UniProt P52732
Kinesin-like protein KIF11 (P52732)
Kinesin-like protein KIF11 (UniProt P52732): 122 experimental structures and 1 predicted model on GenesisL1, 12 ligands bound, 66 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P52732
- Protein
- Kinesin-like protein KIF11
- Experimental structures
- 122
- Predicted models
- 1
- Ligands
- 12
- Pockets
- 66 · 10 records with a druggable one
Structures
123 records of P52732 in the MolNFT archive: 122 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1II6 | Crystal Structure of the Mitotic Kinesin Eg5 in Complex with Mg-ADP. | x-ray diffraction | A, B | — | — |
| 1II6 | Crystal structure of the mitotic kinesin EG5 in complex with mg-ADP. | x-ray diffraction | A, B | — | — |
| 1Q0B | Crystal structure of the motor protein KSP in complex with ADP and monastrol | x-ray diffraction | A, B | — | — |
| 1Q0B | Crystal structure of the motor protein ksp in complex with ADP and monastrol | x-ray diffraction | A, B | — | — |
| 1X88 | Human Eg5 motor domain bound to Mg-ADP and monastrol | x-ray diffraction | A, B | — | — |
| 1X88 | Human EG5 motor domain bound to mg-ADP and monastrol | x-ray diffraction | A, B | — | — |
| 1YRS | Crystal structure of KSP in complex with inhibitor 1 | x-ray diffraction | A, B | — | — |
| 1YRS | Crystal structure of ksp in complex with inhibitor 1 | x-ray diffraction | A, B | — | — |
| 2FKY | crystal structure of KSP in complex with inhibitor 13 | x-ray diffraction | A, B | — | — |
| 2FKY | Crystal structure of ksp in complex with inhibitor 13 | x-ray diffraction | A, B | — | — |
| 2FL2 | crystal structure of KSP in complex with inhibitor 19 | x-ray diffraction | A, B | — | — |
| 2FL2 | Crystal structure of ksp in complex with inhibitor 19 | x-ray diffraction | A, B | — | — |
| 2FL6 | crystal structure of KSP in complex with inhibitor 6 | x-ray diffraction | A, B | — | — |
| 2FL6 | Crystal structure of ksp in complex with inhibitor 6 | x-ray diffraction | A, B | — | — |
| 2FME | Crystal structure of the mitotic kinesin eg5 (ksp) in complex with mg-adp and… | x-ray diffraction | A, B | — | — |
| 2FME | Crystal structure of the mitotic kinesin EG5 (ksp) in complex with mg- ADP and… | x-ray diffraction | A, B | — | — |
| 2G1Q | crystal structure of KSP in complex with inhibitor 9h | x-ray diffraction | A, B | — | — |
| 2G1Q | Crystal structure of ksp in complex with inhibitor 9H | x-ray diffraction | A, B | — | — |
| 2GM1 | Crystal structure of the mitotic kinesin eg5 in complex with mg-adp and… | x-ray diffraction | A, B, D, E | — | — |
| 2GM1 | Crystal structure of the mitotic kinesin EG5 in complex with mg-ADP and… | x-ray diffraction | A, B, D, E | — | — |
| 2IEH | Crystal structure of human kinesin Eg5 in complex with (R)-mon97, a new monastrol-based inhibitor… | x-ray diffraction | A, B | — | — |
| 2IEH | Crystal structure of human kinesin EG5 in complex with (R)- MON97, a new monastrol-based inhibitor… | x-ray diffraction | A, B | — | — |
| 2PG2 | Crystal structure of KSP in complex with ADP and thiophene containing inhibitor 15 | x-ray diffraction | A, B | — | — |
| 2PG2 | Crystal structure of ksp in complex with ADP and thiophene containing inhibitor 15 | x-ray diffraction | A, B | — | — |
| 2Q2Y | Crystal Structure of KSP in complex with Inhibitor 1 | x-ray diffraction | A, B | — | — |
| 2Q2Y | Crystal structure of ksp in complex with inhibitor 1 | x-ray diffraction | A, B | — | — |
| 2Q2Z | Crystal Structure of KSP in Complex with Inhibitor 22 | x-ray diffraction | A, B | — | — |
| 2Q2Z | Crystal structure of ksp in complex with inhibitor 22 | x-ray diffraction | A, B | — | — |
| 2UYI | Crystal structure of KSP in complex with ADP and thiophene containing inhibitor 33 | x-ray diffraction | A, B | — | — |
| 2UYI | Crystal structure of ksp in complex with ADP and thiophene containing inhibitor 33 | x-ray diffraction | A, B | — | — |
| 2UYM | Crystal structure of KSP in complex with ADP and thiophene containing inhibitor 37 | x-ray diffraction | A, B | — | — |
| 2UYM | Crystal structure of ksp in complex with ADP and thiophene containing inhibitor 37 | x-ray diffraction | A, B | — | — |
| 2WOG | Intermediate and final states of human kinesin Eg5 in complex with S-trityl-L-cysteine | x-ray diffraction | A, B, C | — | — |
| 2WOG | Intermediate and final states of human kinesin EG5 in complex with S- trityl-L-cysteine | x-ray diffraction | A, B, C | — | — |
| 2X2R | Crystal structure of human kinesin Eg5 in complex with… | x-ray diffraction | A, B, C | — | — |
