MolNFT v1 · #42659 · protein

Magi-1 PDZ1 / E6CT

2KPL · Membrane-associated guanylate kinase, ww and PDZ domain…: “Magi-1 PDZ1 / E6CT”. Solution nmr, 1 pocket (best druggability 0.68). MolNFT v1 #42659 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2KPL
Type: protein
Length: 140 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Membrane-associated guanylate kinase, ww and PDZ domain- containing protein 1; Protein E6
UniProt: Q96QZ7, P03126
Pockets: 1 · best druggability 0.68

Structure

solution nmr · 2 distinct chains · 11% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Membrane-associated guanylate kinase, ww and PDZ domain- containing protein 1	protein	129	12% helix, 31% strand	Q96QZ7
B	Protein E6	protein	11	0% helix, 36% strand	P03126

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	143	0.68	0.89	22	empty

Interfaces

1 interface between chains.

A–B · 861 Å² buried · 30 hydrogen bonds · protein-protein

Compared structures

2KPL · Magi-1 PDZ1 / E6CT · the same entry in another collection · chain A against A, TM-score 1.00
Q96QZ7 · AlphaFold monomer V2.0 prediction for membrane-associated guanylate kinase, ww and PDZ… · a predicted model of the same protein · chain A against A, TM-score 0.73

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96QZ7
Every structure of UniProt P03126
Elsewhere: RCSB PDB 2KPL · PDBe 2KPL · UniProt Q96QZ7 · UniProt P03126

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