Research workbench
Structure of Inactive E165Q mutant of fungal non-CBM carrying GH26 endo-b-mannanase from Yunnania penicillata in complex with alpha-62-61-di-galactosyl-mannotriose
Analyse Structure of Inactive E165Q mutant of fungal non-CBM carrying GH26… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6HPF
- Type
- protein
- Length
- 312 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.36
- Source
- Yunnania penicillata
- Molecule
- endo-b-mannanase
- Ligands
- BMA, GLA, MAN, NAG, SO4, CL
- Pockets
- 2 · best druggability 0.33
Structure
x-ray diffraction · resolution 1.36 · 1 distinct chain · 43% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | endo-b-mannanase | protein | 312 | 43% helix, 15% strand | — |
Ligands and binding sites
- BMA · beta-D-mannopyranose · sugar · 2 copies · chains A
- GLA · alpha-D-galactopyranose · sugar · 2 copies · chains A
- MAN · alpha-D-mannopyranose · sugar · chains A
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A
- SO4 · Sulfate ion · ion · 6 copies · chains A
- CL · Chloride ion · ion · chains A
- ACY · Acetic acid · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 63 | 0.33 | 0.76 | 14 | empty |
| 2 | 58 | 0.28 | 0.74 | 22 | MAN, GLA, ACY |
Modifications
Observed in the structure: 1 glycan (N-glycosylation).
Compared structures
- 6HPF · Structure of inactive E165Q mutant of fungal non-cbm carrying GH26 endo-B-mannanase from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6HPF · PDBe 6HPF
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