- 1
- Pockets
- 38 · 16 records with a druggable one
Structures
43 records of P51948 in the MolNFT archive: 43 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1G25 | Solution structure of the N-terminal domain of the human tfiih MAT1 subunit | solution nmr | A | — | — |
| 1G25 | Solution structure of the N-terminal domain of the human tfiih MAT1 subunit | solution nmr | A | — | — |
| 6NMI | Cryo-EM structure of the human TFIIH core complex | electron microscopy | H | ZN | — |
| 6NMI | Cryo-EM structure of the human tfiih core complex | electron microscopy | H | ZN | — |
| 6O9L | Human holo-pic in the closed state | electron microscopy | 3 | ZN | — |
| 6O9M | Structure of the human apo tfiih | electron microscopy | 3 | ZN | — |
| 6TUN | Helicase domain complex | x-ray diffraction | D, C | — | 7 (best 0.61) |
| 6TUN | Helicase domain complex | x-ray diffraction | D, C | — | — |
| 6XBZ | Structure of the human cdk-activating kinase | electron microscopy | H | — | — |
| 6XD3 | Structure of the human CAK in complex with THZ1 | electron microscopy | H | — | — |
| 6XD3 | Structure of the human cak in complex with THZ1 | electron microscopy | H | — | — |
| 7B5O | Cryo-EM structure of the human cak bound to ICEC0942 at 2.5 ångströms resolution | electron microscopy | H | — | — |
| 7B5Q | Cryo-EM structure of the human CAK bound to ICEC0942 (PHENIX-OPLS3e) | electron microscopy | H | — | — |
| 7B5Q | Cryo-EM structure of the human cak bound to ICEC0942 (phenix-OPLS3E) | electron microscopy | H | — | — |
| 7EGB | TFIID-based holo PIC on SCP promoter | electron microscopy | 0 | ZN | 1 (best 0.77) |
| 7EGC | p53-bound TFIID-based holo PIC on HDM2 promoter | electron microscopy | 0 | ZN | — |
| 7ENA | TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED) | electron microscopy | 0 | ZN | — |
| 7ENC | TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED) | electron microscopy | 0 | ZN | — |
| 7NVR | Human Mediator with RNA Polymerase II Pre-initiation complex | electron microscopy | 3 | ZN | — |
| 7NVR | Human mediator with RNA polymerase II pre-initiation complex | electron microscopy | 3 | ZN | — |
| 7NVW | Tfiih in a pre-translocated state (without ADP-BEF3) | electron microscopy | 3 | ZN | — |
| 7NVX | Tfiih in a post-translocated state (with ADP-BEF3) | electron microscopy | 3 | ZN | — |
| 7NVY | RNA polymerase II pre-initiation complex with closed promoter DNA in proximal position | electron microscopy | 3 | ZN | — |
| 7NVZ | RNA polymerase II pre-initiation complex with closed promoter DNA in distal position | electron microscopy | 3 | ZN | — |
| 7NW0 | RNA polymerase II pre-initiation complex with open promoter DNA | electron microscopy | 3 | — | — |
| 7NW0 | RNA polymerase II pre-initiation complex with open promoter DNA | electron microscopy | 3 | — | — |
| 8BVW | RNA polymerase II pre-initiation complex with the distal +1 nucleosome (PIC-Nuc18W) | electron microscopy | 7 | ZN | 2 (best 0.82) |
| 8GXQ | PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state | electron microscopy | HD | ZN | 1 (best 0.82) |
| 8ORM | Cryo-EM structure of CAK-THZ1 | electron microscopy | H | — | 2 (best 0.76) |
| 8P6V | Cryo-EM structure of CAK in complex with inhibitor ICEC0942 | electron microscopy | H | — | 2 (best 0.73) |
| 8P6W | Cryo-EM structure of CAK in complex with inhibitor BS-181 | electron microscopy | H | — | 2 (best 0.76) |
| 8P71 | Cryo-EM structure of CAK in complex with inhibitor ICEC0574 | electron microscopy | H | — | 2 (best 0.76) |
| 8P72 | Cryo-EM structure of CAK in complex with inhibitor ICEC0768 | electron microscopy | H | — | 2 (best 0.74) |
| 8P73 | Cryo-EM structure of CAK in complex with inhibitor ICEC0829 | electron microscopy | H | — | 2 (best 0.77) |
| 8P77 | Cryo-EM structure of CAK in complex with inhibitor ICEC0943 | electron microscopy | H | — | 2 (best 0.74) |
| 8P78 | Cryo-EM structure of CAK in complex with inhibitor dinaciclib | electron microscopy | H | — | 2 (best 0.74) |
| 8PLZ | Cryo-EM structure of CAK in complex with inhibitor CT7030 | electron microscopy | H | — | 2 (best 0.74) |
| 8PYR | Crystal structure of the dual T-loop phosphorylated Cdk7/CycH/Mat1 complex | x-ray diffraction | C, G | — | 4 (best 0.78) |
| 8S0R | Cryo-EM structure of CAK modified by covalent inhibitor SY-1365 | electron microscopy | H | — | 3 (best 0.74) |
| 8S0T | Cryo-EM structure of CAK in complex with SY-5609 | electron microscopy | H | — | 2 (best 0.71) |
| 8WAO | Structure of transcribing complex 5 (TC5), the initially transcribing complex with Pol II… | electron microscopy | 0 | ZN | — |
| 8WAQ | Structure of transcribing complex 7 (TC7), the initially transcribing complex with Pol II… | electron microscopy | 0 | ZN | — |
| P51948 | AlphaFold monomer V2.0 prediction for cdk-activating kinase assembly factor MAT1 (P51948) | — | — | — |
Ligands
- ZN · Zinc ion · in 18 records
Elsewhere
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