UniProt Q9NP87
DNA-directed DNA/RNA polymerase mu (Q9NP87)
DNA-directed DNA/RNA polymerase mu (UniProt Q9NP87), EC 2.7.7.7: 218 experimental structures and 1 predicted model on GenesisL1, 31 ligands bound, 147 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9NP87
- Protein
- DNA-directed DNA/RNA polymerase mu
- EC
- 2.7.7.7
- Experimental structures
- 218
- Predicted models
- 1
- Ligands
- 31
- Pockets
- 147 · 67 records with a druggable one
Structures
219 records of Q9NP87 in the MolNFT archive: 218 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2DUN | Solution structure of BRCT domain of DNA polymerase mu | solution nmr | A | — | — |
| 2DUN | Solution structure of brct domain of DNA polymerase mu | solution nmr | A | — | — |
| 2HTF | The solution structure of the BRCT domain from human polymerase reveals homology with the TdT BRCT… | solution nmr | A | — | — |
| 2HTF | The solution structure of the brct domain from human polymerase reveals homology with the tdt brct… | solution nmr | A | — | — |
| 4LZD | Human DNA polymerase mu- Apoenzyme | x-ray diffraction | A | — | — |
| 4LZD | Human DNA polymerase mu- apoenzyme | x-ray diffraction | A | — | — |
| 4LZG | Binary complex of human DNA Polymerase Mu with DNA | x-ray diffraction | A | — | — |
| 4LZG | Binary complex of human DNA polymerase mu with DNA | x-ray diffraction | A | — | — |
| 4M04 | Human DNA Polymerase Mu ternary complex | x-ray diffraction | A | — | — |
| 4M04 | Human DNA polymerase mu ternary complex | x-ray diffraction | A | — | — |
| 4M0A | Human DNA Polymerase Mu post-catalytic complex | x-ray diffraction | A | — | — |
| 4M0A | Human DNA polymerase mu post-catalytic complex | x-ray diffraction | A | — | — |
| 4YCX | Binary complex of human DNA Polymerase Mu with 2-nt gapped DNA substrate | x-ray diffraction | A | — | — |
| 4YCX | Binary complex of human DNA polymerase mu with 2-nt gapped DNA substrate | x-ray diffraction | A | — | — |
| 4YD1 | Ternary complex of human DNA Polymerase Mu with 2-nt gapped DNA substrate and an incoming… | x-ray diffraction | A | — | — |
| 4YD1 | Ternary complex of human DNA polymerase mu with 2-nt gapped DNA substrate and an incoming… | x-ray diffraction | A | — | — |
| 4YD2 | Nicked complex of human DNA Polymerase Mu with 2-nt gapped DNA substrate | x-ray diffraction | A | — | — |
| 4YD2 | Nicked complex of human DNA polymerase mu with 2-nt gapped DNA substrate | x-ray diffraction | A | — | — |
| 5TWP | Pre-catalytic ternary complex of human Polymerase Mu with incoming nonhydrolyzable UMPNPP | x-ray diffraction | A | 2KH, MG, NA | 3 (best 0.73) |
| 5TWP | Pre-catalytic ternary complex of human polymerase mu with incoming nonhydrolyzable umpnpp | x-ray diffraction | A | 2KH, MG, NA | — |
| 5TWQ | Post-catalytic nicked complex of human Polymerase Mu with newly incorporated UTP | x-ray diffraction | A | MN, MG, NA, CL, PPV | 2 (best 0.72) |
| 5TWQ | Post-catalytic nicked complex of human polymerase mu with newly incorporated UTP | x-ray diffraction | A | MN, MG, NA, CL, PPV | — |
| 5TWR | Pre-catalytic ternary complex of human Polymerase Mu (H329A) mutant with incoming nonhydrolyzable… | x-ray diffraction | A | 2KH, MG, CL, NA | 2 (best 0.73) |
| 5TWR | Pre-catalytic ternary complex of human polymerase mu (H329A) mutant with incoming nonhydrolyzable… | x-ray diffraction | A | 2KH, MG, CL, NA | — |
| 5TWS | Post-catalytic complex of human Polymerase Mu (H329A) with newly incorporated UTP | x-ray diffraction | A | MG, NA, GOA, CL | 2 (best 0.71) |
| 5TWS | Post-catalytic complex of human polymerase mu (H329A) with newly incorporated UTP | x-ray diffraction | A | MG, NA, GOA, CL | — |
| 5TXX | DNA polymerase mu pre-catalytic ground state ternary complex, CA2+ | x-ray diffraction | A | TTP, CA, NA | — |
| 5TXZ | DNA Polymerase Mu Reactant Complex, 100mM Mg2+ (15 min) | x-ray diffraction | A | TTP, MG, CA, NA, PPV | — |
