MolNFT v1 · #115847 · protein
Glge isoform 1 from streptomyces coelicolor E423A mutant soaked in maltoheptaose
5CVS · Alpha-1,4-GLUCAN:MALTOSE-1-phosphate maltosyltransferase 1: “Glge isoform 1 from streptomyces coelicolor E423A mutant soaked in maltoheptaose”. X-ray diffraction, 1 ligand (GLC), 12 pockets (best druggability 0.81). MolNFT v1…
- PDB
- 5CVS
- Type
- protein
- Length
- 1,298 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-1,4-GLUCAN:MALTOSE-1-phosphate maltosyltransferase 1
- EC
- 2.4.99.16
- UniProt
- Q9L1K2
- Ligands
- GLC
- Pockets
- 12 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Alpha-1,4-GLUCAN:MALTOSE-1-phosphate maltosyltransferase 1 (EC 2.4.99.16) | protein | 649 | 34% helix, 25% strand | Q9L1K2 |
Ligands and binding sites
- GLC · alpha-D-glucopyranose · sugar · 24 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1010 | 0.81 | 0.82 | 78 | GLC |
| 2 | 752 | 0.76 | 0.81 | 55 | empty |
| 3 | 334 | 0.73 | 0.85 | 29 | GLC |
| 4 | 842 | 0.70 | 0.76 | 84 | empty |
| 5 | 144 | 0.57 | 0.82 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 2237 Ų buried · 24 hydrogen bonds · protein-protein
Compared structures
- 5CVS · GlgE isoform 1 from Streptomyces coelicolor E423A mutant soaked in maltoheptaose · the same entry in another collection · chain A against A, TM-score 1.00
- Q9L1K2 · AlphaFold monomer V2.0 prediction for alpha-1,4-GLUCAN:MALTOSE-1-phosphate… · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9L1K2
- Elsewhere: RCSB PDB 5CVS · PDBe 5CVS · UniProt Q9L1K2
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