Research workbench
The neck-linker and alpha 7 helix of Homo sapiens Eg5 fused to EB1
Analyse The neck-linker and alpha 7 helix of Homo sapiens Eg5 fused to EB1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5JV3
- Type
- protein
- Length
- 263 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.006
- Source
- Homo sapiens
- Molecule
- Chimera protein of Kinesin-like protein KIF11 and Microtubule-associated protein RP/EB…
- UniProt
- P52732, Q15691
- Ligands
- CA
- Pockets
- 3 · best druggability 0.42
Structure
x-ray diffraction · resolution 2.006 · 4 distinct chains · 81% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chimera protein of Kinesin-like protein KIF11 and Microtubule-associated protein RP/EB family member 1 | protein | 62 | 82% helix, 0% strand | P52732, Q15691 |
| B | Chimera protein of Kinesin-like protein KIF11 and Microtubule-associated protein RP/EB family member 1 | protein | 69 | 78% helix, 3% strand | P52732, Q15691 |
| C | Chimera protein of Kinesin-like protein KIF11 and Microtubule-associated protein RP/EB family member 1 | protein | 64 | 81% helix, 0% strand | P52732, Q15691 |
| D | Chimera protein of Kinesin-like protein KIF11 and Microtubule-associated protein RP/EB family member 1 | protein | 68 | 81% helix, 0% strand | P52732, Q15691 |
Ligands and binding sites
- CA · Calcium ion · metal · chains D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 65 | 0.42 | 0.81 | 14 | empty |
| 2 | 74 | 0.34 | 0.75 | 13 | empty |
| 3 | 89 | 0.34 | 0.74 | 16 | empty |
Interfaces
4 interfaces between chains.
- C–D · 1810 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 1809 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 244 Ų buried · 2 hydrogen bonds · protein-protein
- A–C · 104 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5JV3 · The neck-linker and alpha 7 helix of homo sapiens EG5 fused to EB1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q15691 · AlphaFold monomer V2.0 prediction for microtubule-associated protein RP/EB family member… · a predicted model of the same protein · chain B against A, TM-score 0.83
- P52732 · AlphaFold monomer V2.0 prediction for kinesin-like protein KIF11 (P52732) · a predicted model of the same protein · chain A against A, TM-score 0.72
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52732
- Every structure of UniProt Q15691
- Elsewhere: RCSB PDB 5JV3 · PDBe 5JV3 · UniProt P52732 · UniProt Q15691
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