MolNFT v1 · #90914 · protein
Structure of tandem SH2 domains from PLCGAMMA1
4EY0 · 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase…: “Structure of tandem SH2 domains from PLCGAMMA1”. X-ray diffraction, 9 pockets (best druggability 0.73). MolNFT v1 #90914 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4EY0
- Type
- protein
- Length
- 940 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
- EC
- 3.1.4.11
- UniProt
- P19174
- Pockets
- 9 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 23% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) | protein | 235 | 23% helix, 34% strand | P19174 |
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1181 | 0.73 | 0.77 | 135 | empty |
| 2 | 757 | 0.68 | 0.75 | 64 | empty |
| 3 | 682 | 0.67 | 0.76 | 59 | empty |
| 4 | 302 | 0.51 | 0.74 | 33 | empty |
| 5 | 200 | 0.46 | 0.74 | 24 | empty |
Interfaces
6 interfaces between chains.
- A–B · 517 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 502 Ų buried · 7 hydrogen bonds · protein-protein
- A–D · 502 Ų buried · 7 hydrogen bonds · protein-protein
- C–D · 482 Ų buried · 3 hydrogen bonds · protein-protein
- B–D · 16 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (phosphorylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19174
- Elsewhere: RCSB PDB 4EY0 · PDBe 4EY0 · UniProt P19174
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