UniProt Q9UJX6
Anaphase-promoting complex subunit 2 (Q9UJX6)
Anaphase-promoting complex subunit 2 (UniProt Q9UJX6): 37 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 24 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9UJX6
- Protein
- Anaphase-promoting complex subunit 2
- Experimental structures
- 37
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 24 · 12 records with a druggable one
Structures
38 records of Q9UJX6 in the MolNFT archive: 37 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4UI9 | Atomic structure of the human Anaphase-Promoting Complex | electron microscopy | N | — | 2 (best 0.82) |
| 4UI9 | Atomic structure of the human anaphase-promoting complex | electron microscopy | N | — | — |
| 4YII | Structure of an APC2-UBCH10 complex reveals distinctive cullin-RING ligase mechanism for… | x-ray diffraction | A | — | — |
| 4YII | Structure of an APC2-UBCH10 complex reveals distinctive cullin-ring ligase mechanism for… | x-ray diffraction | A | — | — |
| 5G04 | Structure of the human APC-Cdc20-Hsl1 complex | electron microscopy | N | — | — |
| 5G04 | Structure of the human apc-CDC20-HSL1 complex | electron microscopy | N | — | — |
| 5G05 | Cryo-EM structure of combined apo phosphorylated APC | electron microscopy | N | — | — |
| 5G05 | Cryo-EM structure of combined apo phosphorylated apc | electron microscopy | N | — | — |
| 5KHR | Model of human Anaphase-promoting complex/Cyclosome complex (APC15 deletion mutant) in complex with… | electron microscopy | N | — | — |
| 5KHR | Model of human anaphase-promoting COMPLEX/CYCLOSOME complex (APC15 deletion mutant) in complex with… | electron microscopy | N | — | — |
| 5KHU | Model of human Anaphase-promoting complex/Cyclosome (APC15 deletion mutant), in complex with the… | electron microscopy | N | — | — |
| 5KHU | Model of human anaphase-promoting COMPLEX/CYCLOSOME (APC15 deletion mutant), in complex with the… | electron microscopy | N | — | — |
| 5L9T | Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with E2 UBE2S poised for… | electron microscopy | N | — | — |
| 5L9T | Model of human anaphase-promoting COMPLEX/CYCLOSOME (APC/C-CDH1) with E2 UBE2S poised for… | electron microscopy | N | — | — |
| 5L9U | Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with a cross linked Ubiquitin… | electron microscopy | N | — | — |
| 5L9U | Model of human anaphase-promoting COMPLEX/CYCLOSOME (APC/C-CDH1) with a cross linked ubiquitin… | electron microscopy | N | — | — |
| 5LCW | Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Mitotic… | electron microscopy | N | — | 2 (best 0.82) |
| 5LCW | Cryo-EM structure of the anaphase-promoting COMPLEX/CYCLOSOME, in complex with the mitotic… | electron microscopy | N | — | — |
| 6NXK | Ubiquitin binding variants | x-ray diffraction | C, D | — | 3 (best 0.51) |
| 6NXK | Ubiquitin binding variants | x-ray diffraction | C, D | — | — |
| 6OB1 | Structure of WHB in complex with Ubiquitin Variant | solution nmr | C | — | 3 (best 0.45) |
| 6OB1 | Structure of whb in complex with ubiquitin variant | solution nmr | C | — | — |
| 6Q6G | Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D1 box class | electron microscopy | N | — | 2 (best 0.81) |
| 6Q6G | Cryo-EM structure of the APC/C-CDC20-CDK2-CYCLINA2-CKS2 complex, the D1 box class | electron microscopy | N | — | — |
| 6Q6H | Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D2 box class | electron microscopy | N | — | 2 (best 0.80) |
| 6Q6H | Cryo-EM structure of the APC/C-CDC20-CDK2-CYCLINA2-CKS2 complex, the D2 box class | electron microscopy | N | — | — |
| 6TLJ | Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Mitotic… | electron microscopy | N | — | 2 (best 0.80) |
| 6TLJ | Cryo-EM structure of the anaphase-promoting COMPLEX/CYCLOSOME, in complex with the mitotic… | electron microscopy | N | — | — |
| 6TM5 | Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Nek2A substrate… | electron microscopy | N | — | 2 (best 0.83) |
| 6TM5 | Cryo-EM structure of the anaphase-promoting COMPLEX/CYCLOSOME, in complex with the NEK2A substrate… | electron microscopy | N | — | — |
| 6TNT | SUMOylated apoAPC/C with repositioned APC2 WHB domain | electron microscopy | N | — | 2 (best 0.81) |
| 6TNT | Sumoylated APOAPC/C with repositioned APC2 whb domain | electron microscopy | N | — | — |
| 7QE7 | High-resolution structure of the anaphase-promoting COMPLEX/CYCLOSOME (APC/C) bound to co-activator… | electron microscopy | N | ZN | — |
| 8PKP | Cryo-EM structure of the apo Anaphase-promoting complex/cyclosome (APC/C) at 3.2 Angstrom resolution | electron microscopy | N | ZN | 1 (best 0.80) |
| 8TAR | APC/C-CDH1-UBE2C-Ubiquitin-CyclinB-NTD | electron microscopy | N | ZN | 1 (best 0.69) |
| 8TAU | APC/C-CDH1-UBE2C-UBE2S-Ubiquitin-CyclinB | electron microscopy | N | ZN | 1 (best 0.70) |
| 9GAW | High-resolution structure of the Anaphase-promoting complex/cyclosome (APC/C) bound to co-activator… | electron microscopy | N | ZN | 1 (best 0.79) |
| Q9UJX6 | AlphaFold monomer V2.0 prediction for anaphase-promoting complex subunit 2 (Q9UJX6) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 5 records
Experiment against prediction
- 4YII chain A against the predicted model Q9UJX6: TM-score 0.91, RMSD 1.21 Å
- 4YII chain A against the predicted model Q9UJX6: TM-score 0.91, RMSD 1.21 Å
- 6NXK chain D against the predicted model Q9UJX6: TM-score 0.86, RMSD 1.52 Å
- 6NXK chain D against the predicted model Q9UJX6: TM-score 0.86, RMSD 1.52 Å
- 6NXK chain C against the predicted model Q9UJX6: TM-score 0.84, RMSD 1.64 Å
- 6NXK chain C against the predicted model Q9UJX6: TM-score 0.84, RMSD 1.64 Å
- 5L9U chain N against the predicted model Q9UJX6: TM-score 0.84, RMSD 3.97 Å
- 5L9U chain N against the predicted model Q9UJX6: TM-score 0.84, RMSD 3.97 Å
- 6Q6H chain N against the predicted model Q9UJX6: TM-score 0.84, RMSD 4.25 Å
- 6Q6H chain N against the predicted model Q9UJX6: TM-score 0.84, RMSD 4.25 Å
Elsewhere
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