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Insights into structural integration of the plcgamma regulatory region and mechanism of autoinhibition and activation based on key roles of SH2 domains

Analyse Insights into structural integration of the plcgamma regulatory region and… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4FBN
Type: protein
Length: 232 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
EC: 3.1.4.11
UniProt: P19174
Pockets: 1 · best druggability 0.44

Structure

x-ray diffraction · 1 distinct chain · 25% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11)	protein	232	25% helix, 31% strand	P19174

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	125	0.44	0.77	23	empty

Compared structures

4FBN · Insights into structural integration of the PLCgamma regulatory region and mechanism of… · the same entry in another collection · chain A against A, TM-score 1.00
P19174 · AlphaFold monomer V2.0 prediction for 1-phosphatidylinositol 4,5-bisphosphate… · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P19174
Elsewhere: RCSB PDB 4FBN · PDBe 4FBN · UniProt P19174

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