| 2X2R | Crystal structure of human kinesin EG5 in complex with… | x-ray diffraction | A, B, C | — | — |
| 2X7C | Crystal structure of human kinesin Eg5 in complex with (S)-enastron | x-ray diffraction | A, B | — | — |
| 2X7C | Crystal structure of human kinesin EG5 in complex with (S)-enastron | x-ray diffraction | A, B | — | — |
| 2X7D | Crystal structure of human kinesin Eg5 in complex with (S)-dimethylenastron | x-ray diffraction | A, B | — | — |
| 2X7D | Crystal structure of human kinesin EG5 in complex with (S)-dimethylenastron | x-ray diffraction | A, B | — | — |
| 2X7E | Crystal structure of human kinesin Eg5 in complex with (R)-fluorastrol | x-ray diffraction | A, B | — | — |
| 2X7E | Crystal structure of human kinesin EG5 in complex with (R)-fluorastrol | x-ray diffraction | A, B | — | — |
| 2XAE | Crystal structure of human kinesin Eg5 in complex with… | x-ray diffraction | A, B, C | — | — |
| 2XAE | Crystal structure of human kinesin EG5 in complex with… | x-ray diffraction | A, B, C | — | — |
| 3CJO | Crystal structure of KSP in complex with inhibitor 30 | x-ray diffraction | A, B | — | — |
| 3CJO | Crystal structure of ksp in complex with inhibitor 30 | x-ray diffraction | A, B | — | — |
| 3HQD | Human kinesin Eg5 motor domain in complex with AMPPNP and Mg2+ | x-ray diffraction | A, B | — | — |
| 3HQD | Human kinesin EG5 motor domain in complex with amppnp and MG2+ | x-ray diffraction | A, B | — | — |
| 3K3B | Co-crystal structure of the human kinesin Eg5 with a novel tetrahydro-beta-carboline | x-ray diffraction | A, B | — | — |
| 3K3B | Co-crystal structure of the human kinesin EG5 with a novel tetrahydro- beta-carboline | x-ray diffraction | A, B | — | — |
| 3K5E | The structure of human kinesin-like motor protein Kif11/KSP/Eg5 in complex with ADP and enastrol. | x-ray diffraction | A, B | — | — |
| 3K5E | The structure of human kinesin-like motor protein KIF11/KSP/EG5 in complex with ADP and enastrol. | x-ray diffraction | A, B | — | — |
| 3KEN | Human Eg5 in complex with S-trityl-L-cysteine | x-ray diffraction | A | — | — |
| 3KEN | Human EG5 in complex with S-trityl-L-cysteine | x-ray diffraction | A | — | — |
| 3L9H | X-ray structure of mitotic kinesin-5 (KSP, KIF11, Eg5)in complex with the… | x-ray diffraction | A, B | — | — |
| 3L9H | X-ray structure of mitotic kinesin-5 (ksp, KIF11, EG5)IN complex with the… | x-ray diffraction | A, B | — | — |
| 3WPN | Kinesin spindle protein Eg5 in complex with ATP-competitive inhibitor PVZB1194 | x-ray diffraction | A | — | — |
| 3WPN | Kinesin spindle protein EG5 in complex with ATP-competitive inhibitor PVZB1194 | x-ray diffraction | A | — | — |
| 3ZCW | Eg5 - New allosteric binding site | x-ray diffraction | A | — | — |
| 3ZCW | EG5 - new allosteric binding site | x-ray diffraction | A | — | — |
63 records more on the page itself.
Ligands
- MG · Magnesium ion · in 22 records
- ADP · Adenosine-5'-diphosphate · in 21 records
- SO4 · Sulfate ion · in 6 records
- 4C5 · (2R)-2-azanyl-3-[(4-methoxyphenyl)-diphenyl-methyl]sulfanyl-propanoic acid · in 4 records
- EOK · (~{N}~{Z})-~{N}-[(5~{S})-4-ethanoyl-5-methyl-5-phenyl-1,3,4-thiadiazolidin-2-ylidene]ethanamide · in 4 records
- GCE · (2~{S})-2-(3-azanylpropyl)-5-[2,5-bis(fluoranyl) phenyl]-~{N}-methoxy-~{N}-methyl-2-phenyl-1,3,4-thiadiazole-3-carboxamide · in 4 records
- MZK · 6-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1~{H}-quinolin-2-one · in 4 records
- NA · Sodium ion · in 4 records
- NO3 · Nitrate ion · in 4 records
- 5C5 · (2R)-2-azanyl-3-[[2-(4-methoxyphenyl)-2-tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaenyl]sulfanyl]propanoic acid · in 2 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 2 records
- CA · Calcium ion · in 1 record
Experiment against prediction
- 4AP0 chain D against the predicted model P52732: TM-score 0.97, RMSD 1.41 Å
- 6HKY chain B against the predicted model P52732: TM-score 0.97, RMSD 1.39 Å
- 6G6Y chain A against the predicted model P52732: TM-score 0.97, RMSD 1.40 Å
- 4A51 chain B against the predicted model P52732: TM-score 0.96, RMSD 1.45 Å
- 2GM1 chain D against the predicted model P52732: TM-score 0.96, RMSD 1.53 Å
- 2GM1 chain E against the predicted model P52732: TM-score 0.96, RMSD 1.53 Å
- 4AP0 chain C against the predicted model P52732: TM-score 0.96, RMSD 1.46 Å
- 4A51 chain D against the predicted model P52732: TM-score 0.96, RMSD 1.45 Å
- 6HKY chain A against the predicted model P52732: TM-score 0.96, RMSD 1.40 Å
- 4A51 chain A against the predicted model P52732: TM-score 0.96, RMSD 1.47 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.