UniProt Q9BQA1
Methylosome protein 50 (Q9BQA1)
Methylosome protein 50 (UniProt Q9BQA1): 80 experimental structures on GenesisL1, 94 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q9BQA1
- Protein
- Methylosome protein 50
- Experimental structures
- 80
- Predicted models
- 0
- Pockets
- 94 · 29 records with a druggable one
Structures
80 records of Q9BQA1 in the MolNFT archive: 80 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4GQB | Crystal Structure of the human PRMT5:MEP50 Complex | x-ray diffraction | B | — | — |
| 4GQB | Crystal structure of the human PRMT5:MEP50 complex | x-ray diffraction | B | — | — |
| 4X60 | Crystal structure of PRMT5:MEP50 with EPZ015666 and sinefungin | x-ray diffraction | B | — | — |
| 4X60 | Crystal structure of PRMT5:MEP50 with EPZ015666 and sinefungin | x-ray diffraction | B | — | — |
| 4X61 | Crystal structure of PRMT5:MEP50 with EPZ015666 and SAM | x-ray diffraction | B | — | — |
| 4X61 | Crystal structure of PRMT5:MEP50 with EPZ015666 and SAM | x-ray diffraction | B | — | — |
| 4X63 | Crystal structure of PRMT5:MEP50 with EPZ015666 and SAH | x-ray diffraction | B | — | — |
| 4X63 | Crystal structure of PRMT5:MEP50 with EPZ015666 and sah | x-ray diffraction | B | — | — |
| 5C9Z | Crystal structure of PRMT5:MEP50 with EPZ015866 and sinefungin | x-ray diffraction | B | — | — |
| 5C9Z | Crystal structure of PRMT5:MEP50 with EPZ015866 and sinefungin | x-ray diffraction | B | — | — |
| 5EMJ | Crystal structure of PRMT5:MEP50 with Compound 8 and sinefungin | x-ray diffraction | B | — | — |
| 5EMJ | Crystal structure of PRMT5:MEP50 with compound 8 and sinefungin | x-ray diffraction | B | — | — |
| 5EMK | Crystal structure of PRMT5:MEP50 with Compound 9 and sinefungin | x-ray diffraction | B | — | — |
| 5EMK | Crystal structure of PRMT5:MEP50 with compound 9 and sinefungin | x-ray diffraction | B | — | — |
| 5EML | Crystal structure of PRMT5:MEP50 with Compound 10 and SAM | x-ray diffraction | B | — | — |
| 5EML | Crystal structure of PRMT5:MEP50 with compound 10 and SAM | x-ray diffraction | B | — | — |
| 5EMM | Crystal structure of PRMT5:MEP50 with Compound 15 and sinefungin | x-ray diffraction | B | — | — |
| 5EMM | Crystal structure of PRMT5:MEP50 with compound 15 and sinefungin | x-ray diffraction | B | — | — |
| 5FA5 | Crystal Structure of PRMT5:MEP50 in complex with MTA and H4 peptide | x-ray diffraction | B | — | 1 (best 0.88) |
| 5FA5 | Crystal structure of PRMT5:MEP50 in complex with mta and H4 peptide | x-ray diffraction | B | — | — |
| 6CKC | Structure of PRMT5:MEP50 in complex with LLY-283, a potent and selective inhibitor of PRMT5, with… | x-ray diffraction | B | — | 2 (best 0.84) |
| 6CKC | Structure of PRMT5:MEP50 in complex with lly-283, a potent and selective inhibitor of PRMT5, with… | x-ray diffraction | B | — | — |
| 6K1S | Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase (PRMT5) Inhibitors | x-ray diffraction | B | — | — |
| 6K1S | Discovery of potent and selective covalent protein arginine methyltransferase (PRMT5) inhibitors | x-ray diffraction | B | — | — |
| 6RLL | CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX with JNJ44064146 | x-ray diffraction | B | — | 1 (best 0.88) |
| 6RLL | Crystal structure of the human PRMT5:MEP50 complex with JNJ44064146 | x-ray diffraction | B | — | — |
| 6RLQ | Crystal structure of the human PRMT5:MEP50 complex with JNJ45031882 | x-ray diffraction | B | — | — |
| 6UGH | Cryo-EM structure of the apo form of human PRMT5:MEP50 complex at a resolution of 3.4 ångström | electron microscopy | B | — | — |
