MolNFT v1 · #90251 · protein
The mbt repeats of human SCML2 in a complex with histone H2A peptide
4EDU · Sex comb on midleg-like protein 2: “The mbt repeats of human SCML2 in a complex with histone H2A peptide”. X-ray diffraction, 1 pocket (best druggability 0.43). MolNFT v1 #90251 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 4EDU
- Type
- protein
- Length
- 219 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sex comb on midleg-like protein 2; Histone H2A.J peptide
- UniProt
- Q9UQR0, Q9BTM1
- Pockets
- 1 · best druggability 0.43
Structure
x-ray diffraction · 2 distinct chains · 18% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sex comb on midleg-like protein 2 | protein | 211 | 18% helix, 30% strand | Q9UQR0 |
| T | Histone H2A.J peptide | protein | 8 | 0% helix, 0% strand | Q9BTM1 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 132 | 0.43 | 0.76 | 19 | empty |
Interfaces
1 interface between chains.
- A–T · 318 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 1 modified (methylation).
Compared structures
- 4EDU · The MBT repeats of human SCML2 in a complex with histone H2A peptide · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UQR0 · AlphaFold monomer V2.0 prediction for sex comb on midleg-like protein 2 (Q9UQR0) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q9BTM1 · AlphaFold monomer V2.0 prediction for histone H2A.J (Q9BTM1) · a predicted model of the same protein · chain T against A, TM-score 0.35
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UQR0
- Every structure of UniProt Q9BTM1
- Elsewhere: RCSB PDB 4EDU · PDBe 4EDU · UniProt Q9UQR0 · UniProt Q9BTM1
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