UniProt Q9KL03
Spermidine N(1)-acetyltransferase (Q9KL03)
Spermidine N(1)-acetyltransferase (UniProt Q9KL03), EC 2.3.1.57: 35 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 63 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q9KL03
- Protein
- Spermidine N(1)-acetyltransferase
- EC
- 2.3.1.57
- Experimental structures
- 35
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 63 · 6 records with a druggable one
Structures
36 records of Q9KL03 in the MolNFT archive: 35 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4JJX | Dodecameric structure of spermidine N-acetyltransferase SpeG from Vibrio cholerae O1 biovar eltor | x-ray diffraction | A, B, C | — | — |
| 4JJX | Dodecameric structure of spermidine N-acetyltransferase speg from vibrio cholerae O1 biovar eltor | x-ray diffraction | A, B, C | — | — |
| 4JLY | Dodecameric structure of spermidine N-acetyltransferase from Vibrio cholerae | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4JLY | Dodecameric structure of spermidine N-acetyltransferase from vibrio cholerae | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4MHD | Crystal structure of spermidine N-acetyltransferase from Vibrio cholerae in complex with spermidine | x-ray diffraction | A, B, C | — | — |
| 4MHD | Crystal structure of spermidine N-acetyltransferase from vibrio cholerae in complex with spermidine | x-ray diffraction | A, B, C | — | — |
| 4MI4 | Crystal structure of spermidine N-acetyltransferase from Vibrio cholerae in complex with spermine | x-ray diffraction | A, B, C | — | — |
| 4MI4 | Crystal structure of spermidine N-acetyltransferase from vibrio cholerae in complex with spermine | x-ray diffraction | A, B, C | — | — |
| 4MJ8 | Crystal structure of spermidine N-acetyltransferase from Vibrio cholerae in complex with polyamine | x-ray diffraction | A, B, C | — | — |
| 4MJ8 | Crystal structure of spermidine N-acetyltransferase from vibrio cholerae in complex with polyamine | x-ray diffraction | A, B, C | — | — |
| 4NCZ | Spermidine N-acetyltransferase from Vibrio cholerae in complex with 2-[n-cyclohexylamino]ethane… | x-ray diffraction | A, B, C | — | — |
| 4NCZ | Spermidine N-acetyltransferase from vibrio cholerae in complex with 2- [N-CYCLOHEXYLAMINO]ETHANE… | x-ray diffraction | A, B, C | — | — |
| 4R57 | Crystal structure of spermidine N-acetyltransferase from Vibrio cholerae in complex with acetyl-CoA | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 4R57 | Crystal structure of spermidine N-acetyltransferase from vibrio cholerae in complex with acetyl-CoA | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 4R87 | Crystal structure of spermidine N-acetyltransferase from Vibrio cholerae in complex with CoA and… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 4R87 | Crystal structure of spermidine N-acetyltransferase from vibrio cholerae in complex with CoA and… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 4YGO | Dodecameric structure of spermidine N-acetyltransferase from Vibrio cholerae in intermediate state | x-ray diffraction | A, B, D, C, E, F | — | — |
| 4YGO | Dodecameric structure of spermidine N-acetyltransferase from vibrio cholerae in intermediate state | x-ray diffraction | A, B, D, C, E, F | — | — |
| 5CNP | X-ray crystal structure of spermidine N1-acetyltransferase from vibrio cholerae. | x-ray diffraction | A, B, C, D, E, F | — | — |
| 5UG4 | Structure of spermidine N-acetyltransferase SpeG from Vibrio cholerae | x-ray diffraction | A, B, C | CA | 5 (best 0.85) |
| 5UG4 | Structure of spermidine N-acetyltransferase speg from vibrio cholerae | x-ray diffraction | A, B, C | CA | — |
| 6CX8 | Crystal structure of spermidine/spermine N-acetyltransferase SpeG from Vibrio cholerae in complex… | x-ray diffraction | A, B, C, D, E, F | MN, PO4 | — |
| 6CX8 | Crystal structure of SPERMIDINE/SPERMINE N-acetyltransferase speg from vibrio cholerae in complex… | x-ray diffraction | A, B, C, D, E, F | MN, PO4 | — |
| 6E1X | Crystal structure of product-bound complex of spermidine/spermine N-acetyltransferase SpeG | x-ray diffraction | A, B, C, D, E, F | SPM, SP5, HLG | 20 (best 0.81) |
| 6E1X | Crystal structure of product-bound complex of SPERMIDINE/SPERMINE N- acetyltransferase speg | x-ray diffraction | A, B, C, D, E, F | SPM, SP5, HLG | — |
| 7KWH | Spermidine N-acetyltransferase SpeG K23-Y30 chimera from Vibrio cholerae and hSSAT | x-ray diffraction | A, B, C, D, E, F, J, L, K, G, H, I | PO4 | 20 (best 0.86) |
| 7KWH | Spermidine N-acetyltransferase speg K23-Y30 chimera from vibrio cholerae and hssat | x-ray diffraction | A, B, C, D, E, F, J, L, K, G, H, I | PO4 | — |
| 7KWJ | Spermidine N-acetyltransferase SpeG K23-Q34 chimera from Vibrio cholerae and hSSAT | x-ray diffraction | A, B, C | — | 7 (best 0.71) |
| 7KWJ | Spermidine N-acetyltransferase speg K23-Q34 chimera from vibrio cholerae and hssat | x-ray diffraction | A, B, C | — | — |
| 7KWQ | Spermidine N-acetyltransferase speg R149-K152 chimera from vibrio cholerae and hssat | x-ray diffraction | A, B, C | — | — |
| 7KWX | Spermidine N-acetyltransferase speg N152L mutant from vibrio cholerae | x-ray diffraction | A, B, C | — | — |
| 7KX2 | Spermidine N-acetyltransferase SpeG F149A mutant from Vibrio cholerae | x-ray diffraction | A, B, C | — | 5 (best 0.83) |
| 7KX2 | Spermidine N-acetyltransferase speg F149A mutant from vibrio cholerae | x-ray diffraction | A, B, C | — | — |
| 7KX3 | SpeG Spermidine N-acetyltransferase F149G mutant from Vibrio cholerae | x-ray diffraction | A, B, C | — | 6 (best 0.83) |
| 7KX3 | Speg spermidine N-acetyltransferase F149G mutant from vibrio cholerae | x-ray diffraction | A, B, C | — | — |
| Q9KL03 | AlphaFold monomer V2.0 prediction for spermidine N(1)-acetyltransferase (Q9KL03) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4MJ8 chain B against the predicted model Q9KL03: TM-score 0.99, RMSD 0.59 Å
- 4MJ8 chain B against the predicted model Q9KL03: TM-score 0.99, RMSD 0.59 Å
- 4MI4 chain B against the predicted model Q9KL03: TM-score 0.99, RMSD 0.66 Å
- 4MI4 chain B against the predicted model Q9KL03: TM-score 0.99, RMSD 0.66 Å
- 4MJ8 chain C against the predicted model Q9KL03: TM-score 0.99, RMSD 0.61 Å
- 4MJ8 chain C against the predicted model Q9KL03: TM-score 0.99, RMSD 0.61 Å
- 4R87 chain H against the predicted model Q9KL03: TM-score 0.99, RMSD 0.62 Å
- 4R87 chain H against the predicted model Q9KL03: TM-score 0.99, RMSD 0.62 Å
- 4R57 chain D against the predicted model Q9KL03: TM-score 0.99, RMSD 0.62 Å
- 4R57 chain D against the predicted model Q9KL03: TM-score 0.99, RMSD 0.62 Å
Elsewhere
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