Ligand · ZR4
ZR4 · 7-[(5R)-5-C-(4-chloro-3-fluorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
ZR4, 7-[(5R)-5-C-(4-chloro-3-fluorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine (C17 H16 Cl F N4 O4, 394.8 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its…
- Component
- ZR4
- Formula
- C17 H16 Cl F N4 O4
- Class
- ligand
- Structures
- 4
- PDB entries
- 2
Binding sites
ZR4 in 4 structures; the first of them:
- 7MXA · PRMT5:MEP50 complexed with inhibitor PF-06855800 · ZR4 A701 · binds PRO314, LEU315, LEU319, TYR324, PHE327, GLU328, TYR334, GLY365 and 13 more
- 7MXG · PRMT5(M420T mutant):MEP50 complexed with inhibitor PF-06855800 · ZR4 A701 · binds PRO314, LEU315, LEU319, TYR324, PHE327, GLU328, TYR334, GLY365 and 12 more
- 7MXA · PRMT5:MEP50 complexed with inhibitor pf-06855800 · ZR4 A701 · binds PRO314, LEU315, LEU319, TYR324, PHE327, TYR334, GLY365, GLY367 and 10 more
- 7MXG · PRMT5(M420T MUTANT):MEP50 complexed with inhibitor pf-06855800 · ZR4 A701 · binds PRO314, LEU315, LEU319, TYR324, PHE327, TYR334, GLY365, GLY367 and 10 more
Residues it binds most
GLU 6, LEU 6, GLY 6, TYR 6, LYS 6, ASN 6, ASP 6, CYS 6, PHE 6, PRO 6 (residue and the binding sites it lines).
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