UniProt Q96QZ7
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1,Annexin A2 (Q96QZ7)
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1,Annexin A2 (UniProt Q96QZ7): 32 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 46 pockets. Binding sites, druggability and…
- UniProt
- Q96QZ7
- Protein
- Membrane-associated guanylate kinase, WW and PDZ domain-containing protein…
- Experimental structures
- 32
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 46 · 5 records with a druggable one
Structures
33 records of Q96QZ7 in the MolNFT archive: 32 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1WBP | SRPK1 bound to 9mer docking motif peptide | x-ray diffraction | B | — | — |
| 1WBP | SRPK1 bound to 9MER docking motif peptide | x-ray diffraction | B | — | — |
| 2KPK | MAGI-1 PDZ1 | solution nmr | A | — | — |
| 2KPK | MAGI-1 PDZ1 | solution nmr | A | — | — |
| 2KPL | Magi-1 PDZ1 / E6CT | solution nmr | A | — | — |
| 2KPL | Magi-1 PDZ1 / E6CT | solution nmr | A | — | — |
| 2Q9V | Crystal structure of the C890S mutant of the 4th PDZ domain of human membrane associated guanylate… | x-ray diffraction | A | — | — |
| 2Q9V | Crystal structure of the C890S mutant of the 4TH PDZ domain of human membrane associated guanylate… | x-ray diffraction | A | — | — |
| 2R4H | Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate… | x-ray diffraction | A, B, C | — | — |
| 2R4H | Crystal structure of a C1190S mutant of the 6TH PDZ domain of human membrane associated guanylate… | x-ray diffraction | A, B, C | — | — |
| 2YSD | Solution structure of the first WW domain from the human membrane-associated guanylate kinase, WW… | solution nmr | A | — | — |
| 2YSD | Solution structure of the first ww domain from the human membrane- associated guanylate kinase, ww… | solution nmr | A | — | — |
| 2YSE | Solution structure of the second WW domain from the human membrane-associated guanylate kinase, WW… | solution nmr | A | — | — |
| 2YSE | Solution structure of the second ww domain from the human membrane- associated guanylate kinase, ww… | solution nmr | A | — | — |
| 2ZAJ | Solution structure of the short-isoform of the second WW domain from the human membrane-associated… | solution nmr | A | — | — |
| 2ZAJ | Solution structure of the short-isoform of the second ww domain from the human membrane-associated… | solution nmr | A | — | — |
| 3BPU | Crystal structure of the 3rd PDZ domain of human membrane associated guanylate kinase, C677S and… | x-ray diffraction | A | — | — |
| 3BPU | Crystal structure of the 3RD PDZ domain of human membrane associated guanylate kinase, C677S and… | x-ray diffraction | A | — | — |
| 5N7D | MAGI-1 complexed with a RSK1 peptide | x-ray diffraction | A, B | CA | — |
| 5N7D | Magi-1 complexed with a RSK1 peptide | x-ray diffraction | A, B | CA | — |
| 5N7F | MAGI-1 complexed with a pRSK1 peptide | x-ray diffraction | A, B | CA | — |
| 5N7F | Magi-1 complexed with a PRSK1 peptide | x-ray diffraction | A, B | CA | — |
| 5N7G | MAGI-1 complexed with a synthetic pRSK1 peptide | x-ray diffraction | A, B | CA | 12 (best 0.75) |
| 5N7G | Magi-1 complexed with a synthetic PRSK1 peptide | x-ray diffraction | A, B | CA | — |
| 6TWU | MAGI1_2 complexed with a phosphomimetic 16E6 peptide | x-ray diffraction | A, B | CA | 9 (best 0.76) |
| 6TWU | MAGI1_2 complexed with a phosphomimetic 16E6 peptide | x-ray diffraction | A, B | CA | — |
| 6TWX | MAGI1_2 complexed with a phosphorylated 16E6 peptide | x-ray diffraction | A, B | CA | 7 (best 0.76) |
| 6TWX | MAGI1_2 complexed with a phosphorylated 16E6 peptide | x-ray diffraction | A, B | CA | — |
| 6TWY | MAGI1_2 complexed with a phosphomimetic RSK1 peptide | x-ray diffraction | A, B | CA | 10 (best 0.76) |
| 6TWY | MAGI1_2 complexed with a phosphomimetic RSK1 peptide | x-ray diffraction | A, B | CA | — |
| 7P71 | The PDZ domain of MAGI1_2 complexed with the PDZ-binding motif of HPV35-E6 | x-ray diffraction | A, B | CA | 8 (best 0.76) |
| 7P71 | The PDZ domain of MAGI1_2 complexed with the PDZ-binding motif of HPV35-E6 | x-ray diffraction | A, B | CA | — |
| Q96QZ7 | AlphaFold monomer V2.0 prediction for membrane-associated guanylate kinase, ww and PDZ… | predicted | A | — | — |
Ligands
- CA · Calcium ion · in 14 records
Experiment against prediction
- 5N7G chain B against the predicted model P07355: TM-score 0.99, RMSD 0.72 Å
- 5N7G chain B against the predicted model P07355: TM-score 0.99, RMSD 0.72 Å
- 2Q9V chain A against the predicted model Q96QZ7: TM-score 0.95, RMSD 1.12 Å
- 2Q9V chain A against the predicted model Q96QZ7: TM-score 0.95, RMSD 1.12 Å
- 6TWY chain B against the predicted model P07355: TM-score 0.77, RMSD 1.51 Å
- 6TWY chain B against the predicted model P07355: TM-score 0.77, RMSD 1.51 Å
- 7P71 chain A against the predicted model P07355: TM-score 0.76, RMSD 1.56 Å
- 7P71 chain A against the predicted model P07355: TM-score 0.76, RMSD 1.56 Å
- 6TWU chain B against the predicted model P07355: TM-score 0.77, RMSD 1.36 Å
- 6TWU chain B against the predicted model P07355: TM-score 0.77, RMSD 1.36 Å
Elsewhere
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