UniProt Q9L1K2
Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase 1 (Q9L1K2)
Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase 1 (UniProt Q9L1K2), EC 2.4.99.16: 37 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 51 pockets. Binding sites, druggability and experiment…
- UniProt
- Q9L1K2
- Protein
- Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase 1
- EC
- 2.4.99.16
- Experimental structures
- 37
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 51 · 4 records with a druggable one
Structures
38 records of Q9L1K2 in the MolNFT archive: 37 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3ZSS | Apo form of GlgE isoform 1 from Streptomyces coelicolor | x-ray diffraction | A, B, C, D | — | — |
| 3ZSS | Apo form of glge isoform 1 from streptomyces coelicolor | x-ray diffraction | A, B, C, D | — | — |
| 3ZST | GlgE isoform 1 from Streptomyces coelicolor with alpha-cyclodextrin bound | x-ray diffraction | A, B | — | — |
| 3ZST | Glge isoform 1 from streptomyces coelicolor with alpha-cyclodextrin bound | x-ray diffraction | A, B | — | — |
| 3ZT5 | GlgE isoform 1 from Streptomyces coelicolor with maltose bound | x-ray diffraction | A, B, C, D | — | — |
| 3ZT5 | Glge isoform 1 from streptomyces coelicolor with maltose bound | x-ray diffraction | A, B, C, D | — | — |
| 3ZT6 | GlgE isoform 1 from Streptomyces coelicolor with alpha-cyclodextrin and maltose bound | x-ray diffraction | A, B, C, D | — | — |
| 3ZT6 | Glge isoform 1 from streptomyces coelicolor with alpha-cyclodextrin and maltose bound | x-ray diffraction | A, B, C, D | — | — |
| 3ZT7 | GlgE isoform 1 from Streptomyces coelicolor with beta-cyclodextrin and maltose bound | x-ray diffraction | A, B, C, D | — | — |
| 3ZT7 | Glge isoform 1 from streptomyces coelicolor with beta-cyclodextrin and maltose bound | x-ray diffraction | A, B, C, D | — | — |
| 4CN1 | GlgE isoform 1 from Streptomyces coelicolor D394A mutant with maltose- 1-phosphate bound | x-ray diffraction | A, B | — | — |
| 4CN1 | Glge isoform 1 from streptomyces coelicolor D394A mutant with maltose- 1-phosphate bound | x-ray diffraction | A, B | — | — |
| 4CN4 | GlgE isoform 1 from Streptomyces coelicolor E423A mutant with 2-deoxy- 2-fluoro-beta-maltosyl… | x-ray diffraction | A, B | — | — |
| 4CN4 | Glge isoform 1 from streptomyces coelicolor E423A mutant with 2-deoxy- 2-fluoro-beta-maltosyl… | x-ray diffraction | A, B | — | — |
| 4CN6 | GlgE isoform 1 from Streptomyces coelicolor E423A mutant with maltose bound | x-ray diffraction | A, B | — | — |
| 4CN6 | Glge isoform 1 from streptomyces coelicolor E423A mutant with maltose bound | x-ray diffraction | A, B | — | — |
| 4U2Y | Sco GlgEI-V279S in Complex with Reaction Intermediate Azasugar | x-ray diffraction | A, B | — | — |
| 4U2Y | Sco glgei-V279S in complex with reaction intermediate azasugar | x-ray diffraction | A, B | — | — |
| 4U2Z | X-ray crystal structure of an Sco GlgEI-V279S/1,2,2-trifluromaltose complex | x-ray diffraction | A, B | — | — |
| 4U2Z | X-ray crystal structure of an sco glgei-V279S/1,2,2-trifluromaltose complex | x-ray diffraction | A, B | — | — |
| 4U31 | Sco GlgEI-V279S in Complex with maltose-C-phosphonate | x-ray diffraction | A, B | — | — |
| 4U31 | Sco glgei-V279S in complex with maltose-C-phosphonate | x-ray diffraction | A, B | — | — |
| 5CVS | Glge isoform 1 from streptomyces coelicolor E423A mutant soaked in maltoheptaose | x-ray diffraction | A, B | — | — |
