Research workbench
AlphaFold monomer V2.0 prediction for 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (P19174)
Analyse AlphaFold monomer V2.0 prediction for 1-phosphatidylinositol 4,5-bisphosphate… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P19174
- Type
- protein
- Length
- 1,290 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xf849160D6081641c43ABA768B2b1C10AD3F94E20
- Molecule
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
- UniProt
- P19174
- Pockets
- 19 · best druggability 0.82
Structure
1 distinct chain · 26% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | protein | 1290 | 26% helix, 26% strand | P19174 |
Pockets
19 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 936 | 0.82 | 0.83 | 94 | empty |
| 2 | 1036 | 0.81 | 0.82 | 77 | empty |
| 3 | 906 | 0.77 | 0.80 | 95 | empty |
| 4 | 173 | 0.59 | 0.82 | 27 | empty |
| 5 | 275 | 0.58 | 0.78 | 33 | empty |
Compared structures
- 4EY0 · Structure of tandem SH2 domains from PLCgamma1 · an experimental structure of the same protein · chain A against A, TM-score 0.18
- 4EY0 · Structure of tandem SH2 domains from PLCGAMMA1 · an experimental structure of the same protein · chain A against A, TM-score 0.18
- 4FBN · Insights into structural integration of the plcgamma regulatory region and mechanism of… · an experimental structure of the same protein · chain A against A, TM-score 0.18
- 4FBN · Insights into structural integration of the PLCgamma regulatory region and mechanism of… · an experimental structure of the same protein · chain A against A, TM-score 0.18
- 7NXE · Structure of the Phospholipase C gamma 1 tSH2 domain in complex with a phosphorylated… · an experimental structure of the same protein · chain A against A, TM-score 0.17
- 7NXE · Structure of the phospholipase C gamma 1 TSH2 domain in complex with a phosphorylated… · an experimental structure of the same protein · chain A against A, TM-score 0.17
- 1HSQ · Solution structure of the SH3 domain of phospholipase cgamma · an experimental structure of the same protein · chain A against A, TM-score 0.05
- 1HSQ · Solution structure of the SH3 domain of phospholipase cgamma · an experimental structure of the same protein · chain A against A, TM-score 0.05
- 2HSP · Solution structure of the SH3 domain of phospholipase cgamma · an experimental structure of the same protein · chain A against A, TM-score 0.05
- 2HSP · Solution structure of the SH3 domain of phospholipase cgamma · an experimental structure of the same protein · chain A against A, TM-score 0.05
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19174
- Elsewhere: UniProt P19174 · AlphaFold DB P19174
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