UniProt Q9UNA4
DNA polymerase iota (Q9UNA4)
DNA polymerase iota (UniProt Q9UNA4), EC 2.7.7.7: 91 experimental structures on GenesisL1, 5 ligands bound, 17 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q9UNA4
- Protein
- DNA polymerase iota
- EC
- 2.7.7.7
- Experimental structures
- 91
- Predicted models
- 0
- Ligands
- 5
- Pockets
- 17 · 5 records with a druggable one
Structures
91 records of Q9UNA4 in the MolNFT archive: 91 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1T3N | Structure of the catalytic core of DNA polymerase Iota in complex with DNA and dTTP | x-ray diffraction | A, B | — | — |
| 1T3N | Structure of the catalytic core of DNA polymerase iota in complex with DNA and dttp | x-ray diffraction | A, B | — | — |
| 2ALZ | Ternary Complex of hPoli with DNA and dCTP | x-ray diffraction | A | — | — |
| 2ALZ | Ternary complex of hpoli with DNA and dctp | x-ray diffraction | A | — | — |
| 2DPI | Ternary complex of hPoli with DNA and dCTP | x-ray diffraction | A | — | — |
| 2DPI | Ternary complex of hpoli with DNA and dctp | x-ray diffraction | A | — | — |
| 2DPJ | structure of hPoli with DNA and dTTP | x-ray diffraction | A | — | — |
| 2DPJ | Structure of hpoli with DNA and dttp | x-ray diffraction | A | — | — |
| 2FLL | Ternary complex of human DNA polymerase iota with DNA and dTTP | x-ray diffraction | A | — | — |
| 2FLL | Ternary complex of human DNA polymerase iota with DNA and dttp | x-ray diffraction | A | — | — |
| 2FLN | binary complex of catalytic core of human DNA polymerase iota with DNA (template A) | x-ray diffraction | A | — | — |
| 2FLN | Binary complex of catalytic core of human DNA polymerase iota with DNA (template a) | x-ray diffraction | A | — | — |
| 2FLP | Binary complex of the catalytic core of human DNA polymerase iota with DNA (template G) | x-ray diffraction | A | — | — |
| 2FLP | Binary complex of the catalytic core of human DNA polymerase iota with DNA (template G) | x-ray diffraction | A | — | — |
| 2KHU | Solution Structure of the Ubiquitin-Binding Motif of Human Polymerase Iota | solution nmr | A | — | — |
| 2KHU | Solution structure of the ubiquitin-binding motif of human polymerase iota | solution nmr | A | — | — |
| 2KHW | Solution Structure of the human Polymerase iota UBM2-Ubiquitin Complex | solution nmr | A | — | — |
| 2KHW | Solution structure of the human polymerase iota UBM2-ubiquitin complex | solution nmr | A | — | — |
| 2KTF | Solution NMR structure of human polymerase iota UBM2 in complex with ubiquitin | solution nmr | B | — | — |
| 2KTF | Solution NMR structure of human polymerase iota UBM2 in complex with ubiquitin | solution nmr | B | — | — |
| 2L0F | Solution NMR structure of human polymerase iota UBM2 (P692A mutant) in complex with ubiquitin | solution nmr | B | — | — |
| 2L0F | Solution NMR structure of human polymerase iota UBM2 (P692A mutant) in complex with ubiquitin | solution nmr | B | — | — |
| 2L0G | Solution NMR structure of ubiquitin-binding motif (UBM2) of human polymerase iota | solution nmr | A | — | — |
| 2L0G | Solution NMR structure of ubiquitin-binding motif (UBM2) of human polymerase iota | solution nmr | A | — | — |
| 2MBB | Solution Structure of the human Polymerase iota UBM1-Ubiquitin Complex | solution nmr | A | — | — |
| 2MBB | Solution structure of the human polymerase iota UBM1-ubiquitin complex | solution nmr | A | — | — |
| 3EPG | Structure of Human DNA Polymerase Iota complexed with N2-ethylguanine | x-ray diffraction | A | — | — |
| 3EPG | Structure of human DNA polymerase iota complexed with N2-ethylguanine | x-ray diffraction | A | — | — |
| 3EPI | Structure of Human DNA Polymerase Iota complexed with N2-ethylguanine and incoming TTP | x-ray diffraction | A | — | — |
| 3EPI | Structure of human DNA polymerase iota complexed with N2-ethylguanine and incoming ttp | x-ray diffraction | A | — | — |
| 3G6V | DNA synthesis across an abasic lesion by human DNA polymerase-iota | x-ray diffraction | A | — | — |
