PRMT5:MEP50 complexed with 5,5-bicyclic inhibitor compound 34

Structure

x-ray diffraction · 2 distinct chains.

Ligands and binding sites

• WFS · (2r,3r,3as,6s,6ar)-6-[(2-amino-3-bromoquinolin-7-yl) oxy]-2-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl) hexahydro-3AH-cyclopenta[b]furan-3,3A-diol · ligand · chains A
• EDO · 1,2-ethanediol · additive · 6 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7KIC · PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 34 · the same entry in another collection · chain A against A, TM-score 1.00
• Q9BQA1 · AlphaFold monomer V2.0 prediction for methylosome protein 50 (Q9BQA1) · a predicted model of the same protein · chain B against A, TM-score 0.99
• O14744 · AlphaFold monomer V2.0 prediction for protein arginine N-methyltransferase 5 (O14744) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O14744
• Every structure of UniProt Q9BQA1
• Elsewhere: RCSB PDB 7KIC · PDBe 7KIC · UniProt O14744 · UniProt Q9BQA1