| 6UXX | PRMT5:MEP50 complexed with allosteric inhibitor compound 1A | x-ray diffraction | B | — | — |
| 6UXY | PRMT5:MEP50 complexed with allosteric inhibitor compound 8 | x-ray diffraction | B | — | — |
| 6V0N | PRMT5 bound to PBM peptide from Riok1 | x-ray diffraction | B | — | 2 (best 0.85) |
| 6V0N | PRMT5 bound to pbm peptide from RIOK1 | x-ray diffraction | B | — | — |
| 6V0O | PRMT5 bound to the PBM peptide from pICln | x-ray diffraction | B | — | 3 (best 0.85) |
| 6V0O | PRMT5 bound to the pbm peptide from picln | x-ray diffraction | B | — | — |
| 6V0P | PRMT5 complex bound to covalent PBM inhibitor BRD6711 | x-ray diffraction | B | — | 3 (best 0.88) |
| 6V0P | PRMT5 complex bound to covalent pbm inhibitor BRD6711 | x-ray diffraction | B | — | — |
| 7BO7 | CRYSTAL STRUCTURE OF THE HUMAN PRMT5:MEP50 COMPLEX with JNJB44355437 | x-ray diffraction | BBB | — | 3 (best 0.85) |
| 7KIB | PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 4 | x-ray diffraction | B | — | 3 (best 0.85) |
| 7KIB | PRMT5:MEP50 complexed with 5,5-bicyclic inhibitor compound 4 | x-ray diffraction | B | — | — |
| 7KIC | PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 34 | x-ray diffraction | B | — | — |
| 7KIC | PRMT5:MEP50 complexed with 5,5-bicyclic inhibitor compound 34 | x-ray diffraction | B | — | — |
| 7KID | PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 72 | x-ray diffraction | B | — | 3 (best 0.87) |
| 7KID | PRMT5:MEP50 complexed with 5,5-bicyclic inhibitor compound 72 | x-ray diffraction | B | — | — |
| 7L1G | PRMT5-MEP50 Complexed with SAM | x-ray diffraction | B | — | 4 (best 0.85) |
| 7L1G | PRMT5-MEP50 complexed with SAM | x-ray diffraction | B | — | — |
| 7M05 | CryoEM structure of PRMT5 bound to covalent PBM-site inhibitor BRD-6988 | electron microscopy | B, D, F, H | — | 8 (best 0.85) |
| 7M05 | Cryoem structure of PRMT5 bound to covalent pbm-site inhibitor brd- 6988 | electron microscopy | B, D, F, H | — | — |
| 7MX7 | PRMT5:MEP50 complexed with inhibitor PF-06939999 | x-ray diffraction | B | — | 3 (best 0.83) |
| 7MX7 | PRMT5:MEP50 complexed with inhibitor pf-06939999 | x-ray diffraction | B | — | — |
| 7MXA | PRMT5:MEP50 complexed with inhibitor pf-06855800 | x-ray diffraction | B | — | — |
| 7MXC | PRMT5:MEP50 complexed with adenosine | x-ray diffraction | B | — | — |
| 7MXG | PRMT5(M420T MUTANT):MEP50 complexed with inhibitor pf-06855800 | x-ray diffraction | B, D | — | — |
| 7MXN | PRMT5(M420T MUTANT):MEP50 complexed with inhibitor pf-06939999 | x-ray diffraction | B | — | — |
| 7S0U | PRMT5/MEP50 crystal structure with MTA and phthalazi fragment bound | x-ray diffraction | B | — | 3 (best 0.82) |
| 7S0U | PRMT5/MEP50 crystal structure with mta and phthalazinone fragment bound | x-ray diffraction | B | — | — |
| 7S1P | PRMT5/MEP50 crystal structure with sinefungin bound | x-ray diffraction | B | — | — |
| 7S1Q | PRMT5/MEP50 crystal structure with MTA and a phthalazi inhibitor bound (Compound 9) | x-ray diffraction | B | — | 2 (best 0.85) |
| 7S1Q | PRMT5/MEP50 crystal structure with mta and a phthalazinone inhibitor bound (compound 9) | x-ray diffraction | B | — | — |
| 7S1R | PRMT5/MEP50 crystal structure with mta and a phthalazinone inhibitor bound (compound (M)-31) | x-ray diffraction | B | — | — |
| 7S1S | PRMT5/MEP50 crystal structure with mta and mrtx-1719 bound | x-ray diffraction | B | — | — |
20 records more on the page itself.
Elsewhere
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