UniProt Q9Y468
Lethal(3)malignant brain tumor-like protein 1 (Q9Y468)
Lethal(3)malignant brain tumor-like protein 1 (UniProt Q9Y468): 40 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 9 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q9Y468
- Protein
- Lethal(3)malignant brain tumor-like protein 1
- Experimental structures
- 40
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 9 · 2 records with a druggable one
Structures
41 records of Q9Y468 in the MolNFT archive: 40 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1OYX | Crystal structure of 3-mbt repeats of lethal (3) malignant brain tumor (seleno-met) at 1.85 ångström | x-ray diffraction | A, B, C | — | — |
| 1OYX | Crystal structure of 3-mbt repeats of lethal (3) malignant brain tumor (seleno-met) at 1.85 ångström | x-ray diffraction | A, B, C | — | — |
| 1OZ2 | Crystal structure of 3-mbt repeats of lethal (3) malignant brain tumor (native-II) at 1.55 ångström | x-ray diffraction | A | — | — |
| 1OZ2 | Crystal structure of 3-mbt repeats of lethal (3) malignant brain tumor (native-II) at 1.55 ångström | x-ray diffraction | A | — | — |
| 1OZ3 | Crystal Structure of 3-MBT repeats of lethal (3) malignant Brain Tumor (Native-I) at 1.85 angstrom | x-ray diffraction | A, B, C | — | — |
| 1OZ3 | Crystal structure of 3-mbt repeats of lethal (3) malignant brain tumor (native-I) at 1.85 ångström | x-ray diffraction | A, B, C | — | — |
| 2PQW | Crystal structure of L3MBTL1 in complex with H4K20Me2 (residues 17-25), trigonal form | x-ray diffraction | A | — | — |
| 2PQW | Crystal structure of L3MBTL1 in complex with H4K20ME2 (residues 17- 25), trigonal form | x-ray diffraction | A | — | — |
| 2RHI | Crystal structure of the 3-MBT domain from human L3MBTL1 in complex with H1.5K27me2 at 1.66 angstrom | x-ray diffraction | A | — | — |
| 2RHI | Crystal structure of the 3-mbt domain from human L3MBTL1 in complex with H1.5K27ME2 at 1.66 ångström | x-ray diffraction | A | — | — |
| 2RHU | Crystal structure of the 3-MBT repeats from human L3MBTL1 bound to dimethyl-lysine and in chimera… | x-ray diffraction | A | — | — |
| 2RHU | Crystal structure of the 3-mbt repeats from human L3MBTL1 bound to dimethyl-lysine and in chimera… | x-ray diffraction | A | — | — |
| 2RHX | Crystal structure of the 3-MBT repeats from human L3MBTL1 bound to dimethyl-lysine | x-ray diffraction | A | — | — |
| 2RHX | Crystal structure of the 3-mbt repeats from human L3MBTL1 bound to dimethyl-lysine | x-ray diffraction | A | — | — |
| 2RHY | Crystal structure of the 3-MBT repeats from human L3MBTL1 bound to monomethyl-lysine | x-ray diffraction | A | — | — |
| 2RHY | Crystal structure of the 3-mbt repeats from human L3MBTL1 bound to monomethyl-lysine | x-ray diffraction | A | — | — |
| 2RHZ | Crystal structure of the 3-MBT repeats from human L3MBTL1 with D355N point mutation | x-ray diffraction | A | — | — |
| 2RHZ | Crystal structure of the 3-mbt repeats from human L3MBTL1 with D355N point mutation | x-ray diffraction | A | — | — |
| 2RI2 | Crystal structure of the 3-MBT repeats from human L3MBTL1 with D355A point mutation | x-ray diffraction | A | — | — |
| 2RI2 | Crystal structure of the 3-mbt repeats from human L3MBTL1 with D355A point mutation | x-ray diffraction | A | — | — |
| 2RI3 | Crystal structure of the 3-MBT repeats from human L3MBTL1 with N358Q point mutation | x-ray diffraction | A | — | — |
