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Ligand · G7X

G7X · Ispinesib mesilate

G7X, Ispinesib mesilate (C30 H33 Cl N4 O2, 517.1 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
G7X
Formula
C30 H33 Cl N4 O2
Class
ligand
Structures
4
PDB entries
2

Binding sites

G7X in 4 structures; the first of them:

  • 4A5Y · Intermediate state of human kinesin Eg5 in complex with Ispinesib · G7X A1365 · binds THR112, MET115, GLU116, GLY117, GLU118, ARG119, TRP127, ASP130 and 12 more
  • 4AP0 · The mitotic kinesin Eg5 in complex with Mg-ADP and ispinesib · G7X A2001 · binds MET115, GLU116, GLY117, GLU118, ARG119, TRP127, ASP130, ALA133 and 11 more
  • 4A5Y · Intermediate state of human kinesin EG5 in complex with ispinesib · G7X A1365 · binds THR112, MET115, GLU116, GLY117, GLU118, ARG119, TRP127, ASP130 and 12 more
  • 4AP0 · The mitotic kinesin EG5 in complex with mg-ADP and ispinesib · G7X A2001 · binds MET115, GLU116, GLY117, GLU118, ARG119, TRP127, ASP130, ALA133 and 11 more

Residues it binds most

GLU 14, LEU 14, ALA 14, ARG 14, GLY 14, ASP 14, ILE 14, PRO 14, TRP 14, TYR 14 (residue and the binding sites it lines).

Found with

  • ADP · Adenosine-5'-diphosphate
  • MG · Magnesium ion
  • CL · Chloride ion
  • PO4 · Phosphate ion

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