MolNFT v1 · #103912 · protein
Crystal structure of spleen tyrosine kinase (syk) in complex with an imidazopyrazine inhibitor
4PV0 · Tyrosine-protein kinase syk: “Crystal structure of spleen tyrosine kinase (syk) in complex with an imidazopyrazine inhibitor”. X-ray diffraction, 2 ligands (CG4, CL), 1 pocket (best druggability 0.64). MolNFT v1 #103912 on…
- PDB
- 4PV0
- Type
- protein
- Length
- 268 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein kinase syk
- EC
- 2.7.10.2
- UniProt
- P43405
- Ligands
- CG4, CL
- Pockets
- 1 · best druggability 0.64
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein kinase syk (EC 2.7.10.2) | protein | 268 | 41% helix, 22% strand | P43405 |
Ligands and binding sites
- CG4 · 4-[(3-{8-[(3,4-dimethoxyphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}benzoyl)amino]benzoic acid · ligand · chains A
- CL · Chloride ion · ion · 5 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 383 | 0.64 | 0.78 | 37 | CG4 |
Compared structures
- 4PV0 · Crystal structure of spleen tyrosine kinase (Syk) in complex with an imidazopyrazine… · the same entry in another collection · chain A against A, TM-score 1.00
- P43405 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase syk (P43405) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43405
- Elsewhere: RCSB PDB 4PV0 · PDBe 4PV0 · UniProt P43405
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