| 2RI3 | Crystal structure of the 3-mbt repeats from human L3MBTL1 with N358Q point mutation | x-ray diffraction | A | — | — |
| 2RI5 | Crystal structure of the 3-MBT repeats from human L3MBTL1 with N358A point mutation | x-ray diffraction | A | — | — |
| 2RI5 | Crystal structure of the 3-mbt repeats from human L3MBTL1 with N358A point mutation | x-ray diffraction | A | — | — |
| 2RJC | Crystal structure of L3MBTL1 protein in complex with MES | x-ray diffraction | A, B, C | — | — |
| 2RJC | Crystal structure of L3MBTL1 protein in complex with mes | x-ray diffraction | A, B, C | — | — |
| 2RJD | Crystal structure of L3MBTL1 protein | x-ray diffraction | A | — | — |
| 2RJD | Crystal structure of L3MBTL1 protein | x-ray diffraction | A | — | — |
| 2RJE | Crystal structure of L3MBTL1 in complex with H4K20Me2 (residues 17-25), orthorhombic form II | x-ray diffraction | A, B, C | — | — |
| 2RJE | Crystal structure of L3MBTL1 in complex with H4K20ME2 (residues 17- 25), orthorhombic form II | x-ray diffraction | A, B, C | — | — |
| 2RJF | Crystal structure of L3MBTL1 in complex with H4K20Me2 (residues 12-30), orthorhombic form I | x-ray diffraction | A, C, E | — | — |
| 2RJF | Crystal structure of L3MBTL1 in complex with H4K20ME2 (residues 12- 30), orthorhombic form I | x-ray diffraction | A, C, E | — | — |
| 3OQ5 | Crystal structure of the 3-MBT domain from human L3MBTL1 in complex with p53K382me1 | x-ray diffraction | A, B, C | — | — |
| 3OQ5 | Crystal structure of the 3-mbt domain from human L3MBTL1 in complex with P53K382ME1 | x-ray diffraction | A, B, C | — | — |
| 3P8H | Crystal structure of L3MBTL1 (MBT repeat) in complex with a nicotinamide antagonist | x-ray diffraction | A, B, C | — | — |
| 3P8H | Crystal structure of L3MBTL1 (mbt repeat) in complex with a nicotinamide antagonist | x-ray diffraction | A, B, C | — | — |
| 3UWN | The 3-MBT repeat domain of L3MBTL1 in complex with a methyl-lysine mimic | x-ray diffraction | A | — | — |
| 3UWN | The 3-mbt repeat domain of L3MBTL1 in complex with a methyl-lysine mimic | x-ray diffraction | A | — | — |
| 6BYB | Crystal structure of L3MBTL1 MBT Domain with MBK14970 | x-ray diffraction | A | EC7, UNX | 2 (best 0.70) |
| 6BYB | Crystal structure of L3MBTL1 mbt domain with MBK14970 | x-ray diffraction | A | EC7, UNX | — |
| Q9Y468 | AlphaFold monomer V2.0 prediction for LETHAL(3)MALIGNANT brain tumor- like protein 1 (Q9Y468) | predicted | A | — | 7 (best 0.74) |
Ligands
Experiment against prediction
- 2RHY chain A against the predicted model Q9Y468: TM-score 0.99, RMSD 0.47 Å
- 2RHY chain A against the predicted model Q9Y468: TM-score 0.99, RMSD 0.47 Å
- 2RI3 chain A against the predicted model Q9Y468: TM-score 0.99, RMSD 0.49 Å
- 2RI3 chain A against the predicted model Q9Y468: TM-score 0.99, RMSD 0.49 Å
- 2RI2 chain A against the predicted model Q9Y468: TM-score 0.99, RMSD 0.61 Å
- 2RI2 chain A against the predicted model Q9Y468: TM-score 0.99, RMSD 0.61 Å
- 2RI5 chain A against the predicted model Q9Y468: TM-score 0.99, RMSD 0.61 Å
- 2RI5 chain A against the predicted model Q9Y468: TM-score 0.99, RMSD 0.61 Å
- 2RHZ chain A against the predicted model Q9Y468: TM-score 0.99, RMSD 0.61 Å
- 2RHZ chain A against the predicted model Q9Y468: TM-score 0.99, RMSD 0.61 Å
Elsewhere
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