UniProt Q9NR97
Toll-like receptor 8 (Q9NR97)
Toll-like receptor 8 (UniProt Q9NR97): 59 experimental structures on GenesisL1, 20 ligands bound, 31 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q9NR97
- Protein
- Toll-like receptor 8
- Experimental structures
- 59
- Predicted models
- 0
- Ligands
- 20
- Pockets
- 31 · 4 records with a druggable one
Structures
59 records of Q9NR97 in the MolNFT archive: 59 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3W3G | Crystal structure of human TLR8 (unliganded form) | x-ray diffraction | A, B | — | — |
| 3W3G | Crystal structure of human TLR8 (unliganded form) | x-ray diffraction | A, B | — | — |
| 3W3J | Crystal structure of human TLR8 in complex with CL097 | x-ray diffraction | A, B | — | — |
| 3W3J | Crystal structure of human TLR8 in complex with CL097 | x-ray diffraction | A, B | — | — |
| 3W3K | Crystal structure of human TLR8 in complex with CL075 | x-ray diffraction | A, B | — | — |
| 3W3K | Crystal structure of human TLR8 in complex with CL075 | x-ray diffraction | A, B | — | — |
| 3W3L | Crystal structure of human TLR8 in complex with Resiquimod (R848) crystal form 1 | x-ray diffraction | A, B, C, D | — | — |
| 3W3L | Crystal structure of human TLR8 in complex with resiquimod (R848) crystal form 1 | x-ray diffraction | A, B, C, D | — | — |
| 3W3M | Crystal structure of human TLR8 in complex with Resiquimod (R848) crystal form 2 | x-ray diffraction | A | — | — |
| 3W3M | Crystal structure of human TLR8 in complex with resiquimod (R848) crystal form 2 | x-ray diffraction | A | — | — |
| 3W3N | Crystal structure of human TLR8 in complex with Resiquimod (R848) crystal form 3 | x-ray diffraction | A, B | — | — |
| 3W3N | Crystal structure of human TLR8 in complex with resiquimod (R848) crystal form 3 | x-ray diffraction | A, B | — | — |
| 3WN4 | Crystal structure of human TLR8 in complex with DS-877 | x-ray diffraction | A | — | — |
| 3WN4 | Crystal structure of human TLR8 in complex with ds-877 | x-ray diffraction | A | — | — |
| 4QBZ | Crystal structure of human TLR8 in complex with DS-802 | x-ray diffraction | A, B | — | — |
| 4QBZ | Crystal structure of human TLR8 in complex with ds-802 | x-ray diffraction | A, B | — | — |
| 4QC0 | Crystal structure of human TLR8 in complex with XG-1-236 | x-ray diffraction | A, B | — | — |
| 4QC0 | Crystal structure of human TLR8 in complex with xg-1-236 | x-ray diffraction | A, B | — | — |
| 4R07 | Crystal structure of human TLR8 in complex with ORN06 | x-ray diffraction | A, B, C, D | — | — |
| 4R07 | Crystal structure of human TLR8 in complex with ORN06 | x-ray diffraction | A, B, C, D | — | — |
| 4R08 | Crystal structure of human TLR8 in complex with ssRNA40 | x-ray diffraction | A, B, C, D | — | — |
| 4R08 | Crystal structure of human TLR8 in complex with SSRNA40 | x-ray diffraction | A, B, C, D | — | — |
| 4R09 | Crystal structure of human TLR8 in complex with ORN06S | x-ray diffraction | A, B, C, D | — | — |
| 4R09 | Crystal structure of human TLR8 in complex with ORN06S | x-ray diffraction | A, B, C, D | — | — |
