MolNFT v1 · #166784 · protein
PRMT5 complex bound to covalent pbm inhibitor BRD6711
6V0P: “PRMT5 complex bound to covalent pbm inhibitor BRD6711”. X-ray diffraction, 2 ligands (QN4, CL). MolNFT v1 #166784 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6V0P
- Type
- protein
- Length
- 917 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- O14744, Q9BQA1
- Ligands
- QN4, CL
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 622 | — | O14744 |
| B | — | protein | 295 | — | Q9BQA1 |
Ligands and binding sites
- QN4 · 2-(5-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-sulfamoylphenyl)acetamide · ligand · chains A
- CL · Chloride ion · ion · 2 copies · chains A
- GOL · Glycerol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6V0P · PRMT5 complex bound to covalent PBM inhibitor BRD6711 · the same entry in another collection · chain B against B, TM-score 1.00
- Q9BQA1 · AlphaFold monomer V2.0 prediction for methylosome protein 50 (Q9BQA1) · a predicted model of the same protein · chain B against A, TM-score 1.00
- O14744 · AlphaFold monomer V2.0 prediction for protein arginine N-methyltransferase 5 (O14744) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14744
- Every structure of UniProt Q9BQA1
- Elsewhere: RCSB PDB 6V0P · PDBe 6V0P · UniProt O14744 · UniProt Q9BQA1
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