| 3G6V | DNA synthesis across an abasic lesion by human DNA polymerase-iota | x-ray diffraction | A | — | — |
| 3G6X | Ternary complex of DNA Polymerase iota:DNA:dGTP with an abasic site at the templating position | x-ray diffraction | A | — | — |
| 3G6X | Ternary complex of DNA polymerase IOTA:DNA:DGTP with an abasic site at the templating position | x-ray diffraction | A | — | — |
| 3G6Y | Ternary complex of DNA Polymerase iota:DNA:dTTP with an abasic site at the templating position | x-ray diffraction | A | — | — |
| 3G6Y | Ternary complex of DNA polymerase IOTA:DNA:DTTP with an abasic site at the templating position | x-ray diffraction | A | — | — |
| 3GV5 | Human DNA polymerase iota in complex with T template DNA and incoming ddADP | x-ray diffraction | B, D | — | — |
| 3GV5 | Human DNA polymerase iota in complex with T template DNA and incoming ddadp | x-ray diffraction | B, D | — | — |
| 3GV7 | Human DNA polymerase iota in complex with T template DNA and incoming dTTP | x-ray diffraction | B | — | — |
| 3GV7 | Human DNA polymerase iota in complex with T template DNA and incoming dttp | x-ray diffraction | B | — | — |
| 3GV8 | Human DNA polymerase iota in complex with T template DNA and incoming dGTP | x-ray diffraction | B | — | — |
| 3GV8 | Human DNA polymerase iota in complex with T template DNA and incoming dgtp | x-ray diffraction | B | — | — |
| 3H40 | Binary complex of human DNA polymerase iota with template U/T | x-ray diffraction | A | — | — |
| 3H40 | Binary complex of human DNA polymerase iota with template U/T | x-ray diffraction | A | — | — |
| 3H4B | Ternary complex of human DNA polymerase iota with template U/T and incoming dATP | x-ray diffraction | A | — | — |
| 3H4B | Ternary complex of human DNA polymerase iota with template U/T and incoming datp | x-ray diffraction | A | — | — |
| 3H4D | Ternary complex of human DNA polymerase iota with template U/T and incoming dGTP | x-ray diffraction | A | — | — |
| 3H4D | Ternary complex of human DNA polymerase iota with template U/T and incoming dgtp | x-ray diffraction | A | — | — |
| 3NGD | Structural Basis for Proficient Incorporation of dTTP Opposite O6-methylguanine by Human DNA… | x-ray diffraction | A | — | — |
| 3NGD | Structural basis for proficient incorporation of dttp opposite O6- methylguanine by human DNA… | x-ray diffraction | A | — | — |
| 3OSN | Structural Basis for Proficient Incorporation of dTTP Opposite O6-Methylguanine by Human DNA… | x-ray diffraction | A | — | — |
| 3OSN | Structural basis for proficient incorporation of dttp opposite O6- methylguanine by human DNA… | x-ray diffraction | A | — | — |
| 3Q8P | Human DNA polymerase iota incorporating dCTP opposite 8-oxo-guanine | x-ray diffraction | B | — | — |
| 3Q8P | Human DNA polymerase iota incorporating dctp opposite 8-oxo-guanine | x-ray diffraction | B | — | — |
| 3Q8Q | Human DNA polymerase iota incorporating dATP opposite 8-oxo-guanine | x-ray diffraction | B | — | — |
| 3Q8Q | Human DNA polymerase iota incorporating datp opposite 8-oxo-guanine | x-ray diffraction | B | — | — |
| 3Q8R | Human DNA polymerase iota incorporating dGTP opposite 8-oxo-guanine | x-ray diffraction | B | — | — |
| 3Q8R | Human DNA polymerase iota incorporating dgtp opposite 8-oxo-guanine | x-ray diffraction | B | — | — |
| 3Q8S | Human DNA polymerase iota incorporating dTTP opposite 8-oxo-guanine | x-ray diffraction | B | — | — |
| 3Q8S | Human DNA polymerase iota incorporating dttp opposite 8-oxo-guanine | x-ray diffraction | B | — | — |
31 records more on the page itself.
Ligands
Experiment against prediction
- 2KHU chain A against the predicted model P19909: TM-score 0.51, RMSD 2.61 Å
- 2KHU chain A against the predicted model P19909: TM-score 0.51, RMSD 2.61 Å
- 2KHW chain A against the predicted model P19909: TM-score 0.50, RMSD 2.84 Å
- 2KHW chain A against the predicted model P19909: TM-score 0.50, RMSD 2.84 Å
Elsewhere
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