Crystal structure of the 3-mbt repeats from human L3MBTL1 bound to dimethyl-lysine and in chimera with histone H3.3(28-34)

Structure

x-ray diffraction · 1 distinct chain · 21% helix, 30% strand (DSSP).

Ligands and binding sites

• MLY · N-dimethyl-lysine · ligand · chains A
• SO4 · Sulfate ion · ion · chains A
• PG4 · Tetraethylene glycol · additive · chains A
• PEG · Di(hydroxyethyl)ether · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 2 modified (nonstandard).

Compared structures

• 2RHU · Crystal structure of the 3-MBT repeats from human L3MBTL1 bound to dimethyl-lysine and in… · the same entry in another collection · chain A against A, TM-score 1.00
• Q9Y468 · AlphaFold monomer V2.0 prediction for LETHAL(3)MALIGNANT brain tumor- like protein 1… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9Y468
• Elsewhere: RCSB PDB 2RHU · PDBe 2RHU · UniProt Q9Y468