MolNFT v1 · #91381 · protein

Insights into structural integration of the plcgamma regulatory region and mechanism of autoinhibition and activation based on key roles of SH2 domains

4FBN · 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase…: “Insights into structural integration of the plcgamma regulatory region and mechanism of autoinhibition and…”. X-ray diffraction, 1 pocket (best druggability 0.44). MolNFT…

PDB: 4FBN
Type: protein
Length: 232 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
EC: 3.1.4.11
UniProt: P19174
Pockets: 1 · best druggability 0.44

Structure

x-ray diffraction · 1 distinct chain · 25% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11)	protein	232	25% helix, 31% strand	P19174

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	125	0.44	0.77	23	empty

Compared structures

4FBN · Insights into structural integration of the PLCgamma regulatory region and mechanism of… · the same entry in another collection · chain A against A, TM-score 1.00
P19174 · AlphaFold monomer V2.0 prediction for 1-phosphatidylinositol 4,5-bisphosphate… · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P19174
Elsewhere: RCSB PDB 4FBN · PDBe 4FBN · UniProt P19174

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