UniProt Q9UBQ0
Vacuolar protein sorting-associated protein 29 (Q9UBQ0)
Vacuolar protein sorting-associated protein 29 (UniProt Q9UBQ0): 30 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 99 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q9UBQ0
- Protein
- Vacuolar protein sorting-associated protein 29
- Experimental structures
- 30
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 99 · 12 records with a druggable one
Structures
31 records of Q9UBQ0 in the MolNFT archive: 30 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1W24 | Crystal Structure Of human Vps29 | x-ray diffraction | A | — | — |
| 1W24 | Crystal structure of human VPS29 | x-ray diffraction | A | — | — |
| 2R17 | Functional architecture of the retromer cargo-recognition complex | x-ray diffraction | A, B | — | — |
| 2R17 | Functional architecture of the retromer cargo-recognition complex | x-ray diffraction | A, B | — | — |
| 5GTU | Structural and mechanistic insights into regulation of the retromer coat by TBC1d5 | x-ray diffraction | A | — | — |
| 5GTU | Structural and mechanistic insights into regulation of the retromer coat by TBC1D5 | x-ray diffraction | A | — | — |
| 5OSH | Structure of retromer VPS29-VPS35C subunits complexed with RidL N-terminal domain (1-236) | x-ray diffraction | A, D, G, J | — | 15 (best 0.78) |
| 5OSH | Structure of retromer VPS29-VPS35C subunits complexed with ridl N- terminal domain (1-236) | x-ray diffraction | A, D, G, J | — | — |
| 5OSI | Structure of retromer VPS29-VPS35C subunits complexed with ridl harpin loop (163-176) | x-ray diffraction | A, D, G, J | — | — |
| 5WYH | Crystal structure of RIDL(1-200) complexed with VPS29 | x-ray diffraction | A, C | — | — |
| 6XS5 | Crystal structure of human Vps29 complexed with RaPID-derived cyclic peptide RT-D1 | x-ray diffraction | A | — | 2 (best 0.46) |
| 6XS5 | Crystal structure of human VPS29 complexed with rapid-derived cyclic peptide rt-D1 | x-ray diffraction | A | — | — |
| 6XS7 | Crystal structure of human Vps29 complexed with RaPID-derived cyclic peptide RT-D2 | x-ray diffraction | A | — | 1 (best 0.47) |
| 6XS7 | Crystal structure of human VPS29 complexed with rapid-derived cyclic peptide rt-D2 | x-ray diffraction | A | 48V | — |
| 6XS9 | Crystal structure of human Vps29 complexed with RaPID-derived cyclic peptide RT-L1 | x-ray diffraction | A, B | O4B | 4 (best 0.73) |
| 6XS9 | Crystal structure of human VPS29 complexed with rapid-derived cyclic peptide rt-L1 | x-ray diffraction | A, B | 48V, O4B | — |
| 6XSA | Crystal structure of human Vps29 complexed with RaPID-derived cyclic peptide RT-L2 | x-ray diffraction | A | SO4 | — |
| 6XSA | Crystal structure of human VPS29 complexed with rapid-derived cyclic peptide rt-L2 | x-ray diffraction | A | SO4 | — |
| 7BLN | VPS35/VPS29 arch of metazoan membrane-assembled retromer:SNX3 complex modelled with human proteins | electron microscopy | B, D | — | 5 (best 0.87) |
| 7BLN | VPS35/VPS29 arch of metazoan membrane-assembled RETROMER:SNX3 complex modelled with human proteins | electron microscopy | B, D | — | — |
| 8ESE | Crystal structure of human Vps29 bound to a peptide from Vps35L | x-ray diffraction | Z | — | — |
| 8P0V | Structure of the human Commander complex coiled coils, DENND10 and partial Retriever subcomplex | electron microscopy | N | — | 7 (best 0.77) |
| 8P0X | Structure of the human Commander complex Retriever Subcomplex | electron microscopy | N | — | 6 (best 0.74) |
| 8R02 | Crystal structure of the retromer complex VPS29/VPS35 with the ligand bis-1,3-phenyl… | x-ray diffraction | A, B | XFZ | 11 (best 0.76) |
| 8R0J | Crystal structure of the retromer complex VPS29/VPS35 with the ligand bis-1,3-phenyl… | x-ray diffraction | A, B | — | 10 (best 0.77) |
| 8RKS | Structure of VPS29-VPS35 bound to the LFa motif R21 of Fam21. | x-ray diffraction | A, C, E, G | — | 18 (best 0.74) |
| 8SYM | Human VPS29/VPS35L Complex (Locally refined map) | electron microscopy | B | — | 5 (best 0.75) |
| 8SYN | Human VPS35L/VPS29/VPS26C Complex | electron microscopy | B | — | 7 (best 0.75) |
| 8SYO | Human Retriever VPS35L/VPS29/VPS26C Complex (Composite Map) | electron microscopy | B | — | 7 (best 0.75) |
| 9AU7 | Human Retriever VPS35L/VPS29/VPS26C complex bound to SNX17 peptide (Composite Map) | electron microscopy | B | — | 1 (best 0.74) |
| Q9UBQ0 | AlphaFold monomer V2.0 prediction for vacuolar protein sorting- associated protein 29 (Q9UBQ0) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5GTU chain A against the predicted model Q9UBQ0: TM-score 0.98, RMSD 0.25 Å
- 5GTU chain A against the predicted model Q9UBQ0: TM-score 0.98, RMSD 0.25 Å
- 5WYH chain A against the predicted model Q9UBQ0: TM-score 0.98, RMSD 0.44 Å
- 6XSA chain A against the predicted model Q9UBQ0: TM-score 0.99, RMSD 0.50 Å
- 6XSA chain A against the predicted model Q9UBQ0: TM-score 0.99, RMSD 0.50 Å
- 8ESE chain Z against the predicted model Q9UBQ0: TM-score 0.99, RMSD 0.49 Å
- 6XS7 chain A against the predicted model Q9UBQ0: TM-score 0.98, RMSD 0.51 Å
- 6XS7 chain A against the predicted model Q9UBQ0: TM-score 0.98, RMSD 0.51 Å
- 6XS9 chain A against the predicted model Q9UBQ0: TM-score 0.98, RMSD 0.50 Å
- 6XS9 chain A against the predicted model Q9UBQ0: TM-score 0.98, RMSD 0.50 Å
Elsewhere
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