UniProt Q8WTS6
Histone-lysine N-methyltransferase SETD7 (Q8WTS6)
Histone-lysine N-methyltransferase SETD7 (UniProt Q8WTS6): 64 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 2 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q8WTS6
- Protein
- Histone-lysine N-methyltransferase SETD7
- Experimental structures
- 64
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 2 · 0 records with a druggable one
Structures
65 records of Q8WTS6 in the MolNFT archive: 64 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1H3I | Crystal structure of the Histone Methyltransferase SET7/9 | x-ray diffraction | A, B | — | — |
| 1H3I | Crystal structure of the histone methyltransferase SET7/9 | x-ray diffraction | A, B | — | — |
| 1MT6 | Structure of histone H3 K4-specific methyltransferase SET7/9 with AdoHcy | x-ray diffraction | A | — | — |
| 1MT6 | Structure of histone H3 K4-specific methyltransferase SET7/9 with adohcy | x-ray diffraction | A | — | — |
| 1MUF | Structure of histone H3 K4-specific methyltransferase SET7/9 | x-ray diffraction | A | — | — |
| 1MUF | Structure of histone H3 K4-specific methyltransferase SET7/9 | x-ray diffraction | A | — | — |
| 1N6A | Structure of SET7/9 | x-ray diffraction | A | — | — |
| 1N6A | Structure of SET7/9 | x-ray diffraction | A | — | — |
| 1N6C | Structure of SET7/9 | x-ray diffraction | A | — | — |
| 1N6C | Structure of SET7/9 | x-ray diffraction | A | — | — |
| 1O9S | Crystal structure of a ternary complex of the human histone methyltransferase SET7/9 | x-ray diffraction | A, B | — | — |
| 1O9S | Crystal structure of a ternary complex of the human histone methyltransferase SET7/9 | x-ray diffraction | A, B | — | — |
| 1XQH | Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a… | x-ray diffraction | A, E | — | — |
| 1XQH | Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a… | x-ray diffraction | A, E | — | — |
| 2F69 | Ternary complex of SET7/9 bound to AdoHcy and a TAF10 peptide | x-ray diffraction | A | — | — |
| 2F69 | Ternary complex of SET7/9 bound to adohcy and a TAF10 peptide | x-ray diffraction | A | — | — |
| 3CBM | SET7/9-ER-AdoMet complex | x-ray diffraction | A | — | — |
| 3CBM | SET7/9-er-adomet complex | x-ray diffraction | A | — | — |
| 3CBO | SET7/9-ER-AdoHcy complex | x-ray diffraction | A | — | — |
| 3CBO | SET7/9-er-adohcy complex | x-ray diffraction | A | — | — |
| 3CBP | Set7/9-ER-Sinefungin complex | x-ray diffraction | A | — | — |
| 3CBP | SET7/9-er-sinefungin complex | x-ray diffraction | A | — | — |
| 3M53 | SET7/9 in complex with TAF10 peptide and AdoHcy | x-ray diffraction | A | — | — |
| 3M53 | SET7/9 in complex with TAF10 peptide and adohcy | x-ray diffraction | A | — | — |
| 3M54 | SET7/9 Y305F in complex with TAF10 peptide and AdoHcy | x-ray diffraction | A | — | — |
| 3M54 | SET7/9 Y305F in complex with TAF10 peptide and adohcy | x-ray diffraction | A | — | — |
| 3M55 | SET7/9 Y305F in complex with TAF10-K189me1 peptide and AdoHcy | x-ray diffraction | A | — | — |
| 3M55 | SET7/9 Y305F in complex with TAF10-K189ME1 peptide and adohcy | x-ray diffraction | A | — | — |
| 3M56 | SET7/9 Y305F in complex with TAF10-K189me2 peptide and AdoHcy | x-ray diffraction | A | — | — |
| 3M56 | SET7/9 Y305F in complex with TAF10-K189ME2 peptide and adohcy | x-ray diffraction | A | — | — |
| 3M57 | SET7/9 Y245A in complex with TAF10 peptide and AdoHcy | x-ray diffraction | A | — | — |
| 3M57 | SET7/9 Y245A in complex with TAF10 peptide and adohcy | x-ray diffraction | A | — | — |
| 3M58 | SET7/9 Y245A in complex with TAF10-K189me1 peptide and AdoHcy | x-ray diffraction | A | — | — |
| 3M58 | SET7/9 Y245A in complex with TAF10-K189ME1 peptide and adohcy | x-ray diffraction | A | — | — |
