UniProt Q9UQR0
Sex comb on midleg-like protein 2 (Q9UQR0)
Sex comb on midleg-like protein 2 (UniProt Q9UQR0): 10 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 16 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9UQR0
- Protein
- Sex comb on midleg-like protein 2
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 16 · 2 records with a druggable one
Structures
11 records of Q9UQR0 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1OI1 | Crystal Structure of the MBT domains of Human SCML2 | x-ray diffraction | A | — | 1 (best 0.37) |
| 1OI1 | Crystal structure of the mbt domains of human SCML2 | x-ray diffraction | A | — | 1 (best 0.37) |
| 2BIV | Crystal structure of the wild-type MBT domains of Human SCML2 | x-ray diffraction | A, B, C | IOD, NA | 6 (best 0.64) |
| 2BIV | Crystal structure of the wild-type mbt domains of human SCML2 | x-ray diffraction | A, B, C | — | — |
| 2MEM | Solution NMR structure of SLED domain of Scml2 | solution nmr | A | — | 1 (best 0.35) |
| 2MEM | Solution NMR structure of sled domain of SCML2 | solution nmr | A | — | — |
| 2VYT | The MBT repeats of human SCML2 bind to peptides containing mono methylated lysine. | x-ray diffraction | A, B | MLZ | 3 (best 0.37) |
| 2VYT | The mbt repeats of human SCML2 bind to peptides containing mono methylated lysine. | x-ray diffraction | A, B | — | — |
| 4EDU | The MBT repeats of human SCML2 in a complex with histone H2A peptide | x-ray diffraction | A | — | 1 (best 0.43) |
| 4EDU | The mbt repeats of human SCML2 in a complex with histone H2A peptide | x-ray diffraction | A | — | — |
| Q9UQR0 | AlphaFold monomer V2.0 prediction for sex comb on midleg-like protein 2 (Q9UQR0) | predicted | A | — | 3 (best 0.72) |
Ligands
Experiment against prediction
- 2BIV chain A against the predicted model Q9UQR0: TM-score 0.99, RMSD 0.53 Å
- 2BIV chain A against the predicted model Q9UQR0: TM-score 0.99, RMSD 0.53 Å
- 4EDU chain A against the predicted model Q9UQR0: TM-score 0.99, RMSD 0.54 Å
- 4EDU chain A against the predicted model Q9UQR0: TM-score 0.99, RMSD 0.54 Å
- 2BIV chain B against the predicted model Q9UQR0: TM-score 0.99, RMSD 0.70 Å
- 2BIV chain B against the predicted model Q9UQR0: TM-score 0.99, RMSD 0.70 Å
- 2BIV chain C against the predicted model Q9UQR0: TM-score 0.98, RMSD 0.74 Å
- 2BIV chain C against the predicted model Q9UQR0: TM-score 0.98, RMSD 0.74 Å
- 2VYT chain A against the predicted model Q9UQR0: TM-score 0.98, RMSD 0.84 Å
- 1OI1 chain A against the predicted model Q9UQR0: TM-score 0.98, RMSD 0.79 Å
Elsewhere
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