| 5TXZ | DNA polymerase mu reactant complex, 100MM MG2+ (15 min) | x-ray diffraction | A | TTP, MG, CA, NA, PPV | — |
| 5TYB | DNA Polymerase Mu Reactant Complex, 10mM Mg2+ (7.5 min) | x-ray diffraction | A | MG, TTP, NA, CA, PPV | 2 (best 0.73) |
| 5TYB | DNA polymerase mu reactant complex, 10MM MG2+ (7.5 min) | x-ray diffraction | A | MG, TTP, NA, CA, PPV | — |
| 5TYC | DNA Polymerase Mu Reactant Complex, 10mM Mg2+ (15 min) | x-ray diffraction | A | MG, PPV, TTP, NA, CA | — |
| 5TYC | DNA polymerase mu reactant complex, 10MM MG2+ (15 min) | x-ray diffraction | A | MG, PPV, TTP, NA, CA | — |
| 5TYD | DNA Polymerase Mu Reactant Complex, 10 mM Mg2+ (45 min) | x-ray diffraction | A | MG, NA, TTP, PPV | 2 (best 0.72) |
| 5TYD | DNA polymerase mu reactant complex, 10 mm MG2+ (45 min) | x-ray diffraction | A | MG, NA, TTP, PPV | — |
| 5TYE | DNA Polymerase Mu Product Complex, 10 mM Mg2+ (60 min) | x-ray diffraction | A | MG, NA, PPV | 2 (best 0.72) |
| 5TYE | DNA polymerase mu product complex, 10 mm MG2+ (60 min) | x-ray diffraction | A | MG, NA, PPV | — |
| 5TYF | DNA Polymerase Mu Product Complex, 10 mM Mg2+ (270 min) | x-ray diffraction | A | MG, NA, GOA | 2 (best 0.72) |
| 5TYF | DNA polymerase mu product complex, 10 mm MG2+ (270 min) | x-ray diffraction | A | MG, NA, GOA | — |
| 5TYG | DNA polymerase mu product complex, 10 mm MG2+ (960 min) | x-ray diffraction | A | MG, NA, GOA | — |
| 5TYU | DNA Polymerase Mu Reactant Complex, Mn2+ (4 min) | x-ray diffraction | A | TTP, MN, NA, CA, PPV | 2 (best 0.73) |
| 5TYU | DNA polymerase mu reactant complex, MN2+ (4 min) | x-ray diffraction | A | TTP, MN, NA, CA, PPV | — |
| 5TYV | DNA Polymerase Mu Reactant Complex, Mn2+ (7.5 min) | x-ray diffraction | A | TTP, MN, NA, PPV | 2 (best 0.73) |
| 5TYV | DNA polymerase mu reactant complex, MN2+ (7.5 min) | x-ray diffraction | A | TTP, MN, NA, PPV | — |
| 5TYW | DNA polymerase mu reactant complex, MN2+ (10 min) | x-ray diffraction | A | TTP, PPV, MN, NA | — |
| 5TYX | DNA Polymerase Mu Product Complex, Mn2+ (15 min) | x-ray diffraction | A | PPV, MN, NA | 2 (best 0.73) |
| 5TYX | DNA polymerase mu product complex, MN2+ (15 min) | x-ray diffraction | A | PPV, MN, NA | — |
| 5TYY | DNA Polymerase Mu Product Complex, Mn2+ (60 min) | x-ray diffraction | A | MN, NA, PPV | — |
| 5TYY | DNA polymerase mu product complex, MN2+ (60 min) | x-ray diffraction | A | MN, NA, PPV | — |
| 5TYZ | DNA Polymerase Mu Product Complex, Mn2+ (960 min) | x-ray diffraction | A | MN, NA, GOA | 2 (best 0.73) |
| 5TYZ | DNA polymerase mu product complex, MN2+ (960 min) | x-ray diffraction | A | MN, NA, GOA | — |
| 5VZ7 | Pre-catalytic ternary complex of human Polymerase Mu (G433A) mutant with incoming nonhydrolyzable… | x-ray diffraction | A | 2KH, MG, NA, CL | — |
| 5VZ7 | Pre-catalytic ternary complex of human polymerase mu (G433A) mutant with incoming nonhydrolyzable… | x-ray diffraction | A | 2KH, MG, NA, CL | — |
| 5VZ8 | Post-catalytic complex of human Polymerase Mu (G433A) mutant with incoming UTP | x-ray diffraction | A | MG, NA, UTP | 2 (best 0.76) |
| 5VZ8 | Post-catalytic complex of human polymerase mu (G433A) mutant with incoming UTP | x-ray diffraction | A | MG, NA, UTP | — |
| 5VZ9 | Post-catalytic complex of human Polymerase Mu (G433A) mutant with incoming dTTP | x-ray diffraction | A | MG, CL, NA, TTP | 2 (best 0.72) |
| 5VZ9 | Post-catalytic complex of human polymerase mu (G433A) mutant with incoming dttp | x-ray diffraction | A | MG, CL, NA, TTP | — |
| 5VZA | Pre-catalytic ternary complex of human Polymerase Mu (G433S) mutant with incoming nonhydrolyzable… | x-ray diffraction | A | 2KH, MG, NA | 2 (best 0.73) |
| 5VZA | Pre-catalytic ternary complex of human polymerase mu (G433S) mutant with incoming nonhydrolyzable… | x-ray diffraction | A | 2KH, MG, NA | — |
| 5VZB | Post-catalytic complex of human polymerase mu (G433S) mutant with incoming UTP | x-ray diffraction | A | MG, NA, CL, UTP | — |
159 records more on the page itself.
