MolNFT v1 · #25990 · protein
SRPK1 bound to 9MER docking motif peptide
1WBP · SERINE/THREONINE-protein kinase SPRK1: “SRPK1 bound to 9MER docking motif peptide”. X-ray diffraction, 1 ligand (ADP), 4 pockets (best druggability 0.69). MolNFT v1 #25990 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 1WBP
- Type
- protein
- Length
- 357 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein kinase SPRK1; Membrane-associated guanylate kinase, ww and PDZ…
- EC
- 2.7.1.37
- UniProt
- Q12890, Q96QZ7
- Ligands
- ADP
- Pockets
- 4 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein kinase SPRK1 (EC 2.7.1.37) | protein | 350 | 41% helix, 17% strand | Q12890 |
| B | Membrane-associated guanylate kinase, ww and PDZ domain- containing protein 1 | protein | 7 | 0% helix, 0% strand | Q96QZ7 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 566 | 0.69 | 0.78 | 57 | ADP |
| 2 | 100 | 0.43 | 0.78 | 28 | empty |
| 3 | 92 | 0.37 | 0.75 | 14 | empty |
| 4 | 61 | 0.28 | 0.73 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 538 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12890
- Every structure of UniProt Q96QZ7
- Elsewhere: RCSB PDB 1WBP · PDBe 1WBP · UniProt Q12890 · UniProt Q96QZ7
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