Research workbench
Crystal structure of spleen tyrosine kinase (Syk) in complex with an imidazopyrazine inhibitor
Analyse Crystal structure of spleen tyrosine kinase (Syk) in complex with an… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4PV0
- Type
- protein
- Length
- 268 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2
- Source
- Homo sapiens
- Molecule
- Tyrosine-protein kinase SYK
- EC
- 2.7.10.2
- UniProt
- P43405
- Ligands
- CG4, CL
- Pockets
- 1 · best druggability 0.64
Structure
x-ray diffraction · resolution 2 · 1 distinct chain · 41% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein kinase SYK (EC 2.7.10.2) | protein | 268 | 41% helix, 22% strand | P43405 |
Ligands and binding sites
- CG4 · 4-[(3-{8-[(3,4-dimethoxyphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}benzoyl)amino]benzoic acid · ligand · chains A
- CL · Chloride ion · ion · 5 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 383 | 0.64 | 0.78 | 37 | CG4 |
Compared structures
- 4PV0 · Crystal structure of spleen tyrosine kinase (syk) in complex with an imidazopyrazine… · the same entry in another collection · chain A against A, TM-score 1.00
- P43405 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase syk (P43405) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43405
- Elsewhere: RCSB PDB 4PV0 · PDBe 4PV0 · UniProt P43405
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