MolNFT v1 · #182582 · protein
PRMT5:MEP50 complexed with inhibitor pf-06855800
7MXA: “PRMT5:MEP50 complexed with inhibitor pf-06855800”. X-ray diffraction, 1 ligand (ZR4). MolNFT v1 #182582 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7MXA
- Type
- protein
- Length
- 928 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- O14744, Q9BQA1
- Ligands
- ZR4
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 621 | — | O14744 |
| B | — | protein | 307 | — | Q9BQA1 |
Ligands and binding sites
- ZR4 · 7-[(5R)-5-C-(4-chloro-3-fluorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7MXA · PRMT5:MEP50 complexed with inhibitor PF-06855800 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9BQA1 · AlphaFold monomer V2.0 prediction for methylosome protein 50 (Q9BQA1) · a predicted model of the same protein · chain B against A, TM-score 0.99
- O14744 · AlphaFold monomer V2.0 prediction for protein arginine N-methyltransferase 5 (O14744) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14744
- Every structure of UniProt Q9BQA1
- Elsewhere: RCSB PDB 7MXA · PDBe 7MXA · UniProt O14744 · UniProt Q9BQA1
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