| 4R0A | Crystal structure of human TLR8 in complex with uridine mononucleoside | x-ray diffraction | A | — | — |
| 4R0A | Crystal structure of human TLR8 in complex with uridine mononucleoside | x-ray diffraction | A | — | — |
| 4R6A | Crystal structure of human TLR8 in complex with Hybrid-2 | x-ray diffraction | A, B | — | — |
| 4R6A | Crystal structure of human TLR8 in complex with hybrid-2 | x-ray diffraction | A, B | — | — |
| 5AWA | Crystal structure of human TLR8 in complex with MB-568 | x-ray diffraction | A | — | — |
| 5AWA | Crystal structure of human TLR8 in complex with mb-568 | x-ray diffraction | A | — | — |
| 5AWB | Crystal structure of human TLR8 in complex with N1-3-aminomethylbenzyl (meta-amine) | x-ray diffraction | A | — | — |
| 5AWB | Crystal structure of human TLR8 in complex with N1-3-aminomethylbenzyl (meta-amine) | x-ray diffraction | A | — | — |
| 5AWC | Crystal structure of human TLR8 in complex with MB-564 | x-ray diffraction | A, B, C, D | — | — |
| 5AWC | Crystal structure of human TLR8 in complex with mb-564 | x-ray diffraction | A, B, C, D | — | — |
| 5AWD | Crystal structure of human TLR8 in complex with N1-4-aminomethylbenzyl (IMDQ) | x-ray diffraction | A | NAG, BMA, MAN, IDQ | 3 (best 0.68) |
| 5AWD | Crystal structure of human TLR8 in complex with N1-4-aminomethylbenzyl (imdq) | x-ray diffraction | A | — | — |
| 5AZ5 | Crystal structure of human TLR8 in complex with MB-343 | x-ray diffraction | A, B, C, D | — | — |
| 5AZ5 | Crystal structure of human TLR8 in complex with mb-343 | x-ray diffraction | A, B, C, D | — | — |
| 5HDH | Crystal structure of human TLR8 with an uncleaved Z-loop | x-ray diffraction | A | NAG, BMA, SO4 | 5 (best 0.69) |
| 5HDH | Crystal structure of human TLR8 with an uncleaved Z-loop | x-ray diffraction | A | — | — |
| 5WYX | Crystal structure of human TLR8 in complex with CU-CPT8m | x-ray diffraction | A, B | NAG, BMA, MAN, CU8 | — |
| 5WYX | Crystal structure of human TLR8 in complex with cu-CPT8M | x-ray diffraction | A, B | NAG, BMA, MAN, CU8 | — |
| 5WYZ | Crystal structure of human TLR8 in complex with cu-CPT9B | x-ray diffraction | A, B | NAG, BMA, MAN, 7VF | — |
| 5Z14 | Crystal structure of human TLR8 in complex with cu-CPT9A | x-ray diffraction | A, B | NAG, BMA, 7VC | — |
| 5Z15 | Crystal structure of human TLR8 in complex with CU-CPT9c | x-ray diffraction | A, B | NAG, BMA, 7VL | — |
| 5Z15 | Crystal structure of human TLR8 in complex with cu-CPT9C | x-ray diffraction | A, B | NAG, BMA, 7VL | — |
| 6KYA | Crystal structure of human TLR8 in complex TH1027 | x-ray diffraction | A, B | NAG, MAN, BMA, DY3 | — |
| 6TY5 | Crystal structure of human TLR8 in complex with Compound 11 | x-ray diffraction | A, B | NAG, MAN, BMA, O0W | 10 (best 0.75) |
| 6TY5 | Crystal structure of human TLR8 in complex with compound 11 | x-ray diffraction | A, B | NAG, MAN, BMA, O0W | — |
| 6V9U | Crystal structure of human TLR8 ectodomain bound to small molecule antagonist 14C | x-ray diffraction | A, B | NAG, BMA, MAN, QSM | — |