Ligands
- NA · Sodium ion · in 167 records
- MG · Magnesium ion · in 108 records
- CL · Chloride ion · in 80 records
- MN · Manganese (II) ion · in 74 records
- PPV · Pyrophosphate · in 60 records
- GOA · Glycolic acid · in 25 records
- 8DG · 8-oxo-2'-deoxyguanosine-5'-triphosphate · in 24 records
- CA · Calcium ion · in 24 records
- TTP · Thymidine-5'-triphosphate · in 23 records
- SO4 · Sulfate ion · in 19 records
- DGT · 2'-deoxyguanosine-5'-triphosphate · in 16 records
- 2KH · 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine · in 11 records
- 8GT · 8-oxo-guanosine-5'-triphosphate · in 11 records
- K · Potassium ion · in 11 records
- UTP · Uridine 5'-triphosphate · in 8 records
- XG4 · 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine · in 8 records
- ATP · Adenosine-5'-triphosphate · in 6 records
- PO4 · Phosphate ion · in 5 records
- 0KX · 2'-deoxy-5'-O-[(R)-hydroxy{[(r)-hydroxy(phosphonooxy) phosphoryl]amino}phosphoryl]cytidine · in 4 records
- 2TM · 5'-O-[(S)-hydroxy{[(s)-hydroxy(phosphonooxy) phosphoryl]methyl}phosphoryl]cytidine · in 4 records
- DUP · 2'-deoxyuridine 5'-alpha,beta-imido-triphosphate · in 4 records
- CTP · Cytidine-5'-triphosphate · in 3 records
- DCP · 2'-deoxycytidine-5'-triphosphate · in 3 records
- DTP · 2'-deoxyadenosine 5'-triphosphate · in 3 records
- BR · Bromide ion · in 2 records
- CO2 · Carbon dioxide · in 2 records
- DZ4 · 2'-deoxy-5'-O-[(R)-hydroxy{[(r)-hydroxy(phosphonooxy) phosphoryl]amino}phosphoryl]adenosine · in 2 records
- OXD · Oxalic acid · in 2 records
- OXL · Oxalate ion · in 2 records
- GTP · Guanosine-5'-triphosphate · in 1 record
Experiment against prediction
- 4YD2 chain A against the predicted model Q9NP87: TM-score 1.00, RMSD 0.41 Å
- 4YD2 chain A against the predicted model Q9NP87: TM-score 1.00, RMSD 0.41 Å
- 4YCX chain A against the predicted model Q9NP87: TM-score 1.00, RMSD 0.47 Å
- 4YCX chain A against the predicted model Q9NP87: TM-score 1.00, RMSD 0.47 Å
- 5TYX chain A against the predicted model Q9NP87: TM-score 0.99, RMSD 0.49 Å
- 5TYX chain A against the predicted model Q9NP87: TM-score 0.99, RMSD 0.49 Å
- 5TWS chain A against the predicted model Q9NP87: TM-score 0.99, RMSD 0.50 Å
- 5TWS chain A against the predicted model Q9NP87: TM-score 0.99, RMSD 0.50 Å
- 5TYY chain A against the predicted model Q9NP87: TM-score 0.99, RMSD 0.50 Å
- 5TYY chain A against the predicted model Q9NP87: TM-score 0.99, RMSD 0.50 Å
Elsewhere
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