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AlphaFold monomer V2.0 prediction for protein translocase subunit secy (P0AGA2)

Analyse AlphaFold monomer V2.0 prediction for protein translocase subunit secy (P0AGA2) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

Accession
P0AGA2
Type
protein
Length
443 residues
Chains
1
Collection
MolNFT v1 / AlphaFold
Contract
0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner
0xf4ED13986579E8e227b3ED6c02276c648754EC27
Molecule
Protein translocase subunit secy
UniProt
P0AGA2
Pockets
6 · best druggability 0.71

Structure

1 distinct chain · 70% helix, 6% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AProtein translocase subunit secyprotein44370% helix, 6% strandP0AGA2

Pockets

6 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
1670.710.9623empty
25630.690.7951empty
32600.690.8436empty
42060.620.8222empty
51580.570.8124empty

Compared structures

  • 5NCO · Quaternary complex between SRP, SR, and SecYEG bound to the translating ribosome · an experimental structure of the same protein · chain A against g, TM-score 0.83
  • 5GAE · RNC in complex with a translocating SecYEG · an experimental structure of the same protein · chain A against g, TM-score 0.82
  • 5GAE · Rnc in complex with a translocating secyeg · an experimental structure of the same protein · chain A against g, TM-score 0.82
  • 6R7L · Ribosome-bound secyeg translocon in a nanodisc · an experimental structure of the same protein · chain A against Y, TM-score 0.82
  • 6R7L · Ribosome-bound SecYEG translocon in a nanodisc · an experimental structure of the same protein · chain A against Y, TM-score 0.82
  • 3J45 · Structure of a non-translocating SecY protein channel with the 70S ribosome · an experimental structure of the same protein · chain A against y, TM-score 0.79
  • 3J45 · Structure of a non-translocating secy protein channel with the 70S ribosome · an experimental structure of the same protein · chain A against y, TM-score 0.79
  • 3J46 · Structure of the secy protein translocation channel in action · an experimental structure of the same protein · chain A against y, TM-score 0.60
  • 3J46 · Structure of the SecY protein translocation channel in action · an experimental structure of the same protein · chain A against y, TM-score 0.60
  • 5MG3 · EM fitted model of bacterial holo-translocon · an experimental structure of the same protein · chain A against Y, TM-score 0.60
  • 5MG3 · EM fitted model of bacterial holo-translocon · an experimental structure of the same protein · chain A against Y, TM-score 0.60

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