UniProt Q9UHB7
AF4/FMR2 family member 4 (Q9UHB7)
AF4/FMR2 family member 4 (UniProt Q9UHB7): 15 experimental structures and 1 predicted model on GenesisL1, 3 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9UHB7
- Protein
- AF4/FMR2 family member 4
- Experimental structures
- 15
- Predicted models
- 1
- Pockets
- 3 · 0 records with a druggable one
Structures
16 records of Q9UHB7 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4IMY | The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat | x-ray diffraction | G, H, I | — | — |
| 4IMY | The AFF4 scaffold binds human P-tefb adjacent to HIV tat | x-ray diffraction | G, H, I | — | — |
| 4OGR | crystal structure of P-TEFb complex with AFF4 and Tat | x-ray diffraction | C, G, L | — | — |
| 4OGR | Crystal structure of P-tefb complex with AFF4 and tat | x-ray diffraction | C, G, L | — | — |
| 4OR5 | Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4 | x-ray diffraction | E, J | — | — |
| 4OR5 | Crystal structure of HIV-1 tat complexed with human P-tefb and AFF4 | x-ray diffraction | E, J | — | — |
| 5JW9 | The crystal structure of ELL2 oclludin domain and AFF4 peptide | x-ray diffraction | A | — | — |
| 5L1Z | TAR complex with HIV-1 Tat-AFF4-P-TEFb | x-ray diffraction | C | — | 2 (best 0.49) |
| 5L1Z | Tar complex with HIV-1 tat-AFF4-P-tefb | x-ray diffraction | C | — | — |
| 6CYT | HIV-1 tar loop in complex with TAT:AFF4:P-tefb | x-ray diffraction | C | — | — |
| 6K7P | Crystal structure of human AFF4-THD domain | x-ray diffraction | A | — | 1 (best 0.43) |
| 6K7P | Crystal structure of human AFF4-thd domain | x-ray diffraction | A | — | — |
| 6KN5 | Crystal structure of AFF4 C-terminal domain | x-ray diffraction | A | — | — |
| 6KN5 | Crystal structure of AFF4 C-terminal domain | x-ray diffraction | A | — | — |
| 6R80 | Structure of AFF4 C-terminal homology domain | x-ray diffraction | A | — | — |
| Q9UHB7 | AlphaFold monomer V2.0 prediction for AF4/FMR2 family member 4 (Q9UHB7) | predicted | A | — | — |
Experiment against prediction
- 6R80 chain A against the predicted model Q9UHB7: TM-score 0.99, RMSD 0.45 Å
- 6K7P chain A against the predicted model Q9UHB7: TM-score 0.99, RMSD 0.48 Å
- 6K7P chain A against the predicted model Q9UHB7: TM-score 0.99, RMSD 0.48 Å
- 6KN5 chain A against the predicted model Q9UHB7: TM-score 0.96, RMSD 1.45 Å
- 6KN5 chain A against the predicted model Q9UHB7: TM-score 0.96, RMSD 1.45 Å
- 4IMY chain G against the predicted model Q9UHB7: TM-score 0.54, RMSD 2.45 Å
- 4IMY chain G against the predicted model Q9UHB7: TM-score 0.54, RMSD 2.45 Å
- 4IMY chain I against the predicted model Q9UHB7: TM-score 0.54, RMSD 2.46 Å
- 4IMY chain I against the predicted model Q9UHB7: TM-score 0.54, RMSD 2.46 Å
- 6CYT chain C against the predicted model Q9UHB7: TM-score 0.54, RMSD 2.05 Å
Elsewhere
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