MolNFT v1 · #151492 · protein
Structure of inactive E165Q mutant of fungal non-cbm carrying GH26 endo-B-mannanase from yunnania penicillata in complex with alpha-62- 61-di-galactosyl-mannotriose
6HPF: “Structure of inactive E165Q mutant of fungal non-cbm carrying GH26 endo-B-mannanase from yunnania penicillata…”. X-ray diffraction, 6 ligands (BMA, GLA, MAN), 2 pockets (best druggability 0.33). MolNFT v1 #151492 on GenesisL1: 3D…
- PDB
- 6HPF
- Type
- protein
- Length
- 312 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Endo-B-mannanase
- Ligands
- BMA, GLA, MAN, NAG, SO4, CL
- Pockets
- 2 · best druggability 0.33
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Endo-B-mannanase | protein | 312 | 43% helix, 15% strand | — |
Ligands and binding sites
- BMA · beta-D-mannopyranose · sugar · 2 copies · chains A
- GLA · alpha-D-galactopyranose · sugar · 2 copies · chains A
- MAN · alpha-D-mannopyranose · sugar · chains A
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A
- SO4 · Sulfate ion · ion · 6 copies · chains A
- CL · Chloride ion · ion · chains A
- ACY · Acetic acid · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 63 | 0.33 | 0.76 | 14 | empty |
| 2 | 58 | 0.28 | 0.74 | 22 | MAN, GLA, ACY |
Modifications
Observed in the structure: 1 glycan (N-glycosylation).
Compared structures
- 6HPF · Structure of Inactive E165Q mutant of fungal non-CBM carrying GH26 endo-b-mannanase from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6HPF · PDBe 6HPF
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