UniProt Q9K499
Epi-isozizaene synthase (Q9K499)
Epi-isozizaene synthase (UniProt Q9K499), EC 4.2.3.37: 33 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 18 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9K499
- Protein
- Epi-isozizaene synthase
- EC
- 4.2.3.37
- Experimental structures
- 33
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 18 · 5 records with a druggable one
Structures
34 records of Q9K499 in the MolNFT archive: 33 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3KB9 | Epi-isozizaene synthase: Complex with Mg, inorganic pyrophosphate and benzyl triethyl ammonium… | x-ray diffraction | A | — | — |
| 3KB9 | Epi-isozizaene synthase: complex with mg, inorganic pyrophosphate and benzyl triethyl ammonium… | x-ray diffraction | A | — | — |
| 3KBK | Epi-isozizaene synthase complexed with Hg | x-ray diffraction | A | — | — |
| 3KBK | Epi-isozizaene synthase complexed with hg | x-ray diffraction | A | — | — |
| 3LG5 | F198A Epi-isozizaene synthase: Complex with Mg, inorganic pyrophosphate and benzyl triethyl… | x-ray diffraction | A | — | — |
| 3LG5 | F198A epi-isozizaene synthase: complex with mg, inorganic pyrophosphate and benzyl triethyl… | x-ray diffraction | A | — | — |
| 3LGK | D99N Epi-isozizaene synthase | x-ray diffraction | A | — | — |
| 3LGK | D99N epi-isozizaene synthase | x-ray diffraction | A | — | — |
| 4LTV | Crystal structure of epi-isozizaene synthase from Streptomyces coelicolor A3(2) | x-ray diffraction | A | — | — |
| 4LTV | Crystal structure of epi-isozizaene synthase from streptomyces coelicolor A3(2) | x-ray diffraction | A | — | — |
| 4LTZ | F95M Epi-isozizaene synthase: Complex with Mg, inorganic pyrophosphate and benzyl triethyl ammonium… | x-ray diffraction | A | — | — |
| 4LTZ | F95M epi-isozizaene synthase: complex with mg, inorganic pyrophosphate and benzyl triethyl ammonium… | x-ray diffraction | A | — | — |
| 4LUU | V329A Epi-isozizaene synthase: Complex with Mg, inorganic pyrophosphate and benzyl triethyl… | x-ray diffraction | A | — | — |
| 4LUU | V329A epi-isozizaene synthase: complex with mg, inorganic pyrophosphate and benzyl triethyl… | x-ray diffraction | A | — | — |
| 4LXW | L72V Epi-isozizaene synthase: Complex with Mg, inorganic pyrophosphate and benzyl triethyl ammonium… | x-ray diffraction | A | — | — |
| 4LXW | L72V epi-isozizaene synthase: complex with mg, inorganic pyrophosphate and benzyl triethyl ammonium… | x-ray diffraction | A | — | — |
| 4LZ0 | A236G Epi-isozizaene synthase: Complex with Mg, inorganic pyrophosphate and benzyl triethyl… | x-ray diffraction | A | — | — |
| 4LZ0 | A236G epi-isozizaene synthase: complex with mg, inorganic pyrophosphate and benzyl triethyl… | x-ray diffraction | A | — | — |
| 4LZ3 | F95H Epi-isozizaene synthase: Complex with Mg, inorganic pyrophosphate and benzyl triethyl ammonium… | x-ray diffraction | A | — | — |
| 4LZ3 | F95H epi-isozizaene synthase: complex with mg, inorganic pyrophosphate and benzyl triethyl ammonium… | x-ray diffraction | A | — | — |
| 4LZC | W325F Epi-isozizaene synthase: Complex with Mg, inorganic pyrophosphate | x-ray diffraction | A | — | — |
| 4LZC | W325F epi-isozizaene synthase: complex with mg, inorganic pyrophosphate | x-ray diffraction | A | — | — |
| 6AX9 | F95N epi-isozizaene synthase | x-ray diffraction | A | MG, POP, BTM | — |
| 6AXM | F95Y Epi-isozizaene synthase | x-ray diffraction | A | MG, POP, BTM | 3 (best 0.84) |
| 6AXM | F95Y epi-isozizaene synthase | x-ray diffraction | A | MG, POP, BTM | — |
| 6AXN | F95C epi-isozizaene synthase | x-ray diffraction | A | MG, POP, BTM, SO4 | — |
| 6AXO | F96S epi-isozizaene synthase | x-ray diffraction | A | — | — |
| 6AXU | W203Y epi-isozizaene synthase | x-ray diffraction | A | BTM, POP, MG | — |
| 6OFV | F95Q Epi-isozizaene synthase | x-ray diffraction | A | POP, MG, BTM, SO4 | 4 (best 0.81) |
| 6OFV | F95Q epi-isozizaene synthase | x-ray diffraction | A | POP, MG, BTM, SO4 | — |
| 8SU0 | Unliganded F96H epi-Isozizaene Synthase | x-ray diffraction | A | SO4 | 2 (best 0.68) |
| 8SU1 | F96H epi-Isozizaene Synthase: complex with 3 Mg2+ and pamidronate | x-ray diffraction | A | SO4, MG, 210 | 4 (best 0.83) |
| 8SU2 | F96H epi-Isozizaene Synthase: complex with 3 Mg2+ and risedronate | x-ray diffraction | A | SO4, RIS, MG | 5 (best 0.80) |
| Q9K499 | AlphaFold monomer V2.0 prediction for epi-isozizaene synthase (Q9K499) | predicted | A | — | — |
Ligands
Experiment against prediction
- 3LG5 chain A against the predicted model Q9K499: TM-score 1.00, RMSD 0.15 Å
- 3LG5 chain A against the predicted model Q9K499: TM-score 1.00, RMSD 0.15 Å
- 4LZ0 chain A against the predicted model Q9K499: TM-score 1.00, RMSD 0.16 Å
- 4LZ0 chain A against the predicted model Q9K499: TM-score 1.00, RMSD 0.16 Å
- 3KB9 chain A against the predicted model Q9K499: TM-score 1.00, RMSD 0.17 Å
- 3KB9 chain A against the predicted model Q9K499: TM-score 1.00, RMSD 0.17 Å
- 4LXW chain A against the predicted model Q9K499: TM-score 1.00, RMSD 0.17 Å
- 4LXW chain A against the predicted model Q9K499: TM-score 1.00, RMSD 0.17 Å
- 4LUU chain A against the predicted model Q9K499: TM-score 1.00, RMSD 0.18 Å
- 4LUU chain A against the predicted model Q9K499: TM-score 1.00, RMSD 0.18 Å
Elsewhere
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