| 6WML | Human TLR8 bound to the potent agonist, gs-9688 (selgantolimod) | x-ray diffraction | A, B, C, D | NAG, BMA, MAN, U57 | — |
| 6ZJZ | Discovery of M5049: a novel selective TLR7/8 inhibitor for treatment of autoimmunity | x-ray diffraction | A, B | NAG, MAN, BMA, QLH | — |
| 7CRF | Crystal structure of human TLR8 in complex with cu-CPD107 | x-ray diffraction | A, B | NAG, MAN, BMA, GD0 | — |
| 7R52 | Crystal structure of human TLR8 in complex with compound 2 | x-ray diffraction | A, B | NAG, MAN, BMA, I6A | — |
| 7R53 | Crystal structure of human TLR8 in complex with compound 15 | x-ray diffraction | A, B | NAG, MAN, BMA, I5N | — |
| 7R54 | Crystal structure of human TLR8 in complex with compound 4 | x-ray diffraction | A, B | NAG, MAN, BMA, I5B | — |
| 7RC9 | Crystal structure of human TLR8 ectodomain bound to small molecule antagonist 21 | x-ray diffraction | A, B | NAG, BMA, RQY | — |
| 8PFI | Crystal structure of human TLR8 in complex with compound 34 | x-ray diffraction | A, B | NAG, BMA, MAN, YHG | 13 (best 0.72) |
| Q9NR97 | AlphaFold monomer V2.0 prediction for toll-like receptor 8 (Q9NR97) | — | — | — |
Ligands
- BMA · beta-D-mannopyranose · in 20 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 20 records
- MAN · alpha-D-mannopyranose · in 15 records
- 7VL · 4-(7-chloranylquinolin-4-yl)-2-methyl-phenol · in 2 records
- CU8 · 7-(3-methylphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide · in 2 records
- O0W · 5-methyl-7-(7-methyl-2-piperidin-4-yl-indazol-5-yl) furo[3,2-c]pyridin-4-one · in 2 records
- 7VC · 4-(7-methoxyquinolin-4-yl)-2-methyl-phenol · in 1 record
- 7VF · 4-(3-methyl-4-oxidanyl-phenyl)quinolin-7-ol · in 1 record
- DY3 · 3-[5-methylsulfanyl-4-(3,4,5-trimethylphenyl)-1,2,4-triazol-3-yl]propan-1-ol · in 1 record
- GD0 · 1-[2-(ethoxymethyl)-4-iodanyl-5-phenyl-imidazol-1-yl]-2-methyl-propan-2-ol · in 1 record
- I5B · (5-methoxy-6-pyridin-4-yl-1~{H}-indazol-3-yl)-(4-methylpiperazin-1-yl)methanone · in 1 record
- I5N · 5-cyclopropyl-6-(2,6-dimethylpyridin-4-yl)-~{N}-[(3~{R},4~{R})-3-fluoranylpiperidin-4-yl]-1~{H}-indazol-3-amine · in 1 record
- I6A · 5-methoxy-6-pyridin-4-yl-1~{H}-indole · in 1 record
- IDQ · 1-[[4-(aminomethyl)phenyl]methyl]-2-butyl-imidazo[4,5-c]quinolin-4-amine · in 1 record
- QLH · 5-[(3~{R},5~{S})-3-azanyl-5-(trifluoromethyl)piperidin-1-yl]quinoline-8-carbonitrile · in 1 record
- QSM · 2-(3,4-dimethoxyphenyl)-5-(piperidin-4-yl)-3-(propan-2-yl)-1H-indole · in 1 record
- RQY · 2-(2,6-dimethylpyridin-4-yl)-5-(piperidin-4-yl)-3-(propan-2-yl)-1H-indole · in 1 record
- SO4 · Sulfate ion · in 1 record
- U57 · (2R)-2-[(2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl) amino]-2-methylhexan-1-ol · in 1 record
- YHG · (3~{S})-~{N}-[4-[[5-(1,6-dimethylpyrazolo[3,4-b]pyridin-4-yl)-3-methyl-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-1-yl]methyl]-1-bicyclo[2.2.2]octanyl]morpholine-3-carboxamide · in 1 record
Elsewhere
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