| 5LGV | GlgE isoform 1 from Streptomyces coelicolor E423A mutant soaked in maltooctaose | x-ray diffraction | A, B | GLC | 12 (best 0.77) |
| 5LGV | Glge isoform 1 from streptomyces coelicolor E423A mutant soaked in maltooctaose | x-ray diffraction | A, B | GLC | — |
| 5LGW | GlgE isoform 1 from Streptomyces coelicolor D394A mutant co-crystallised with maltodextrin | x-ray diffraction | A, B | GLC, BGC | 13 (best 0.77) |
| 5LGW | Glge isoform 1 from streptomyces coelicolor D394A mutant co- crystallised with maltodextrin | x-ray diffraction | A, B | GLC, BGC | — |
| 5VSJ | Sco GlgEI-V279S in complex with a pyrolidene-based ethyl-phosphonate compound | x-ray diffraction | A, B | 9HV | — |
| 5VSJ | Sco glgei-V279S in complex with a pyrolidene-based ethyl-phosphonate compound | x-ray diffraction | A, B | 9HV | — |
| 5VT4 | Sco GlgEI-V279S in complex with a pyrolidene-based methyl-phosphonate compound | x-ray diffraction | A, B, C, D | 9KJ | — |
| 5VT4 | Sco glgei-V279S in complex with a pyrolidene-based methyl-phosphonate compound | x-ray diffraction | A, B, C, D | 9KJ | — |
| 7MEL | Sco GlgEI-V279S in complex with 4-alpha-glucoside of validamine | x-ray diffraction | A, B | Z3D, CL | — |
| 7MEL | Sco glgei-V279S in complex with 4-alpha-glucoside of validamine | x-ray diffraction | A, B | Z3D, CL | — |
| 7MGY | Sco GlgEI-V279S in complex with 4-alpha-glucoside of valienamine | x-ray diffraction | A, B | ZD1 | — |
| 7MGY | Sco glgei-V279S in complex with 4-alpha-glucoside of valienamine | x-ray diffraction | A, B | ZD1 | — |
| 7UVD | Sco GlgEI-V279S in complex with cyclohexyl carbasugar | x-ray diffraction | B, A | RT6 | 13 (best 0.80) |
| 8D6K | Sco GlgEI-V279S in complex with cyclohexyl carbasugar | x-ray diffraction | B, A | RT6 | 13 (best 0.79) |
| Q9L1K2 | AlphaFold monomer V2.0 prediction for alpha-1,4-GLUCAN:MALTOSE-1-phosphate maltosyltransferase 1… | predicted | A | — | — |
Ligands
- GLC · alpha-D-glucopyranose · in 4 records
- 9HV · {2-[(2R,3R,4R,5R)-3-(alpha-D-glucopyranosyloxy)-4-hydroxy-2,5-bis(hydroxymethyl)pyrrolidin-1-yl]ethyl}phosphonic acid · in 2 records
- 9KJ · {[(2R,3R,4R,5R)-3-(alpha-D-glucopyranosyloxy)-4-hydroxy-2,5-bis(hydroxymethyl)pyrrolidin-1-yl]methyl}phosphonic acid · in 2 records
- BGC · beta-D-glucopyranose · in 2 records
- CL · Chloride ion · in 2 records
- RT6 · (1R,4S,5S,6R)-4-(cyclohexylamino)-5,6-dihydroxy-2-(hydroxymethyl)cyclohex-2-en-1-yl alpha-D-glucopyranoside · in 2 records
- Z3D · (1R,2R,3S,4S,6R)-4-amino-2,3-dihydroxy-6-(hydroxymethyl)cyclohexyl alpha-D-glucopyranoside · in 2 records
- ZD1 · (1R,4S,5S,6R)-4-amino-5,6-dihydroxy-2-(hydroxymethyl) cyclohex-2-en-1-yl alpha-D-glucopyranoside · in 2 records
Experiment against prediction
- 4U31 chain B against the predicted model Q9L1K2: TM-score 1.00, RMSD 0.20 Å
- 4U31 chain B against the predicted model Q9L1K2: TM-score 1.00, RMSD 0.20 Å
- 5VSJ chain B against the predicted model Q9L1K2: TM-score 1.00, RMSD 0.22 Å
- 5VSJ chain B against the predicted model Q9L1K2: TM-score 1.00, RMSD 0.22 Å
- 4U2Z chain B against the predicted model Q9L1K2: TM-score 1.00, RMSD 0.27 Å
- 4U2Z chain B against the predicted model Q9L1K2: TM-score 1.00, RMSD 0.27 Å
- 4U2Y chain B against the predicted model Q9L1K2: TM-score 1.00, RMSD 0.31 Å
- 4U2Y chain B against the predicted model Q9L1K2: TM-score 1.00, RMSD 0.31 Å
- 5VT4 chain A against the predicted model Q9L1K2: TM-score 1.00, RMSD 0.37 Å
- 5VT4 chain A against the predicted model Q9L1K2: TM-score 1.00, RMSD 0.37 Å
Elsewhere
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