Research workbench
SET7/9 N265A in complex with AdoHcy and TAF10 peptide
Analyse SET7/9 N265A in complex with AdoHcy and TAF10 peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5EG2
- Type
- protein
- Length
- 249 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.55
- Source
- Homo sapiens; SYNTHETIC CONSTRUCT
- Molecule
- Histone-lysine N-methyltransferase SETD7; Transcription initiation factor TFIID subunit 10
- EC
- 2.1.1.43
- UniProt
- Q8WTS6, Q12962
- Ligands
- SAH, NA
- Pockets
- 1 · best druggability 0.47
Structure
x-ray diffraction · resolution 1.55 · 2 distinct chains · 11% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone-lysine N-methyltransferase SETD7 (EC 2.1.1.43) | protein | 243 | 12% helix, 40% strand | Q8WTS6 |
| B | Transcription initiation factor TFIID subunit 10 | protein | 6 | 0% helix, 17% strand | Q12962 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 181 | 0.47 | 0.76 | 28 | SAH |
Interfaces
1 interface between chains.
- A–B · 514 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (methylation).
Compared structures
- 5EG2 · SET7/9 N265A in complex with adohcy and TAF10 peptide · the same entry in another collection · chain A against A, TM-score 1.00
- Q8WTS6 · AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase SETD7 (Q8WTS6) · a predicted model of the same protein · chain A against A, TM-score 1.00
- Q12962 · AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit 10… · a predicted model of the same protein · chain B against A, TM-score 0.58
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8WTS6
- Every structure of UniProt Q12962
- Elsewhere: RCSB PDB 5EG2 · PDBe 5EG2 · UniProt Q8WTS6 · UniProt Q12962
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