Crystal structure of product-bound complex of SPERMIDINE/SPERMINE N- acetyltransferase speg

Structure

x-ray diffraction · 4 distinct chains.

Ligands and binding sites

• SPM · Spermine · ligand · 6 copies · chains A, B, C, D, E
• SP5 · N-[3-({4-[(3-aminopropyl)amino]butyl}amino) propyl]acetamide · ligand · 3 copies · chains A, E, B, F, D
• HLG · N-{3-[(4-aminobutyl)amino]propyl}acetamide · ligand · chains C
• MRD · (4R)-2-methylpentane-2,4-diol · additive · 5 copies · chains A, C, E, D
• MPD · (4S)-2-methyl-2,4-pentanediol · additive · 3 copies · chains B, C, D
• TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · 2 copies · chains A, D, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6E1X · Crystal structure of product-bound complex of spermidine/spermine N-acetyltransferase SpeG · the same entry in another collection · chain F against F, TM-score 1.00
• Q9KL03 · AlphaFold monomer V2.0 prediction for spermidine N(1)-acetyltransferase (Q9KL03) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9KL03
• Elsewhere: RCSB PDB 6E1X · PDBe 6E1X · UniProt Q9KL03