PRMT5/MEP50 crystal structure with mta and phthalazinone fragment bound

Structure

x-ray diffraction · 2 distinct chains.

Ligands and binding sites

• 81X · 4-(aminomethyl)phthalazin-1(2H)-one · ligand · chains A
• MTA · 5'-deoxy-5'-methylthioadenosine · ligand · chains A
• NA · Sodium ion · metal · chains A
• CL · Chloride ion · ion · chains A
• EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7S0U · PRMT5/MEP50 crystal structure with MTA and phthalazi fragment bound · the same entry in another collection · chain A against A, TM-score 1.00
• Q9BQA1 · AlphaFold monomer V2.0 prediction for methylosome protein 50 (Q9BQA1) · a predicted model of the same protein · chain B against A, TM-score 1.00
• O14744 · AlphaFold monomer V2.0 prediction for protein arginine N-methyltransferase 5 (O14744) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O14744
• Every structure of UniProt Q9BQA1
• Elsewhere: RCSB PDB 7S0U · PDBe 7S0U · UniProt O14744 · UniProt Q9BQA1