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Ligand · MLZ

MLZ · N-methyl-lysine

MLZ, N-methyl-lysine (C7 H16 N2 O2, 160.2 g/mol), in the MolNFT structures on GenesisL1: bound in 11 records (6 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
MLZ
Formula
C7 H16 N2 O2
Class
ligand
Structures
11
PDB entries
6

Binding sites

MLZ in 11 structures; the first of them:

  • 1P0Y · Crystal structure of the SET domain of LSMT bound to MeLysine and AdoHcy · MLZ C900 · binds SER221, ARG222, ALA223, PHE224, SER225, ARG226, ALA238, ASP239 and 5 more
  • 2H2J · Structure of Rubisco LSMT bound to Sinefungin and Monomethyllysine · MLZ A900 · binds SER221, ARG222, ALA223, PHE224, SER225, ARG226, ALA238, ASP239 and 4 more
  • 2R5A · Crystal Structure of the two MBT repeats from Sex-Comb on Midleg (SCM) in complex with… · MLZ A436 · binds ASP324, ASN327, LEU330, CYS332, PHE348, TRP351, ARG352, PHE355
  • 2RHY · Crystal structure of the 3-MBT repeats from human L3MBTL1 bound to monomethyl-lysine · MLZ A1 · binds ASP355, ASN358, LEU361, CYS363, PHE379, TRP382, TYR386
  • 2VYT · The MBT repeats of human SCML2 bind to peptides containing mono methylated lysine. · MLZ A1244 · binds ASP182, ASN185, LEU188, CYS190, PHE206, TRP209, PHE213
  • 3F70 · Crystal structure of L3MBTL2-H4K20me1 complex · MLZ A20 · binds ASP546, GLU549, LEU552, CYS554, PHE570, TRP573, TYR577, GLU608
  • 1P0Y · Crystal structure of the set domain of lsmt bound to melysine and adohcy · MLZ C900 · binds SER221, ARG222, ALA223, PHE224, SER225, ARG226, ALA238, ASP239 and 5 more
  • 2H2J · Structure of rubisco lsmt bound to sinefungin and monomethyllysine · MLZ A900 · binds SER221, ARG222, ALA223, PHE224, SER225, ARG226, ALA238, ASP239 and 4 more
  • 2R5A · Crystal structure of the two mbt repeats from sex-comb on midleg (scm) in complex with… · MLZ A436 · binds ASP324, ASN327, LEU330, CYS332, PHE348, TRP351, ARG352, PHE355
  • 2RHY · Crystal structure of the 3-mbt repeats from human L3MBTL1 bound to monomethyl-lysine · MLZ A1 · binds ASP355, ASN358, LEU361, CYS363, PHE379, TRP382, TYR386
  • 2VYT · The mbt repeats of human SCML2 bind to peptides containing mono methylated lysine. · MLZ A1244 · binds ASP182, ASN185, LEU188, CYS190, PHE206, TRP209, PHE213

Residues it binds most

TYR 16, PHE 22, ARG 14, SER 12, ASP 22, ALA 12, ILE 12, CYS 10, LEU 10, TRP 10 (residue and the binding sites it lines).

Found with

  • SAH · S-adenosyl-L-homocysteine
  • SFG · Sinefungin
  • PEG · Di(hydroxyethyl)ether
  • PGE · Triethylene glycol

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