| 3M59 | SET7/9 Y245A in complex with TAF10-K189me2 peptide and AdoHcy | x-ray diffraction | A | — | — |
| 3M59 | SET7/9 Y245A in complex with TAF10-K189ME2 peptide and adohcy | x-ray diffraction | A | — | — |
| 3M5A | SET7/9 Y245A in complex with TAF10-K189me3 peptide and AdoHcy | x-ray diffraction | A | — | — |
| 3M5A | SET7/9 Y245A in complex with TAF10-K189ME3 peptide and adohcy | x-ray diffraction | A | — | — |
| 3OS5 | SET7/9-Dnmt1 K142me1 complex | x-ray diffraction | A | — | — |
| 3OS5 | SET7/9-DNMT1 K142ME1 complex | x-ray diffraction | A | — | — |
| 3VUZ | Crystal structure of histone methyltransferase SET7/9 in complex with AAM-1 | x-ray diffraction | A | — | — |
| 3VUZ | Crystal structure of histone methyltransferase SET7/9 in complex with aam-1 | x-ray diffraction | A | — | — |
| 3VV0 | Crystal structure of histone methyltransferase SET7/9 in complex with DAAM-3 | x-ray diffraction | A | — | — |
| 3VV0 | Crystal structure of histone methyltransferase SET7/9 in complex with daam-3 | x-ray diffraction | A | — | — |
| 4E47 | SET7/9 in complex with inhibitor (R)-(3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-1,2,3… | x-ray diffraction | A, B, C, D | — | — |
| 4E47 | SET7/9 in complex with inhibitor (R)-(3-(3-cyanophenyl)-1-oxo-1… | x-ray diffraction | A, B, C, D | — | — |
| 4J7F | SET7/9Y335pAF in complex with TAF10 peptide and AdoHcy | x-ray diffraction | A | — | — |
| 4J7F | SET7/9Y335PAF in complex with TAF10 peptide and adohcy | x-ray diffraction | A | — | — |
| 4J7I | SET7/9Y335F in complex with TAF10 peptide and AdoHcy | x-ray diffraction | A | — | — |
| 4J7I | SET7/9Y335F in complex with TAF10 peptide and adohcy | x-ray diffraction | A | — | — |
| 4J83 | SET7/9 in complex with TAF10K189A peptide and AdoMet | x-ray diffraction | A | — | — |
| 4J83 | SET7/9 in complex with TAF10K189A peptide and adomet | x-ray diffraction | A | — | — |
| 4J8O | SET7/9 in complex with TAF10K189A peptide and AdoHcy | x-ray diffraction | A | — | — |
| 4J8O | SET7/9 in complex with TAF10K189A peptide and adohcy | x-ray diffraction | A | — | — |
| 4JDS | SETD7 in complex with inhibitor PF-5426 and S-adenosyl-methionine | x-ray diffraction | A, B, C, D | — | — |
| 4JDS | SETD7 in complex with inhibitor pf-5426 and S-adenosyl-methionine | x-ray diffraction | A, B, C, D | — | — |
| 4JLG | SETD7 in complex with inhibitor (R)-PFI-2 and S-adenosyl-methionine | x-ray diffraction | A, B | — | — |
| 4JLG | SETD7 in complex with inhibitor (R)-pfi-2 and S-adenosyl-methionine | x-ray diffraction | A, B | — | — |
| 5AYF | Crystal structure of SET7/9 in complex with cyproheptadine | x-ray diffraction | A | — | — |
| 5AYF | Crystal structure of SET7/9 in complex with cyproheptadine | x-ray diffraction | A | — | — |
5 records more on the page itself.
Ligands
Experiment against prediction
- 5EG2 chain A against the predicted model Q8WTS6: TM-score 0.99, RMSD 0.35 Å
- 5EG2 chain A against the predicted model Q8WTS6: TM-score 0.99, RMSD 0.35 Å
- 4J7F chain A against the predicted model Q8WTS6: TM-score 0.99, RMSD 0.39 Å
- 4J7F chain A against the predicted model Q8WTS6: TM-score 0.99, RMSD 0.39 Å
- 4J83 chain A against the predicted model Q8WTS6: TM-score 0.99, RMSD 0.40 Å
- 4J83 chain A against the predicted model Q8WTS6: TM-score 0.99, RMSD 0.40 Å
- 3CBP chain A against the predicted model Q8WTS6: TM-score 0.99, RMSD 0.42 Å
- 3CBP chain A against the predicted model Q8WTS6: TM-score 0.99, RMSD 0.42 Å
- 1MUF chain A against the predicted model Q8WTS6: TM-score 0.99, RMSD 0.67 Å
- 1MUF chain A against the predicted model Q8WTS6: TM-score 0.99, RMSD 0.67 Å
Elsewhere
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